Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in activity of excitatory and inhibitory systems as well as redox homeostasis. Our aim was to investigate the effect of single (SS) and repeated session (RS) of intermittentand continuous theta-burst stimulation (iTBS; cTBS) on the expression of vesicular and plasmatic glutamate transporters 1 (vGluT1 and GLT-1), glial fibrillary acidic protein (GFAP) and influence on oxidative status in rats cerebellar tissue and plasma. Redox state parameters in cerebellar tissue and plasma were assessed 24 h after single and 48 h after the last TBS session. Molecular changes were examined by immunofluorescence. Stimulation significantly increased thiol groups (SH) in tissue of SS iTBS group, and decreased in iTBS RS. Activity of glucose-6-phosphate-dehydrogenase (G6PD) was increased markedly in cTBS RS. Immunoreactivity of vGluT1 in cTBS RS decreased, while GLT-1 increased in cTBS SS and cTBS RS, co...mpared to control. Present study gives insight in molecular and biochemical mechanisms by which iTBS and cTBS exerts its effects on rats cerebellar cortex.
TY - JOUR
AU - Mancić, Bojana
AU - Stevanović, Ivana
AU - Ilić, Tihomir V.
AU - Đurić, Ana
AU - Stojanović, Ivana
AU - Milanović, Slađan
AU - Ninković, Milica
PY - 2016
UR - http://rimi.imi.bg.ac.rs/handle/123456789/687
AB - Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in activity of excitatory and inhibitory systems as well as redox homeostasis. Our aim was to investigate the effect of single (SS) and repeated session (RS) of intermittentand continuous theta-burst stimulation (iTBS; cTBS) on the expression of vesicular and plasmatic glutamate transporters 1 (vGluT1 and GLT-1), glial fibrillary acidic protein (GFAP) and influence on oxidative status in rats cerebellar tissue and plasma. Redox state parameters in cerebellar tissue and plasma were assessed 24 h after single and 48 h after the last TBS session. Molecular changes were examined by immunofluorescence. Stimulation significantly increased thiol groups (SH) in tissue of SS iTBS group, and decreased in iTBS RS. Activity of glucose-6-phosphate-dehydrogenase (G6PD) was increased markedly in cTBS RS. Immunoreactivity of vGluT1 in cTBS RS decreased, while GLT-1 increased in cTBS SS and cTBS RS, compared to control. Present study gives insight in molecular and biochemical mechanisms by which iTBS and cTBS exerts its effects on rats cerebellar cortex.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Neurochemistry International
T1 - Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex
EP - 127
SP - 120
VL - 100
DO - 10.1016/j.neuint.2016.09.009
ER -
@article{
author = "Mancić, Bojana and Stevanović, Ivana and Ilić, Tihomir V. and Đurić, Ana and Stojanović, Ivana and Milanović, Slađan and Ninković, Milica",
year = "2016",
abstract = "Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in activity of excitatory and inhibitory systems as well as redox homeostasis. Our aim was to investigate the effect of single (SS) and repeated session (RS) of intermittentand continuous theta-burst stimulation (iTBS; cTBS) on the expression of vesicular and plasmatic glutamate transporters 1 (vGluT1 and GLT-1), glial fibrillary acidic protein (GFAP) and influence on oxidative status in rats cerebellar tissue and plasma. Redox state parameters in cerebellar tissue and plasma were assessed 24 h after single and 48 h after the last TBS session. Molecular changes were examined by immunofluorescence. Stimulation significantly increased thiol groups (SH) in tissue of SS iTBS group, and decreased in iTBS RS. Activity of glucose-6-phosphate-dehydrogenase (G6PD) was increased markedly in cTBS RS. Immunoreactivity of vGluT1 in cTBS RS decreased, while GLT-1 increased in cTBS SS and cTBS RS, compared to control. Present study gives insight in molecular and biochemical mechanisms by which iTBS and cTBS exerts its effects on rats cerebellar cortex.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Neurochemistry International",
title = "Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex",
pages = "127-120",
volume = "100",
doi = "10.1016/j.neuint.2016.09.009"
}
Mancić, B., Stevanović, I., Ilić, T. V., Đurić, A., Stojanović, I., Milanović, S.,& Ninković, M.. (2016). Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex. in Neurochemistry International
Pergamon-Elsevier Science Ltd, Oxford., 100, 120-127.
https://doi.org/10.1016/j.neuint.2016.09.009
Mancić B, Stevanović I, Ilić TV, Đurić A, Stojanović I, Milanović S, Ninković M. Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex. in Neurochemistry International. 2016;100:120-127.
doi:10.1016/j.neuint.2016.09.009 .
Mancić, Bojana, Stevanović, Ivana, Ilić, Tihomir V., Đurić, Ana, Stojanović, Ivana, Milanović, Slađan, Ninković, Milica, "Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex" in Neurochemistry International, 100 (2016):120-127,
https://doi.org/10.1016/j.neuint.2016.09.009 . .
