Periodontal disease (PD), a degenerative bacterially induced disease of periodontium, can lead to bone resorption and teeth loss. Development of PD includes a strong inflammatory reaction, which involves multiple immune cells and their secreting factors including interleukin-17 (IL-17), which is not only an important modulator of immune and hematopoietic responses but also affects bone metabolism. In the present study we aimed to determine whether IL-17 affects the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) by investigating its ability to modulate osteogenic differentiation of these cells in vitro along with associated signaling pathways. Our results revealed that IL-17 inhibited both the proliferation and migration of PDLSCs and decreased their osteogenic differentiation by activating ERK1,2 and JNK mitogen-activated protein kinases. Obtained data suggested that IL-17 might contribute to alveolar bone loss in PD.
TY - JOUR
AU - Okić-Đorđević, Ivana
AU - Kukolj, Tamara
AU - Krstić, Jelena
AU - Trivanović, Drenka
AU - Obradović, Hristina
AU - Santibanez, Juan
AU - Mojsilović, Slavko
AU - Ilić, Vesna
AU - Bugarski, Diana
AU - Jauković, Aleksandra
PY - 2016
UR - http://rimi.imi.bg.ac.rs/handle/123456789/731
AB - Periodontal disease (PD), a degenerative bacterially induced disease of periodontium, can lead to bone resorption and teeth loss. Development of PD includes a strong inflammatory reaction, which involves multiple immune cells and their secreting factors including interleukin-17 (IL-17), which is not only an important modulator of immune and hematopoietic responses but also affects bone metabolism. In the present study we aimed to determine whether IL-17 affects the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) by investigating its ability to modulate osteogenic differentiation of these cells in vitro along with associated signaling pathways. Our results revealed that IL-17 inhibited both the proliferation and migration of PDLSCs and decreased their osteogenic differentiation by activating ERK1,2 and JNK mitogen-activated protein kinases. Obtained data suggested that IL-17 might contribute to alveolar bone loss in PD.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - International Journal of Biochemistry & Cell Biology
T1 - The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs
EP - 101
SP - 92
VL - 71
DO - 10.1016/j.biocel.2015.12.007
ER -
@article{
author = "Okić-Đorđević, Ivana and Kukolj, Tamara and Krstić, Jelena and Trivanović, Drenka and Obradović, Hristina and Santibanez, Juan and Mojsilović, Slavko and Ilić, Vesna and Bugarski, Diana and Jauković, Aleksandra",
year = "2016",
abstract = "Periodontal disease (PD), a degenerative bacterially induced disease of periodontium, can lead to bone resorption and teeth loss. Development of PD includes a strong inflammatory reaction, which involves multiple immune cells and their secreting factors including interleukin-17 (IL-17), which is not only an important modulator of immune and hematopoietic responses but also affects bone metabolism. In the present study we aimed to determine whether IL-17 affects the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) by investigating its ability to modulate osteogenic differentiation of these cells in vitro along with associated signaling pathways. Our results revealed that IL-17 inhibited both the proliferation and migration of PDLSCs and decreased their osteogenic differentiation by activating ERK1,2 and JNK mitogen-activated protein kinases. Obtained data suggested that IL-17 might contribute to alveolar bone loss in PD.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "International Journal of Biochemistry & Cell Biology",
title = "The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs",
pages = "101-92",
volume = "71",
doi = "10.1016/j.biocel.2015.12.007"
}
Okić-Đorđević, I., Kukolj, T., Krstić, J., Trivanović, D., Obradović, H., Santibanez, J., Mojsilović, S., Ilić, V., Bugarski, D.,& Jauković, A.. (2016). The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs. in International Journal of Biochemistry & Cell Biology
Pergamon-Elsevier Science Ltd, Oxford., 71, 92-101.
https://doi.org/10.1016/j.biocel.2015.12.007
conv_3694
Okić-Đorđević I, Kukolj T, Krstić J, Trivanović D, Obradović H, Santibanez J, Mojsilović S, Ilić V, Bugarski D, Jauković A. The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs. in International Journal of Biochemistry & Cell Biology. 2016;71:92-101.
doi:10.1016/j.biocel.2015.12.007
conv_3694 .
Okić-Đorđević, Ivana, Kukolj, Tamara, Krstić, Jelena, Trivanović, Drenka, Obradović, Hristina, Santibanez, Juan, Mojsilović, Slavko, Ilić, Vesna, Bugarski, Diana, Jauković, Aleksandra, "The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs" in International Journal of Biochemistry & Cell Biology, 71 (2016):92-101,
https://doi.org/10.1016/j.biocel.2015.12.007 .,
conv_3694 .
