The influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hem...atopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism.
TY - JOUR
AU - Jovčić, Gordana
AU - Bugarski, Diana
AU - Petakov, Marijana
AU - Stanković, J
AU - Stojanović, N.
AU - Milenković, P.
PY - 2001
UR - http://rimi.imi.bg.ac.rs/handle/123456789/68
AB - The influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hematopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism.
PB - Taylor & Francis Ltd, Abingdon
T2 - Growth Factors
T1 - Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow
EP - 71
IS - 1
SP - 61
VL - 19
DO - 10.3109/08977190109001076
ER -
@article{
author = "Jovčić, Gordana and Bugarski, Diana and Petakov, Marijana and Stanković, J and Stojanović, N. and Milenković, P.",
year = "2001",
abstract = "The influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hematopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Growth Factors",
title = "Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow",
pages = "71-61",
number = "1",
volume = "19",
doi = "10.3109/08977190109001076"
}
Jovčić, G., Bugarski, D., Petakov, M., Stanković, J., Stojanović, N.,& Milenković, P.. (2001). Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow. in Growth Factors
Taylor & Francis Ltd, Abingdon., 19(1), 61-71.
https://doi.org/10.3109/08977190109001076
Jovčić G, Bugarski D, Petakov M, Stanković J, Stojanović N, Milenković P. Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow. in Growth Factors. 2001;19(1):61-71.
doi:10.3109/08977190109001076 .
Jovčić, Gordana, Bugarski, Diana, Petakov, Marijana, Stanković, J, Stojanović, N., Milenković, P., "Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow" in Growth Factors, 19, no. 1 (2001):61-71,
https://doi.org/10.3109/08977190109001076 . .
