Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease

Abstract

Beyond being central players in haemostasis and thrombosis, platelets have crucial roles in the development of atherosclerosis, mediated through their interactions with monocytes and endothelial cells. Disturbed platelet function correlates with other risk factors and the progression of CVD, postulating platelets as rational targets in CVD prevention. The effects of polyphenols on platelets have been studied in numerous pre-clinical and clinical trials, and the data reported from these studies support the hypothesis that modulation of platelet function contributes significantly to pleiotropic beneficial effects of polyphenols on cardiovascular health. To provide comprehensive scientific evidence for the promotion of polyphenols as antiplatelet agents, further studies should address the influence of polyphenol metabolism on the observed effects, identify active polyphenols/metabolites and elucidate the precise mechanisms of their action.