The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs
Само за регистроване кориснике
2016
Аутори
Okić Đorđević, IvanaKukolj, Tamara
Krstić, Jelena
Trivanović, Drenka
Obradović, Hristina
Santibanez, Juan F.
Mojsilović, Slavko
Ilić, Vesna
Bugarski, Diana
Jauković, Aleksandra
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Periodontal disease (PD), a degenerative bacterially induced disease of periodontium, can lead to bone resorption and teeth loss. Development of PD includes a strong inflammatory reaction, which involves multiple immune cells and their secreting factors including interleukin-17 (IL-17), which is not only an important modulator of immune and hematopoietic responses but also affects bone metabolism. In the present study we aimed to determine whether IL-17 affects the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) by investigating its ability to modulate osteogenic differentiation of these cells in vitro along with associated signaling pathways. Our results revealed that IL-17 inhibited both the proliferation and migration of PDLSCs and decreased their osteogenic differentiation by activating ERK1,2 and JNK mitogen-activated protein kinases. Obtained data suggested that IL-17 might contribute to alveolar bone loss in PD.
Кључне речи:
Interleukin-17 / Periodontal ligament mesenchymal stem cells / Osteogenic differentiation / Immunomodulatory capacityИзвор:
International Journal of Biochemistry & Cell Biology, 2016, 71, 92-101Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
DOI: 10.1016/j.biocel.2015.12.007
ISSN: 1357-2725
PubMed: 26718973
WoS: 000369679800010
Scopus: 2-s2.0-84952802093
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Okić Đorđević, Ivana AU - Kukolj, Tamara AU - Krstić, Jelena AU - Trivanović, Drenka AU - Obradović, Hristina AU - Santibanez, Juan F. AU - Mojsilović, Slavko AU - Ilić, Vesna AU - Bugarski, Diana AU - Jauković, Aleksandra PY - 2016 UR - http://rimi.imi.bg.ac.rs/handle/123456789/731 AB - Periodontal disease (PD), a degenerative bacterially induced disease of periodontium, can lead to bone resorption and teeth loss. Development of PD includes a strong inflammatory reaction, which involves multiple immune cells and their secreting factors including interleukin-17 (IL-17), which is not only an important modulator of immune and hematopoietic responses but also affects bone metabolism. In the present study we aimed to determine whether IL-17 affects the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) by investigating its ability to modulate osteogenic differentiation of these cells in vitro along with associated signaling pathways. Our results revealed that IL-17 inhibited both the proliferation and migration of PDLSCs and decreased their osteogenic differentiation by activating ERK1,2 and JNK mitogen-activated protein kinases. Obtained data suggested that IL-17 might contribute to alveolar bone loss in PD. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - International Journal of Biochemistry & Cell Biology T1 - The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs EP - 101 SP - 92 VL - 71 DO - 10.1016/j.biocel.2015.12.007 ER -
@article{ author = "Okić Đorđević, Ivana and Kukolj, Tamara and Krstić, Jelena and Trivanović, Drenka and Obradović, Hristina and Santibanez, Juan F. and Mojsilović, Slavko and Ilić, Vesna and Bugarski, Diana and Jauković, Aleksandra", year = "2016", abstract = "Periodontal disease (PD), a degenerative bacterially induced disease of periodontium, can lead to bone resorption and teeth loss. Development of PD includes a strong inflammatory reaction, which involves multiple immune cells and their secreting factors including interleukin-17 (IL-17), which is not only an important modulator of immune and hematopoietic responses but also affects bone metabolism. In the present study we aimed to determine whether IL-17 affects the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) by investigating its ability to modulate osteogenic differentiation of these cells in vitro along with associated signaling pathways. Our results revealed that IL-17 inhibited both the proliferation and migration of PDLSCs and decreased their osteogenic differentiation by activating ERK1,2 and JNK mitogen-activated protein kinases. Obtained data suggested that IL-17 might contribute to alveolar bone loss in PD.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "International Journal of Biochemistry & Cell Biology", title = "The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs", pages = "101-92", volume = "71", doi = "10.1016/j.biocel.2015.12.007" }
Okić Đorđević, I., Kukolj, T., Krstić, J., Trivanović, D., Obradović, H., Santibanez, J. F., Mojsilović, S., Ilić, V., Bugarski, D.,& Jauković, A.. (2016). The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs. in International Journal of Biochemistry & Cell Biology Pergamon-Elsevier Science Ltd, Oxford., 71, 92-101. https://doi.org/10.1016/j.biocel.2015.12.007
Okić Đorđević I, Kukolj T, Krstić J, Trivanović D, Obradović H, Santibanez JF, Mojsilović S, Ilić V, Bugarski D, Jauković A. The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs. in International Journal of Biochemistry & Cell Biology. 2016;71:92-101. doi:10.1016/j.biocel.2015.12.007 .
Okić Đorđević, Ivana, Kukolj, Tamara, Krstić, Jelena, Trivanović, Drenka, Obradović, Hristina, Santibanez, Juan F., Mojsilović, Slavko, Ilić, Vesna, Bugarski, Diana, Jauković, Aleksandra, "The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs" in International Journal of Biochemistry & Cell Biology, 71 (2016):92-101, https://doi.org/10.1016/j.biocel.2015.12.007 . .