Interleukin-17A (IL-17A) and its receptor (IL-17RA) are prototype members of IL-17 ligand/receptor family firstly identified in CD4(+) T cells, which comprises six ligands (IL-17A to IL-17F) and five receptors (IL-17RA to IL-17RE). IL-17A is predominantly secreted by T helper 17 (Th17) cells, and plays important roles in the development of autoimmune and inflammatory diseases. IL-17RA is widely expressed, and forms a complex with IL-17RC. Binding of IL-17A to this receptor complex triggers the activation of several intracellular signaling pathways. In this review, we aimed to summarize literature data about molecular features of IL-17A and IL-17RA from gene to mature protein. We are also providing insight into regulatory mechanisms, protein structural conformation, including ligand-receptor interaction, and an overview of signaling pathways. Our aim was to compile the data on molecular characteristics of IL-17A and IL-17RA which may help in the understanding of their functions in healt...h and disease.
TY - JOUR
AU - Krstić, Jelena
AU - Obradović, Hristina
AU - Kukolj, Tamara
AU - Mojsilović, Slavko
AU - Okić-Đorđević, Ivana
AU - Bugarski, Diana
AU - Santibanez, Juan
PY - 2015
UR - http://rimi.imi.bg.ac.rs/handle/123456789/679
AB - Interleukin-17A (IL-17A) and its receptor (IL-17RA) are prototype members of IL-17 ligand/receptor family firstly identified in CD4(+) T cells, which comprises six ligands (IL-17A to IL-17F) and five receptors (IL-17RA to IL-17RE). IL-17A is predominantly secreted by T helper 17 (Th17) cells, and plays important roles in the development of autoimmune and inflammatory diseases. IL-17RA is widely expressed, and forms a complex with IL-17RC. Binding of IL-17A to this receptor complex triggers the activation of several intracellular signaling pathways. In this review, we aimed to summarize literature data about molecular features of IL-17A and IL-17RA from gene to mature protein. We are also providing insight into regulatory mechanisms, protein structural conformation, including ligand-receptor interaction, and an overview of signaling pathways. Our aim was to compile the data on molecular characteristics of IL-17A and IL-17RA which may help in the understanding of their functions in health and disease.
PB - Bentham Science Publ Ltd, Sharjah
T2 - Protein & Peptide Letters
T1 - An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling
EP - 578
IS - 7
SP - 570
VL - 22
DO - 10.2174/0929866522666150520145554
UR - conv_3523
ER -
@article{
author = "Krstić, Jelena and Obradović, Hristina and Kukolj, Tamara and Mojsilović, Slavko and Okić-Đorđević, Ivana and Bugarski, Diana and Santibanez, Juan",
year = "2015",
abstract = "Interleukin-17A (IL-17A) and its receptor (IL-17RA) are prototype members of IL-17 ligand/receptor family firstly identified in CD4(+) T cells, which comprises six ligands (IL-17A to IL-17F) and five receptors (IL-17RA to IL-17RE). IL-17A is predominantly secreted by T helper 17 (Th17) cells, and plays important roles in the development of autoimmune and inflammatory diseases. IL-17RA is widely expressed, and forms a complex with IL-17RC. Binding of IL-17A to this receptor complex triggers the activation of several intracellular signaling pathways. In this review, we aimed to summarize literature data about molecular features of IL-17A and IL-17RA from gene to mature protein. We are also providing insight into regulatory mechanisms, protein structural conformation, including ligand-receptor interaction, and an overview of signaling pathways. Our aim was to compile the data on molecular characteristics of IL-17A and IL-17RA which may help in the understanding of their functions in health and disease.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Protein & Peptide Letters",
title = "An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling",
pages = "578-570",
number = "7",
volume = "22",
doi = "10.2174/0929866522666150520145554",
url = "conv_3523"
}
Krstić, J., Obradović, H., Kukolj, T., Mojsilović, S., Okić-Đorđević, I., Bugarski, D.,& Santibanez, J.. (2015). An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling. in Protein & Peptide Letters
Bentham Science Publ Ltd, Sharjah., 22(7), 570-578.
https://doi.org/10.2174/0929866522666150520145554
conv_3523
Krstić J, Obradović H, Kukolj T, Mojsilović S, Okić-Đorđević I, Bugarski D, Santibanez J. An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling. in Protein & Peptide Letters. 2015;22(7):570-578.
doi:10.2174/0929866522666150520145554
conv_3523 .
Krstić, Jelena, Obradović, Hristina, Kukolj, Tamara, Mojsilović, Slavko, Okić-Đorđević, Ivana, Bugarski, Diana, Santibanez, Juan, "An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling" in Protein & Peptide Letters, 22, no. 7 (2015):570-578,
https://doi.org/10.2174/0929866522666150520145554 .,
conv_3523 .
