Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens
Samo za registrovane korisnike
2015
Autori
Radović, IvanaGruden-Movsesijan, Alisa
Ilić, Nataša
Cvetković, Jelena
Mojsilović, Slavko
Dević, Marija
Sofronic-Milošavljević, Ljiljana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Helminth-derived products, either released into the circulation during the course of the infection or isolated after in vitro cultivation of the parasite and applied by the injection, are able to suppress the host immune response to autoantigens and allergens, but mechanisms could differ. Prophylactic application of Trichinella spiralis excretory-secretory muscle larvae (ES L1) products ameliorates experimental autoimmune encephalomyelitis (EAE) with the same success as infection did. However, a shift to the Th2-type response in the periphery and in the central nervous system, accompanied by activation of regulatory mechanisms, had a striking, new feature of increased proportion of unconventional CD4(+)CD25(-)Foxp3(+) regulatory cells both in the periphery and in the central nervous system of animals treated with ES L1 before the induction of EAE.
Ključne reči:
Trichinella spiralis / Excretory-secretory antigens / Experimental autoimmune encephalomyelitisIzvor:
Immunologic Research, 2015, 61, 3, 312-325Izdavač:
- Humana Press Inc, Totowa
Finansiranje / projekti:
- Izučavanje mehanizama imunskog odgovora na infekciju ili produkte parazita i njihov uticaj na modulaciju i/ili prevenciju drugih bolesti (RS-MESTD-Basic Research (BR or ON)-173047)
DOI: 10.1007/s12026-015-8626-4
ISSN: 0257-277X
PubMed: 25616617
WoS: 000350295900014
Scopus: 2-s2.0-84925506968
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Radović, Ivana AU - Gruden-Movsesijan, Alisa AU - Ilić, Nataša AU - Cvetković, Jelena AU - Mojsilović, Slavko AU - Dević, Marija AU - Sofronic-Milošavljević, Ljiljana PY - 2015 UR - http://rimi.imi.bg.ac.rs/handle/123456789/652 AB - Helminth-derived products, either released into the circulation during the course of the infection or isolated after in vitro cultivation of the parasite and applied by the injection, are able to suppress the host immune response to autoantigens and allergens, but mechanisms could differ. Prophylactic application of Trichinella spiralis excretory-secretory muscle larvae (ES L1) products ameliorates experimental autoimmune encephalomyelitis (EAE) with the same success as infection did. However, a shift to the Th2-type response in the periphery and in the central nervous system, accompanied by activation of regulatory mechanisms, had a striking, new feature of increased proportion of unconventional CD4(+)CD25(-)Foxp3(+) regulatory cells both in the periphery and in the central nervous system of animals treated with ES L1 before the induction of EAE. PB - Humana Press Inc, Totowa T2 - Immunologic Research T1 - Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens EP - 325 IS - 3 SP - 312 VL - 61 DO - 10.1007/s12026-015-8626-4 ER -
@article{ author = "Radović, Ivana and Gruden-Movsesijan, Alisa and Ilić, Nataša and Cvetković, Jelena and Mojsilović, Slavko and Dević, Marija and Sofronic-Milošavljević, Ljiljana", year = "2015", abstract = "Helminth-derived products, either released into the circulation during the course of the infection or isolated after in vitro cultivation of the parasite and applied by the injection, are able to suppress the host immune response to autoantigens and allergens, but mechanisms could differ. Prophylactic application of Trichinella spiralis excretory-secretory muscle larvae (ES L1) products ameliorates experimental autoimmune encephalomyelitis (EAE) with the same success as infection did. However, a shift to the Th2-type response in the periphery and in the central nervous system, accompanied by activation of regulatory mechanisms, had a striking, new feature of increased proportion of unconventional CD4(+)CD25(-)Foxp3(+) regulatory cells both in the periphery and in the central nervous system of animals treated with ES L1 before the induction of EAE.", publisher = "Humana Press Inc, Totowa", journal = "Immunologic Research", title = "Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens", pages = "325-312", number = "3", volume = "61", doi = "10.1007/s12026-015-8626-4" }
Radović, I., Gruden-Movsesijan, A., Ilić, N., Cvetković, J., Mojsilović, S., Dević, M.,& Sofronic-Milošavljević, L.. (2015). Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens. in Immunologic Research Humana Press Inc, Totowa., 61(3), 312-325. https://doi.org/10.1007/s12026-015-8626-4
Radović I, Gruden-Movsesijan A, Ilić N, Cvetković J, Mojsilović S, Dević M, Sofronic-Milošavljević L. Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens. in Immunologic Research. 2015;61(3):312-325. doi:10.1007/s12026-015-8626-4 .
Radović, Ivana, Gruden-Movsesijan, Alisa, Ilić, Nataša, Cvetković, Jelena, Mojsilović, Slavko, Dević, Marija, Sofronic-Milošavljević, Ljiljana, "Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens" in Immunologic Research, 61, no. 3 (2015):312-325, https://doi.org/10.1007/s12026-015-8626-4 . .