Limited numbers of studies include research of microvibration therapy in experimental models. We examined effects of chronic vibroacustic-microvibration treatment on haemodynamics and anti-oxidative defense in experimental hypertension. Study was performed on chronically treated hypertensive and normotensive Wistar rats. Mean arterial pressure (MAP), cardiac output (CO), renal blood flow (RBF), glomerular filtration and activity of anti-oxidative enzymes were determined after three weeks treatment. Vibroacustic treatment had no influence on MAP and CO, but RBF was increased in both groups of treated rats. Additionally, vibroacustic treatment enhanced diuresis and increased glomerular filtration in hypertensive rats. Glutathione peroxidase (GSH-Px) activity was elevated in both treated rat strains, but activity of superoxide dismutase was unchanged. We conclude that microvibration treatment doesn't ameliorate hypertension but improves renal blood supply (trough diminished renal vascular... resistance), glomerular filtration, diuresis, and enhances glutathione dependent anti-oxidant defense with more important beneficials in hypertensive animals.
TY - JOUR
AU - Miloradović, Zoran
AU - Mihailović-Stanojević, Nevena
AU - Jovović, Đurđica
AU - Ivanov, Milan
AU - Vajić, Una-Jovana
AU - Karanović, Danijela
AU - Grujić-Milanović, Jelica
PY - 2015
UR - http://rimi.imi.bg.ac.rs/handle/123456789/656
AB - Limited numbers of studies include research of microvibration therapy in experimental models. We examined effects of chronic vibroacustic-microvibration treatment on haemodynamics and anti-oxidative defense in experimental hypertension. Study was performed on chronically treated hypertensive and normotensive Wistar rats. Mean arterial pressure (MAP), cardiac output (CO), renal blood flow (RBF), glomerular filtration and activity of anti-oxidative enzymes were determined after three weeks treatment. Vibroacustic treatment had no influence on MAP and CO, but RBF was increased in both groups of treated rats. Additionally, vibroacustic treatment enhanced diuresis and increased glomerular filtration in hypertensive rats. Glutathione peroxidase (GSH-Px) activity was elevated in both treated rat strains, but activity of superoxide dismutase was unchanged. We conclude that microvibration treatment doesn't ameliorate hypertension but improves renal blood supply (trough diminished renal vascular resistance), glomerular filtration, diuresis, and enhances glutathione dependent anti-oxidant defense with more important beneficials in hypertensive animals.
PB - General Physiol And Biophysics, Bratislava
T2 - General Physiology & Biophysics
T1 - Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats
EP - 94
IS - 1
SP - 89
VL - 34
DO - 10.4149/gpb_2014033
ER -
@article{
author = "Miloradović, Zoran and Mihailović-Stanojević, Nevena and Jovović, Đurđica and Ivanov, Milan and Vajić, Una-Jovana and Karanović, Danijela and Grujić-Milanović, Jelica",
year = "2015",
abstract = "Limited numbers of studies include research of microvibration therapy in experimental models. We examined effects of chronic vibroacustic-microvibration treatment on haemodynamics and anti-oxidative defense in experimental hypertension. Study was performed on chronically treated hypertensive and normotensive Wistar rats. Mean arterial pressure (MAP), cardiac output (CO), renal blood flow (RBF), glomerular filtration and activity of anti-oxidative enzymes were determined after three weeks treatment. Vibroacustic treatment had no influence on MAP and CO, but RBF was increased in both groups of treated rats. Additionally, vibroacustic treatment enhanced diuresis and increased glomerular filtration in hypertensive rats. Glutathione peroxidase (GSH-Px) activity was elevated in both treated rat strains, but activity of superoxide dismutase was unchanged. We conclude that microvibration treatment doesn't ameliorate hypertension but improves renal blood supply (trough diminished renal vascular resistance), glomerular filtration, diuresis, and enhances glutathione dependent anti-oxidant defense with more important beneficials in hypertensive animals.",
publisher = "General Physiol And Biophysics, Bratislava",
journal = "General Physiology & Biophysics",
title = "Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats",
pages = "94-89",
number = "1",
volume = "34",
doi = "10.4149/gpb_2014033"
}
Miloradović, Z., Mihailović-Stanojević, N., Jovović, Đ., Ivanov, M., Vajić, U., Karanović, D.,& Grujić-Milanović, J.. (2015). Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats. in General Physiology & Biophysics
General Physiol And Biophysics, Bratislava., 34(1), 89-94.
https://doi.org/10.4149/gpb_2014033
conv_3435
Miloradović Z, Mihailović-Stanojević N, Jovović Đ, Ivanov M, Vajić U, Karanović D, Grujić-Milanović J. Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats. in General Physiology & Biophysics. 2015;34(1):89-94.
doi:10.4149/gpb_2014033
conv_3435 .
