Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease
Abstract
Beyond being central players in haemostasis and thrombosis, platelets have crucial roles in the development of atherosclerosis, mediated through their interactions with monocytes and endothelial cells. Disturbed platelet function correlates with other risk factors and the progression of CVD, postulating platelets as rational targets in CVD prevention. The effects of polyphenols on platelets have been studied in numerous pre-clinical and clinical trials, and the data reported from these studies support the hypothesis that modulation of platelet function contributes significantly to pleiotropic beneficial effects of polyphenols on cardiovascular health. To provide comprehensive scientific evidence for the promotion of polyphenols as antiplatelet agents, further studies should address the influence of polyphenol metabolism on the observed effects, identify active polyphenols/metabolites and elucidate the precise mechanisms of their action.
Keywords:
Platelets / polyphenols / cardiovascular disease / atherosclerosis / monocytes / flow cytometrySource:
Agro Food Industry Hi-Tech, 2015, 26, 2, 15-18Publisher:
- Teknoscienze Publ, Milano
Funding / projects:
- Beneficial effects of dietary bioactive peptides and polyphenols on cardiovascular health in humans (EU-FP7-312090)
- UK Research & Innovation (UKRI) Biotechnology and Biological Sciences Research Council (BBSRC) [BBS/E/F/00044434, BBS/E/F/00042675]
Collections
Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Konić-Ristić, Aleksandra AU - Kroon, Paul A. AU - Glibetić, Marija PY - 2015 UR - http://rimi.imi.bg.ac.rs/handle/123456789/614 AB - Beyond being central players in haemostasis and thrombosis, platelets have crucial roles in the development of atherosclerosis, mediated through their interactions with monocytes and endothelial cells. Disturbed platelet function correlates with other risk factors and the progression of CVD, postulating platelets as rational targets in CVD prevention. The effects of polyphenols on platelets have been studied in numerous pre-clinical and clinical trials, and the data reported from these studies support the hypothesis that modulation of platelet function contributes significantly to pleiotropic beneficial effects of polyphenols on cardiovascular health. To provide comprehensive scientific evidence for the promotion of polyphenols as antiplatelet agents, further studies should address the influence of polyphenol metabolism on the observed effects, identify active polyphenols/metabolites and elucidate the precise mechanisms of their action. PB - Teknoscienze Publ, Milano T2 - Agro Food Industry Hi-Tech T1 - Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease EP - 18 IS - 2 SP - 15 VL - 26 UR - https://hdl.handle.net/21.15107/rcub_rimi_614 ER -
@article{ author = "Konić-Ristić, Aleksandra and Kroon, Paul A. and Glibetić, Marija", year = "2015", abstract = "Beyond being central players in haemostasis and thrombosis, platelets have crucial roles in the development of atherosclerosis, mediated through their interactions with monocytes and endothelial cells. Disturbed platelet function correlates with other risk factors and the progression of CVD, postulating platelets as rational targets in CVD prevention. The effects of polyphenols on platelets have been studied in numerous pre-clinical and clinical trials, and the data reported from these studies support the hypothesis that modulation of platelet function contributes significantly to pleiotropic beneficial effects of polyphenols on cardiovascular health. To provide comprehensive scientific evidence for the promotion of polyphenols as antiplatelet agents, further studies should address the influence of polyphenol metabolism on the observed effects, identify active polyphenols/metabolites and elucidate the precise mechanisms of their action.", publisher = "Teknoscienze Publ, Milano", journal = "Agro Food Industry Hi-Tech", title = "Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease", pages = "18-15", number = "2", volume = "26", url = "https://hdl.handle.net/21.15107/rcub_rimi_614" }
Konić-Ristić, A., Kroon, P. A.,& Glibetić, M.. (2015). Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease. in Agro Food Industry Hi-Tech Teknoscienze Publ, Milano., 26(2), 15-18. https://hdl.handle.net/21.15107/rcub_rimi_614
Konić-Ristić A, Kroon PA, Glibetić M. Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease. in Agro Food Industry Hi-Tech. 2015;26(2):15-18. https://hdl.handle.net/21.15107/rcub_rimi_614 .
Konić-Ristić, Aleksandra, Kroon, Paul A., Glibetić, Marija, "Modulation of platelet function with dietary polyphenols A promising strategy in the prevention of cardiovascular disease" in Agro Food Industry Hi-Tech, 26, no. 2 (2015):15-18, https://hdl.handle.net/21.15107/rcub_rimi_614 .