Stromal vascular fraction of the adipose tissue is recognized as reservoir of the cell populations with stem and progenitor properties. Besides the roles of adipose tissue stem and progenitor cells (ASPCs) in adipose tissue development and homeostasis, particularly interest is given to their functions in adipose tissue expansion and obesity. Obesity-driven low-grade chronic inflammation, reduction of oxygen level in adipose tissue and engagement of bone marrow, support recruitment of various progenitor cells in adipose tissue. Activation of bone marrow-adipose tissue axis regulates hematopoiesis and infiltration of immune cells in adipose tissue. Obesity-associated factors can provoke alteration of ASPC multipotent differentiation and immunosuppressive potential. Determination of underpinning mechanisms in altered (obese) ASPC phenotype may contribute to development of novel approaches for treatment of metabolic disorders and advancement the safety and efficiency of adipose tissue graf...ting.
TY - JOUR
AU - Trivanović, Drenka
AU - Krstić, Jelena
AU - Santibanez, Juan
AU - Jauković, Aleksandra
AU - Bugarski, Diana
PY - 2016
UR - http://rimi.imi.bg.ac.rs/handle/123456789/707
AB - Stromal vascular fraction of the adipose tissue is recognized as reservoir of the cell populations with stem and progenitor properties. Besides the roles of adipose tissue stem and progenitor cells (ASPCs) in adipose tissue development and homeostasis, particularly interest is given to their functions in adipose tissue expansion and obesity. Obesity-driven low-grade chronic inflammation, reduction of oxygen level in adipose tissue and engagement of bone marrow, support recruitment of various progenitor cells in adipose tissue. Activation of bone marrow-adipose tissue axis regulates hematopoiesis and infiltration of immune cells in adipose tissue. Obesity-associated factors can provoke alteration of ASPC multipotent differentiation and immunosuppressive potential. Determination of underpinning mechanisms in altered (obese) ASPC phenotype may contribute to development of novel approaches for treatment of metabolic disorders and advancement the safety and efficiency of adipose tissue grafting.
T2 - Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry
T1 - Obesity: An emerging importance of progenitors
EP - 160
IS - 3
SP - 148
VL - 16
DO - 10.2174/1871522217666170105092757
ER -
@article{
author = "Trivanović, Drenka and Krstić, Jelena and Santibanez, Juan and Jauković, Aleksandra and Bugarski, Diana",
year = "2016",
abstract = "Stromal vascular fraction of the adipose tissue is recognized as reservoir of the cell populations with stem and progenitor properties. Besides the roles of adipose tissue stem and progenitor cells (ASPCs) in adipose tissue development and homeostasis, particularly interest is given to their functions in adipose tissue expansion and obesity. Obesity-driven low-grade chronic inflammation, reduction of oxygen level in adipose tissue and engagement of bone marrow, support recruitment of various progenitor cells in adipose tissue. Activation of bone marrow-adipose tissue axis regulates hematopoiesis and infiltration of immune cells in adipose tissue. Obesity-associated factors can provoke alteration of ASPC multipotent differentiation and immunosuppressive potential. Determination of underpinning mechanisms in altered (obese) ASPC phenotype may contribute to development of novel approaches for treatment of metabolic disorders and advancement the safety and efficiency of adipose tissue grafting.",
journal = "Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry",
title = "Obesity: An emerging importance of progenitors",
pages = "160-148",
number = "3",
volume = "16",
doi = "10.2174/1871522217666170105092757"
}
Trivanović, D., Krstić, J., Santibanez, J., Jauković, A.,& Bugarski, D.. (2016). Obesity: An emerging importance of progenitors. in Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry, 16(3), 148-160.
https://doi.org/10.2174/1871522217666170105092757
conv_5106
Trivanović D, Krstić J, Santibanez J, Jauković A, Bugarski D. Obesity: An emerging importance of progenitors. in Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry. 2016;16(3):148-160.
doi:10.2174/1871522217666170105092757
conv_5106 .
Trivanović, Drenka, Krstić, Jelena, Santibanez, Juan, Jauković, Aleksandra, Bugarski, Diana, "Obesity: An emerging importance of progenitors" in Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry, 16, no. 3 (2016):148-160,
https://doi.org/10.2174/1871522217666170105092757 .,
conv_5106 .
