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An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling
dc.creator | Krstić, Jelena | |
dc.creator | Obradović, Hristina | |
dc.creator | Kukolj, Tamara | |
dc.creator | Mojsilović, Slavko | |
dc.creator | Okić Đorđević, Ivana | |
dc.creator | Bugarski, Diana | |
dc.creator | Santibanez, Juan F. | |
dc.date.accessioned | 2021-04-20T12:46:04Z | |
dc.date.available | 2021-04-20T12:46:04Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0929-8665 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/679 | |
dc.description.abstract | Interleukin-17A (IL-17A) and its receptor (IL-17RA) are prototype members of IL-17 ligand/receptor family firstly identified in CD4(+) T cells, which comprises six ligands (IL-17A to IL-17F) and five receptors (IL-17RA to IL-17RE). IL-17A is predominantly secreted by T helper 17 (Th17) cells, and plays important roles in the development of autoimmune and inflammatory diseases. IL-17RA is widely expressed, and forms a complex with IL-17RC. Binding of IL-17A to this receptor complex triggers the activation of several intracellular signaling pathways. In this review, we aimed to summarize literature data about molecular features of IL-17A and IL-17RA from gene to mature protein. We are also providing insight into regulatory mechanisms, protein structural conformation, including ligand-receptor interaction, and an overview of signaling pathways. Our aim was to compile the data on molecular characteristics of IL-17A and IL-17RA which may help in the understanding of their functions in health and disease. | en |
dc.publisher | Bentham Science Publ Ltd, Sharjah | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS// | |
dc.rights | restrictedAccess | |
dc.source | Protein & Peptide Letters | |
dc.subject | Expression | en |
dc.subject | Interleukin-17 | en |
dc.subject | interleukin-17 receptor A | en |
dc.subject | receptor interaction | en |
dc.subject | regulation | en |
dc.subject | signaling pathways | en |
dc.title | An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 578 | |
dc.citation.issue | 7 | |
dc.citation.other | 22(7): 570-578 | |
dc.citation.rank | M23 | |
dc.citation.spage | 570 | |
dc.citation.volume | 22 | |
dc.identifier.doi | 10.2174/0929866522666150520145554 | |
dc.identifier.pmid | 25990083 | |
dc.identifier.scopus | 2-s2.0-84934295415 | |
dc.identifier.wos | 000356520900001 | |
dc.type.version | publishedVersion |
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