Experimental pain processing in individuals with cognitive impairment: current state of the science
Nema prikaza
Autori
Defrin, RuthAmanzio, Martina
de Tommaso, Marina
Dimova, Violeta
Filipović, Saša
Finn, David P.
Gimenez-Llort, Lydia
Invitto, Sara
Jensen-Dahm, Christina
Lautenbacher, Stefan
Oosterman, Joukje M.
Petrini, Laura
Pick, Chaim G.
Pickering, Gisele
Vase, Lene
Kunz, Miriam
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Cognitive impairment (Cl) can develop during the course of ageing and is a feature of many neurological and neurodegenerative diseases. Many individuals with Cl have substantial, sustained, and complex health care needs, which frequently include pain. However, individuals With Cl can have difficulty communicating the features of their pain to others, which in turn presents a significant challenge for effective diagnosis and treatment of their pain. Herein, we review the literature on responsivity of individuals with Cl to experimental pain stimuli. We discuss pain responding across a large number of neurological and neurodegenerative disorders in which Cl is typically present. Overall, the existing data suggest that pain processing is altered in most individuals with Cl compared with cognitively intact matched controls. The precise nature of these alterations varies with the type of Cl (or associated clinical condition) and may also depend on the type of pain stimulation used and the t...ype of pain responses assessed. Nevertheless, it is clear that regardless of the etiology of Cl, patients do feel noxious stimuli, with more evidence for hypersensitivity than hyposensitivity to these stimuli compared with cognitively unimpaired individuals. Our current understanding of the neurobiological mechanisms underpinning these alterations is limited but may be enhanced through the use of animal models of Cl, which also exhibit alterations in nociceptive responding. Further research using additional behavioural indices of pain is warranted. Increased understanding of altered experimental pain processing in Cl will facilitate the development of improved diagnostic and therapeutic approaches for pain in individuals with Cl.
Ključne reči:
Cognitive impairment / Experimental pain / Dementia / Neurodegenerative disorders / Developmental disorders / Pain perceptionIzvor:
Pain, 2015, 156, 8, 1396-1408Izdavač:
- Lippincott Williams & Wilkins, Philadelphia
Finansiranje / projekti:
- COST action [TD1005]
Napomena:
- Peer-reviewed manuscript: http://rimi.imi.bg.ac.rs/handle/123456789/1131
DOI: 10.1097/j.pain.0000000000000195
ISSN: 0304-3959
PubMed: 26181216
WoS: 000358815500007
Scopus: 2-s2.0-84935025117
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Defrin, Ruth AU - Amanzio, Martina AU - de Tommaso, Marina AU - Dimova, Violeta AU - Filipović, Saša AU - Finn, David P. AU - Gimenez-Llort, Lydia AU - Invitto, Sara AU - Jensen-Dahm, Christina AU - Lautenbacher, Stefan AU - Oosterman, Joukje M. AU - Petrini, Laura AU - Pick, Chaim G. AU - Pickering, Gisele AU - Vase, Lene AU - Kunz, Miriam PY - 2015 UR - http://rimi.imi.bg.ac.rs/handle/123456789/671 AB - Cognitive impairment (Cl) can develop during the course of ageing and is a feature of many neurological and neurodegenerative diseases. Many individuals with Cl have substantial, sustained, and complex health care needs, which frequently include pain. However, individuals With Cl can have difficulty communicating the features of their pain to others, which in turn presents a significant challenge for effective diagnosis and treatment of their pain. Herein, we review the literature on responsivity of individuals with Cl to experimental pain stimuli. We discuss pain responding across a large number of neurological and neurodegenerative disorders in which Cl is typically present. Overall, the existing data suggest that pain processing is altered in most individuals with Cl compared with cognitively intact matched controls. The precise nature of these alterations varies with the type of Cl (or associated clinical condition) and may also depend on the type of pain stimulation used and the type of pain responses assessed. Nevertheless, it is clear that regardless of the etiology of Cl, patients do feel noxious stimuli, with more evidence for hypersensitivity than hyposensitivity to these stimuli compared with cognitively unimpaired individuals. Our