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Effects of treatment with interleukin-1 receptor antagonist on endogenous interleukin-1 levels in normal and irradiated mice
dc.creator | Bugarski, Diana | |
dc.creator | Jovčić, Gordana | |
dc.creator | Kataranovski, Milena | |
dc.creator | Ivanović, Z | |
dc.creator | Petakov, Marijana | |
dc.creator | Stojanović, N. | |
dc.creator | Milenković, P. | |
dc.date.accessioned | 2021-04-20T12:05:33Z | |
dc.date.available | 2021-04-20T12:05:33Z | |
dc.date.issued | 2000 | |
dc.identifier.issn | 0862-8408 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/61 | |
dc.description.abstract | The in vivo effects of recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) administration on endogenous IL-1 levels in the circulation and conditioned media (CM) from different immunohematopoietic organ/tissues were studied in CBA mice under steady state and postirradiation conditions. In normal mice, constitutive IL-1 levels were demonstrated in the plasma, CM of peritoneal exudate cells and full-thickness skin explants with low or undetectable levels in CM of splenic and bone marrow cell suspensions. In irradiated mice (2 Gy, X rays) on day 3 post exposure a significant increase of IL-1 levels was seen in the circulation and CM of peritoneal exudate cells, with no significantly different levels in postirradiation bone marrow, spleen and skin. After rhIL-1Ra treatment of the animals (2 x 50 mu g/mouse, i.p.), significantly elevated IL-1 levels were observed in the skin and CM of peritoneal exudate cells in normal mice, whereas slightly increased levels were detected in CM of splenic cells. The rhIL-1Ra administration in irradiated mice led to decreased IL-1 concentrations in the circulation, and CM of peritoneal exudate cells and skin. The results pointed out the importance of IL-1 secretion and receptor expression in the maintenance of homeostasis in steady state, as well as during recovery after irradiation. Modulatory effects of IL-1Ra on IL-1 production were dependent on basic endogenous IL-1 concentration. | en |
dc.publisher | Acad Sciences Czech Republic, Inst Physiology, Prague 4 | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Physiological Research | |
dc.subject | rhIL-1Ra | en |
dc.subject | IL-1 | en |
dc.subject | in vivo | en |
dc.subject | steady-state | en |
dc.subject | irradiation | en |
dc.title | Effects of treatment with interleukin-1 receptor antagonist on endogenous interleukin-1 levels in normal and irradiated mice | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dc.citation.epage | 362 | |
dc.citation.issue | 3 | |
dc.citation.other | 49(3): 355-362 | |
dc.citation.rank | M22 | |
dc.citation.spage | 355 | |
dc.citation.volume | 49 | |
dc.identifier.pmid | 11043923 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_rimi_61 | |
dc.identifier.wos | 000088843100009 | |
dc.type.version | publishedVersion |
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