Приказ основних података о документу

dc.creatorKrstić, Jelena
dc.creatorObradović, Hristina
dc.creatorKukolj, Tamara
dc.creatorMojsilović, Slavko
dc.creatorOkić Đorđević, Ivana
dc.creatorBugarski, Diana
dc.creatorSantibanez, Juan F.
dc.date.accessioned2021-04-20T12:46:04Z
dc.date.available2021-04-20T12:46:04Z
dc.date.issued2015
dc.identifier.issn0929-8665
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/679
dc.description.abstractInterleukin-17A (IL-17A) and its receptor (IL-17RA) are prototype members of IL-17 ligand/receptor family firstly identified in CD4(+) T cells, which comprises six ligands (IL-17A to IL-17F) and five receptors (IL-17RA to IL-17RE). IL-17A is predominantly secreted by T helper 17 (Th17) cells, and plays important roles in the development of autoimmune and inflammatory diseases. IL-17RA is widely expressed, and forms a complex with IL-17RC. Binding of IL-17A to this receptor complex triggers the activation of several intracellular signaling pathways. In this review, we aimed to summarize literature data about molecular features of IL-17A and IL-17RA from gene to mature protein. We are also providing insight into regulatory mechanisms, protein structural conformation, including ligand-receptor interaction, and an overview of signaling pathways. Our aim was to compile the data on molecular characteristics of IL-17A and IL-17RA which may help in the understanding of their functions in health and disease.en
dc.publisherBentham Science Publ Ltd, Sharjah
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS//
dc.rightsrestrictedAccess
dc.sourceProtein & Peptide Letters
dc.subjectExpressionen
dc.subjectInterleukin-17en
dc.subjectinterleukin-17 receptor Aen
dc.subjectreceptor interactionen
dc.subjectregulationen
dc.subjectsignaling pathwaysen
dc.titleAn Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signalingen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage578
dc.citation.issue7
dc.citation.other22(7): 570-578
dc.citation.rankM23
dc.citation.spage570
dc.citation.volume22
dc.identifier.doi10.2174/0929866522666150520145554
dc.identifier.pmid25990083
dc.identifier.scopus2-s2.0-84934295415
dc.identifier.wos000356520900001
dc.type.versionpublishedVersion


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