Приказ основних података о документу

dc.creatorJovčić, Gordana
dc.creatorBugarski, Diana
dc.creatorPetakov, Marijana
dc.creatorStanković, J
dc.creatorStojanović, N.
dc.creatorMilenković, P.
dc.date.accessioned2021-04-20T12:06:01Z
dc.date.available2021-04-20T12:06:01Z
dc.date.issued2001
dc.identifier.issn0897-7194
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/68
dc.description.abstractThe influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hematopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.rightsrestrictedAccess
dc.sourceGrowth Factors
dc.subjectIL-17en
dc.subjecthematopoietic progenitorsen
dc.subjectcytokine releaseen
dc.subjectmurine bone marrowen
dc.titleEffect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrowen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage71
dc.citation.issue1
dc.citation.other19(1): 61-71
dc.citation.rankM22
dc.citation.spage61
dc.citation.volume19
dc.identifier.doi10.3109/08977190109001076
dc.identifier.pmid11678210
dc.identifier.scopus2-s2.0-0034795602
dc.identifier.wos000171616200005
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу