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Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow

Authorized Users Only
2001
Authors
Jovčić, Gordana
Bugarski, Diana
Petakov, Marijana
Stanković, J
Stojanović, N.
Milenković, P.
Article (Published version)
Metadata
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Abstract
The influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hem...atopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism.

Keywords:
IL-17 / hematopoietic progenitors / cytokine release / murine bone marrow
Source:
Growth Factors, 2001, 19, 1, 61-71
Publisher:
  • Taylor & Francis Ltd, Abingdon

DOI: 10.3109/08977190109001076

ISSN: 0897-7194

PubMed: 11678210

WoS: 000171616200005

Scopus: 2-s2.0-0034795602
[ Google Scholar ]
21
19
URI
http://rimi.imi.bg.ac.rs/handle/123456789/68
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Jovčić, Gordana
AU  - Bugarski, Diana
AU  - Petakov, Marijana
AU  - Stanković, J
AU  - Stojanović, N.
AU  - Milenković, P.
PY  - 2001
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/68
AB  - The influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hematopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Growth Factors
T1  - Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow
EP  - 71
IS  - 1
SP  - 61
VL  - 19
DO  - 10.3109/08977190109001076
UR  - conv_1399
ER  - 
@article{
author = "Jovčić, Gordana and Bugarski, Diana and Petakov, Marijana and Stanković, J and Stojanović, N. and Milenković, P.",
year = "2001",
abstract = "The influence of recombinant human IL-17 on granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitors and the release of IL-1 alpha/beta, IL-6 and erythropoietin (EPO) was estimated in the bone marrow cells obtained from normal and sublethally irradiated mice. In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO. In irradiated mice the effects of IL-17 on hematopoietic progenitors were lineage-dependent, as well as dependent on their stage of differentiation and the time after the irradiation. IL-17 had no major effects on CFU-GM on day 1 and 3, but decreased their number on day 2, while enhanced both BFU-E and CFU-E on day 1 and 2 after irradiation, whereas on day 3 its effect on erythroid progenitors was again as observed in normal mice. After irradiation, IL-17 increased the release of IL-1 alpha, IL-6 and EPO. The observed effects suggested the involvement of IL-17 in the regulation of hematopoiesis and indicated that its effects on both hematopoictic progenitors and cytokine release are dependent on the physiological/pathological status of the organism.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Growth Factors",
title = "Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow",
pages = "71-61",
number = "1",
volume = "19",
doi = "10.3109/08977190109001076",
url = "conv_1399"
}
Jovčić, G., Bugarski, D., Petakov, M., Stanković, J., Stojanović, N.,& Milenković, P.. (2001). Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow. in Growth Factors
Taylor & Francis Ltd, Abingdon., 19(1), 61-71.
https://doi.org/10.3109/08977190109001076
conv_1399
Jovčić G, Bugarski D, Petakov M, Stanković J, Stojanović N, Milenković P. Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow. in Growth Factors. 2001;19(1):61-71.
doi:10.3109/08977190109001076
conv_1399 .
Jovčić, Gordana, Bugarski, Diana, Petakov, Marijana, Stanković, J, Stojanović, N., Milenković, P., "Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow" in Growth Factors, 19, no. 1 (2001):61-71,
https://doi.org/10.3109/08977190109001076 .,
conv_1399 .

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