Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow
Само за регистроване кориснике
2001
Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
The influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hem...atopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism.
Кључне речи:
IL-17 / hematopoietic progenitors / cytokine release / murine bone marrowИзвор:
Growth Factors, 2001, 19, 1, 61-71Издавач:
- Taylor & Francis Ltd, Abingdon
DOI: 10.3109/08977190109001076
ISSN: 0897-7194
PubMed: 11678210
WoS: 000171616200005
Scopus: 2-s2.0-0034795602
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Jovčić, Gordana AU - Bugarski, Diana AU - Petakov, Marijana AU - Stanković, J AU - Stojanović, N. AU - Milenković, P. PY - 2001 UR - http://rimi.imi.bg.ac.rs/handle/123456789/68 AB - The influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hematopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism. PB - Taylor & Francis Ltd, Abingdon T2 - Growth Factors T1 - Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow EP - 71 IS - 1 SP - 61 VL - 19 DO - 10.3109/08977190109001076 ER -
@article{ author = "Jovčić, Gordana and Bugarski, Diana and Petakov, Marijana and Stanković, J and Stojanović, N. and Milenković, P.", year = "2001", abstract = "The influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hematopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Growth Factors", title = "Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow", pages = "71-61", number = "1", volume = "19", doi = "10.3109/08977190109001076" }
Jovčić, G., Bugarski, D., Petakov, M., Stanković, J., Stojanović, N.,& Milenković, P.. (2001). Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow. in Growth Factors Taylor & Francis Ltd, Abingdon., 19(1), 61-71. https://doi.org/10.3109/08977190109001076
Jovčić G, Bugarski D, Petakov M, Stanković J, Stojanović N, Milenković P. Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow. in Growth Factors. 2001;19(1):61-71. doi:10.3109/08977190109001076 .
Jovčić, Gordana, Bugarski, Diana, Petakov, Marijana, Stanković, J, Stojanović, N., Milenković, P., "Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow" in Growth Factors, 19, no. 1 (2001):61-71, https://doi.org/10.3109/08977190109001076 . .