Helminth-derived products, either released into the circulation during the course of the infection or isolated after in vitro cultivation of the parasite and applied by the injection, are able to suppress the host immune response to autoantigens and allergens, but mechanisms could differ. Prophylactic application of Trichinella spiralis excretory-secretory muscle larvae (ES L1) products ameliorates experimental autoimmune encephalomyelitis (EAE) with the same success as infection did. However, a shift to the Th2-type response in the periphery and in the central nervous system, accompanied by activation of regulatory mechanisms, had a striking, new feature of increased proportion of unconventional CD4(+)CD25(-)Foxp3(+) regulatory cells both in the periphery and in the central nervous system of animals treated with ES L1 before the induction of EAE.
TY - JOUR
AU - Radović, Ivana
AU - Gruden-Movsesijan, Alisa
AU - Ilić, Nataša
AU - Cvetković, Jelena
AU - Mojsilović, Slavko
AU - Dević, Marija
AU - Sofronic-Milošavljević, Ljiljana
PY - 2015
UR - http://rimi.imi.bg.ac.rs/handle/123456789/652
AB - Helminth-derived products, either released into the circulation during the course of the infection or isolated after in vitro cultivation of the parasite and applied by the injection, are able to suppress the host immune response to autoantigens and allergens, but mechanisms could differ. Prophylactic application of Trichinella spiralis excretory-secretory muscle larvae (ES L1) products ameliorates experimental autoimmune encephalomyelitis (EAE) with the same success as infection did. However, a shift to the Th2-type response in the periphery and in the central nervous system, accompanied by activation of regulatory mechanisms, had a striking, new feature of increased proportion of unconventional CD4(+)CD25(-)Foxp3(+) regulatory cells both in the periphery and in the central nervous system of animals treated with ES L1 before the induction of EAE.
PB - Humana Press Inc, Totowa
T2 - Immunologic Research
T1 - Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens
EP - 325
IS - 3
SP - 312
VL - 61
DO - 10.1007/s12026-015-8626-4
UR - conv_3442
ER -
@article{
author = "Radović, Ivana and Gruden-Movsesijan, Alisa and Ilić, Nataša and Cvetković, Jelena and Mojsilović, Slavko and Dević, Marija and Sofronic-Milošavljević, Ljiljana",
year = "2015",
abstract = "Helminth-derived products, either released into the circulation during the course of the infection or isolated after in vitro cultivation of the parasite and applied by the injection, are able to suppress the host immune response to autoantigens and allergens, but mechanisms could differ. Prophylactic application of Trichinella spiralis excretory-secretory muscle larvae (ES L1) products ameliorates experimental autoimmune encephalomyelitis (EAE) with the same success as infection did. However, a shift to the Th2-type response in the periphery and in the central nervous system, accompanied by activation of regulatory mechanisms, had a striking, new feature of increased proportion of unconventional CD4(+)CD25(-)Foxp3(+) regulatory cells both in the periphery and in the central nervous system of animals treated with ES L1 before the induction of EAE.",
publisher = "Humana Press Inc, Totowa",
journal = "Immunologic Research",
title = "Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens",
pages = "325-312",
number = "3",
volume = "61",
doi = "10.1007/s12026-015-8626-4",
url = "conv_3442"
}
Radović, I., Gruden-Movsesijan, A., Ilić, N., Cvetković, J., Mojsilović, S., Dević, M.,& Sofronic-Milošavljević, L.. (2015). Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens. in Immunologic Research
Humana Press Inc, Totowa., 61(3), 312-325.
https://doi.org/10.1007/s12026-015-8626-4
conv_3442
Radović I, Gruden-Movsesijan A, Ilić N, Cvetković J, Mojsilović S, Dević M, Sofronic-Milošavljević L. Immunomodulatory effects of Trichinella spiralis-derived excretory-secretory antigens. in Immunologic Research. 2015;61(3):312-325.
doi:10.1007/s12026-015-8626-4
conv_3442 .