current understanding of the neurobiological mechanisms underpinning these alterations is limited but may be enhanced through the use of animal models of Cl, which also exhibit alterations in nociceptive responding. Further research using additional behavioural indices of pain is warranted. Increased understanding of altered experimental pain processing in Cl will facilitate the development of improved diagnostic and therapeutic approaches for pain in individuals with Cl. PB - Lippincott Williams & Wilkins, Philadelphia T2 - Pain T1 - Experimental pain processing in individuals with cognitive impairment: current state of the science EP - 1408 IS - 8 SP - 1396 VL - 156 DO - 10.1097/j.pain.0000000000000195 ER -
@article{ author = "Defrin, Ruth and Amanzio, Martina and de Tommaso, Marina and Dimova, Violeta and Filipović, Saša and Finn, David P. and Gimenez-Llort, Lydia and Invitto, Sara and Jensen-Dahm, Christina and Lautenbacher, Stefan and Oosterman, Joukje M. and Petrini, Laura and Pick, Chaim G. and Pickering, Gisele and Vase, Lene and Kunz, Miriam", year = "2015", abstract = "Cognitive impairment (Cl) can develop during the course of ageing and is a feature of many neurological and neurodegenerative diseases. Many individuals with Cl have substantial, sustained, and complex health care needs, which frequently include pain. However, individuals With Cl can have difficulty communicating the features of their pain to others, which in turn presents a significant challenge for effective diagnosis and treatment of their pain. Herein, we review the literature on responsivity of individuals with Cl to experimental pain stimuli. We discuss pain responding across a large number of neurological and neurodegenerative disorders in which Cl is typically present. Overall, the existing data suggest that pain processing is altered in most individuals with Cl compared with cognitively intact matched controls. The precise nature of these alterations varies with the type of Cl (or associated clinical condition) and may also depend on the type of pain stimulation used and the type of pain responses assessed. Nevertheless, it is clear that regardless of the etiology of Cl, patients do feel noxious stimuli, with more evidence for hypersensitivity than hyposensitivity to these stimuli compared with cognitively unimpaired individuals. Our current understanding of the neurobiological mechanisms underpinning these alterations is limited but may be enhanced through the use of animal models of Cl, which also exhibit alterations in nociceptive responding. Further research using additional behavioural indices of pain is warranted. Increased understanding of altered experimental pain processing in Cl will facilitate the development of improved diagnostic and therapeutic approaches for pain in individuals with Cl.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "Pain", title = "Experimental pain processing in individuals with cognitive impairment: current state of the science", pages = "1408-1396", number = "8", volume = "156", doi = "10.1097/j.pain.0000000000000195" }
Defrin, R., Amanzio, M., de Tommaso, M., Dimova, V., Filipović, S., Finn, D. P., Gimenez-Llort, L., Invitto, S., Jensen-Dahm, C., Lautenbacher, S., Oosterman, J. M., Petrini, L., Pick, C. G., Pickering, G., Vase, L.,& Kunz, M.. (2015). Experimental pain processing in individuals with cognitive impairment: current state of the science. in Pain Lippincott Williams & Wilkins, Philadelphia., 156(8), 1396-1408. https://doi.org/10.1097/j.pain.0000000000000195
Defrin R, Amanzio M, de Tommaso M, Dimova V, Filipović S, Finn DP, Gimenez-Llort L, Invitto S, Jensen-Dahm C, Lautenbacher S, Oosterman JM, Petrini L, Pick CG, Pickering G, Vase L, Kunz M. Experimental pain processing in individuals with cognitive impairment: current state of the science. in Pain. 2015;156(8):1396-1408. doi:10.1097/j.pain.0000000000000195 .
Defrin, Ruth, Amanzio, Martina, de Tommaso, Marina, Dimova, Violeta, Filipović, Saša, Finn, David P., Gimenez-Llort, Lydia, Invitto, Sara, Jensen-Dahm, Christina, Lautenbacher, Stefan, Oosterman, Joukje M., Petrini, Laura, Pick, Chaim G., Pickering, Gisele, Vase, Lene, Kunz, Miriam, "Experimental pain processing in individuals with cognitive impairment: current state of the science" in Pain, 156, no. 8 (2015):1396-1408, https://doi.org/10.1097/j.pain.0000000000000195 . .