Moderate consumption of alcohol-free red wine provide more beneficial effects on systemic haemodynamics, lipid profile and oxidative stress in spontaneously hypertensive rats than red wine
Само за регистроване кориснике
2016
Аутори
Mihailović-Stanojević, NevenaSavikin, Katarina
Živković, Jelena
Zdunić, Gordana
Miloradović, Zoran
Ivanov, Milan
Karanović, Danijela
Vajić, Una Jovana
Jovović, Đurđica
Grujić-Milanović, Jelica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Numerous studies have shown that moderate wine consumption is associated with decreased incidence of cardiovascular disease, including hypertension. Others observed that moderate alcohol consumption lowers the risk of cardiovascular events. The aim of the present study was to identify and quantify the components of red wine (RW) and alcohol-free red wine (AFRW), and compare the effects of their 4-week consumption (1 mL/day) on haemodynamics, lipid profile and oxidative stress in adult male spontaneously hypertensive rats (SHR). Among anthocyanins, malvidin 3-O-glucoside dominates in both RW and AFRW. AFRW reduces blood pressure of SHR. Both RW and AFRW can increase antioxidant capacity and reduce susceptibility of plasma to lipid peroxidation. RW, due to adverse triacylglycerol levels elevates the risk of cardiovascular complications in SHR. Removing alcohol from wine eliminates these adverse effects and promotes AFRW as a useful beverage in hypertensive patients.
Кључне речи:
Alcohol-free red wine / Anthocyanins / Malvidin-3-O-glucoside / Blood pressure / Oxidative stress / MagnesiumИзвор:
Journal of Functional Foods, 2016, 26, 719-730Издавач:
- Elsevier Science Bv, Amsterdam
Финансирање / пројекти:
- Традиционални и нови производи од плодова гајених и самониклих врста воћака и винове лозе и нус-продуката у преради, са посебним освртом на аутохтоне сорте: хемијска карактеризација и биолошки профил (RS-46013)
- Испитивање антихипертензивног и ренопротективног потенцијала супстанци природног и синтетског порекла у експерименталним моделима кардиоваскуларних и бубрежних обољења (RS-175096)
DOI: 10.1016/j.jff.2016.08.051
ISSN: 1756-4646
WoS: 000386193400066
Scopus: 2-s2.0-84986322534
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Mihailović-Stanojević, Nevena AU - Savikin, Katarina AU - Živković, Jelena AU - Zdunić, Gordana AU - Miloradović, Zoran AU - Ivanov, Milan AU - Karanović, Danijela AU - Vajić, Una Jovana AU - Jovović, Đurđica AU - Grujić-Milanović, Jelica PY - 2016 UR - http://rimi.imi.bg.ac.rs/handle/123456789/691 AB - Numerous studies have shown that moderate wine consumption is associated with decreased incidence of cardiovascular disease, including hypertension. Others observed that moderate alcohol consumption lowers the risk of cardiovascular events. The aim of the present study was to identify and quantify the components of red wine (RW) and alcohol-free red wine (AFRW), and compare the effects of their 4-week consumption (1 mL/day) on haemodynamics, lipid profile and oxidative stress in adult male spontaneously hypertensive rats (SHR). Among anthocyanins, malvidin 3-O-glucoside dominates in both RW and AFRW. AFRW reduces blood pressure of SHR. Both RW and AFRW can increase antioxidant capacity and reduce susceptibility of plasma to lipid peroxidation. RW, due to adverse triacylglycerol levels elevates the risk of cardiovascular complications in SHR. Removing alcohol from wine eliminates these adverse effects and promotes AFRW as a useful beverage in hypertensive patients. PB - Elsevier Science Bv, Amsterdam T2 - Journal of Functional Foods T1 - Moderate consumption of alcohol-free red wine provide more beneficial effects on systemic haemodynamics, lipid profile and oxidative stress in spontaneously hypertensive rats than red wine EP - 730 SP - 719 VL - 26 DO - 10.1016/j.jff.2016.08.051 ER -
@article{ author = "Mihailović-Stanojević, Nevena and Savikin, Katarina and Živković, Jelena and Zdunić, Gordana and Miloradović, Zoran and Ivanov, Milan and Karanović, Danijela and Vajić, Una Jovana and Jovović, Đurđica and Grujić-Milanović, Jelica", year = "2016", abstract = "Numerous studies have shown that moderate wine consumption is associated with decreased incidence of cardiovascular disease, including hypertension. Others observed that moderate alcohol consumption lowers the risk of cardiovascular events. The aim of the present study was to identify and quantify the components of red wine (RW) and alcohol-free red wine (AFRW), and compare the effects of their 4-week consumption (1 mL/day) on haemodynamics, lipid profile and oxidative stress in adult male spontaneously hypertensive rats (SHR). Among anthocyanins, malvidin 3-O-glucoside dominates in both RW and AFRW. AFRW reduces blood pressure of SHR. Both RW and AFRW can increase antioxidant capacity and reduce susceptibility of plasma to lipid peroxidation. RW, due to adverse triacylglycerol levels elevates the risk of cardiovascular complications in SHR. Removing alcohol from wine eliminates these adverse effects and promotes AFRW as a useful beverage in hypertensive patients.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Journal of Functional Foods", title = "Moderate consumption of alcohol-free red wine provide more beneficial effects on systemic haemodynamics, lipid profile and oxidative stress in spontaneously hypertensive rats than red wine", pages = "730-719", volume = "26", doi = "10.1016/j.jff.2016.08.051" }
Mihailović-Stanojević, N., Savikin, K., Živković, J., Zdunić, G., Miloradović, Z., Ivanov, M., Karanović, D., Vajić, U. J., Jovović, Đ.,& Grujić-Milanović, J.. (2016). Moderate consumption of alcohol-free red wine provide more beneficial effects on systemic haemodynamics, lipid profile and oxidative stress in spontaneously hypertensive rats than red wine. in Journal of Functional Foods Elsevier Science Bv, Amsterdam., 26, 719-730. https://doi.org/10.1016/j.jff.2016.08.051
Mihailović-Stanojević N, Savikin K, Živković J, Zdunić G, Miloradović Z, Ivanov M, Karanović D, Vajić UJ, Jovović Đ, Grujić-Milanović J. Moderate consumption of alcohol-free red wine provide more beneficial effects on systemic haemodynamics, lipid profile and oxidative stress in spontaneously hypertensive rats than red wine. in Journal of Functional Foods. 2016;26:719-730. doi:10.1016/j.jff.2016.08.051 .
Mihailović-Stanojević, Nevena, Savikin, Katarina, Živković, Jelena, Zdunić, Gordana, Miloradović, Zoran, Ivanov, Milan, Karanović, Danijela, Vajić, Una Jovana, Jovović, Đurđica, Grujić-Milanović, Jelica, "Moderate consumption of alcohol-free red wine provide more beneficial effects on systemic haemodynamics, lipid profile and oxidative stress in spontaneously hypertensive rats than red wine" in Journal of Functional Foods, 26 (2016):719-730, https://doi.org/10.1016/j.jff.2016.08.051 . .