Cholesterol: Absorption, Function and Metabolism

Abstract

Cholesterol is a vital component of animal plasma membranes and of the other cellular organelles. It regulates membrane integrity, fluidity, and permeability. Furthermore, cholesterol is a precursor for steroid hormones, bile acids, and vitamin D. Several classes of lipoproteins are involved in the transport of cholesterol between the liver and the peripheral tissues. Concentration of plasma cholesterol depends not only on endogenous biosynthesis but also on dietary intake. In spite of its vital function, high levels of blood cholesterol have been well-established risk factors for cardiovascular disease. To prevent atherosclerosis and development of cardiovascular disease, many medications are available nowadays to control levels of blood cholesterol.