Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress
2016
Аутори
Mihailović-Stanojević, NevenaMiloradović, Zoran
Ivanov, Milan
Bugarski, Branko
Jovović, Đurđica
Karanović, Danijela
Vajić, Una Jovana
Komes, Draženka
Grujić-Milanović, Jelica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
High blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The... obtained results promote wild thyme as useful supplement for cardiovascular interventions.
Извор:
Oxidative Medicine & Cellular Longevity, 2016, 2016Издавач:
- Hindawi Ltd, London
Финансирање / пројекти:
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.1155/2016/1458793
ISSN: 1942-0900
PubMed: 27774115
WoS: 000385101300001
Scopus: 2-s2.0-84991387659
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Mihailović-Stanojević, Nevena AU - Miloradović, Zoran AU - Ivanov, Milan AU - Bugarski, Branko AU - Jovović, Đurđica AU - Karanović, Danijela AU - Vajić, Una Jovana AU - Komes, Draženka AU - Grujić-Milanović, Jelica PY - 2016 UR - http://rimi.imi.bg.ac.rs/handle/123456789/694 AB - High blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The obtained results promote wild thyme as useful supplement for cardiovascular interventions. PB - Hindawi Ltd, London T2 - Oxidative Medicine & Cellular Longevity T1 - Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress VL - 2016 DO - 10.1155/2016/1458793 ER -
@article{ author = "Mihailović-Stanojević, Nevena and Miloradović, Zoran and Ivanov, Milan and Bugarski, Branko and Jovović, Đurđica and Karanović, Danijela and Vajić, Una Jovana and Komes, Draženka and Grujić-Milanović, Jelica", year = "2016", abstract = "High blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The obtained results promote wild thyme as useful supplement for cardiovascular interventions.", publisher = "Hindawi Ltd, London", journal = "Oxidative Medicine & Cellular Longevity", title = "Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress", volume = "2016", doi = "10.1155/2016/1458793" }
Mihailović-Stanojević, N., Miloradović, Z., Ivanov, M., Bugarski, B., Jovović, Đ., Karanović, D., Vajić, U. J., Komes, D.,& Grujić-Milanović, J.. (2016). Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress. in Oxidative Medicine & Cellular Longevity Hindawi Ltd, London., 2016. https://doi.org/10.1155/2016/1458793
Mihailović-Stanojević N, Miloradović Z, Ivanov M, Bugarski B, Jovović Đ, Karanović D, Vajić UJ, Komes D, Grujić-Milanović J. Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress. in Oxidative Medicine & Cellular Longevity. 2016;2016. doi:10.1155/2016/1458793 .
Mihailović-Stanojević, Nevena, Miloradović, Zoran, Ivanov, Milan, Bugarski, Branko, Jovović, Đurđica, Karanović, Danijela, Vajić, Una Jovana, Komes, Draženka, Grujić-Milanović, Jelica, "Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress" in Oxidative Medicine & Cellular Longevity, 2016 (2016), https://doi.org/10.1155/2016/1458793 . .