Immunochemical identification of paraproteins in patients with malignant monoclonal gammapathies
Abstract
The study deals with the analysis of monoclonal immunoglobulins (paraproteins, M-components) in sera and urine of 52 patients with malignant monoclonal gammapathies. Toe examination included detection of paraproteins and immunochemical identification of their class, light chain type, kappa/lambda ratio, and subclass in the cases with bi- and triclonal variants. The observed distribution of isotypes and light chain types among paraproteins was different from that of normal serum immunoglobulins and that reported in literature. The results are discussed in the light of the current view of the problem of molecular phenomena in malignant monoclonal gammapathies and of their clinical significance.
Keywords:
paraproteins / malignant monoclonal gammapathiesSource:
Jugoslovenska Medicinska Biohemija - Yugoslav Medical Biochemistry, 2000, 19, 2, 109-114Publisher:
- Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
Collections
Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Ristić, T AU - Tosić, L AU - Ilić, Vesna AU - Ćirić, D AU - Đorđević, V. AU - Milošević-Jovčić, Nadežda PY - 2000 UR - http://rimi.imi.bg.ac.rs/handle/123456789/64 AB - The study deals with the analysis of monoclonal immunoglobulins (paraproteins, M-components) in sera and urine of 52 patients with malignant monoclonal gammapathies. Toe examination included detection of paraproteins and immunochemical identification of their class, light chain type, kappa/lambda ratio, and subclass in the cases with bi- and triclonal variants. The observed distribution of isotypes and light chain types among paraproteins was different from that of normal serum immunoglobulins and that reported in literature. The results are discussed in the light of the current view of the problem of molecular phenomena in malignant monoclonal gammapathies and of their clinical significance. PB - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd T2 - Jugoslovenska Medicinska Biohemija - Yugoslav Medical Biochemistry T1 - Immunochemical identification of paraproteins in patients with malignant monoclonal gammapathies EP - 114 IS - 2 SP - 109 VL - 19 UR - conv_1359 ER -
@article{ author = "Ristić, T and Tosić, L and Ilić, Vesna and Ćirić, D and Đorđević, V. and Milošević-Jovčić, Nadežda", year = "2000", abstract = "The study deals with the analysis of monoclonal immunoglobulins (paraproteins, M-components) in sera and urine of 52 patients with malignant monoclonal gammapathies. Toe examination included detection of paraproteins and immunochemical identification of their class, light chain type, kappa/lambda ratio, and subclass in the cases with bi- and triclonal variants. The observed distribution of isotypes and light chain types among paraproteins was different from that of normal serum immunoglobulins and that reported in literature. The results are discussed in the light of the current view of the problem of molecular phenomena in malignant monoclonal gammapathies and of their clinical significance.", publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd", journal = "Jugoslovenska Medicinska Biohemija - Yugoslav Medical Biochemistry", title = "Immunochemical identification of paraproteins in patients with malignant monoclonal gammapathies", pages = "114-109", number = "2", volume = "19", url = "conv_1359" }
Ristić, T., Tosić, L., Ilić, V., Ćirić, D., Đorđević, V.,& Milošević-Jovčić, N.. (2000). Immunochemical identification of paraproteins in patients with malignant monoclonal gammapathies. in Jugoslovenska Medicinska Biohemija - Yugoslav Medical Biochemistry Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 19(2), 109-114. conv_1359
Ristić T, Tosić L, Ilić V, Ćirić D, Đorđević V, Milošević-Jovčić N. Immunochemical identification of paraproteins in patients with malignant monoclonal gammapathies. in Jugoslovenska Medicinska Biohemija - Yugoslav Medical Biochemistry. 2000;19(2):109-114. conv_1359 .
Ristić, T, Tosić, L, Ilić, Vesna, Ćirić, D, Đorđević, V., Milošević-Jovčić, Nadežda, "Immunochemical identification of paraproteins in patients with malignant monoclonal gammapathies" in Jugoslovenska Medicinska Biohemija - Yugoslav Medical Biochemistry, 19, no. 2 (2000):109-114, conv_1359 .