The aim of our study was to investigate the appearance, density and distribution of ghrelin cells and GHS-R1a and GHS-R1b in the human stomach and duodenum during prenatal and early postnatal development. We examined chromogranin-A and ghrelin cells in duodenum, and GHS-R1a and GHS-R1b expressionin stomach and duodenum by immunohistochemistry in embryos, fetuses, and infants. Chromogranin-A and ghrelin cells were identified in the duodenum at weeks 10 and 11 of gestation. Ghrelin cells were detected individually or clustered within the base of duodenal crypts and villi during the first trimester, while they were presented separately within the basal and apical parts of crypts and villi during the second and third trimesters. Ghrelin cells were the most numerous during the first (similar to 11%) and third(similar to 10%) trimesters of gestation development. GHS-R1a and GHS-R1b were detected at 11 and 16 weeks of gestation, showed the highest level of expression in Brunner's gland and in... lower parts of duodenal crypts and villi during the second trimester in antrum, and during the third trimester in corpus and duodenum. Our findings demonstrated for the first time abundant duodenal expression of ghrelin cells and ghrelin receptors during human prenatal development indicating a role of ghrelin in the regulation of growth and differentiation of human gastrointestinal tract.
Keywords:
Human fetal duodenum / GHSR1a and GHS-R1b / Appearance / Distribution and density of ghrelin cells
TY - JOUR
AU - Mitrović, Olivera
AU - Čokić, Vladan
AU - Đikić, Dragoslava
AU - Budeč, Mirela
AU - Vignjević, Sanja
AU - Subotički, Tijana
AU - Diklić, Miloš
AU - Ajtić, Rastko
PY - 2014
UR - http://rimi.imi.bg.ac.rs/handle/123456789/600
AB - The aim of our study was to investigate the appearance, density and distribution of ghrelin cells and GHS-R1a and GHS-R1b in the human stomach and duodenum during prenatal and early postnatal development. We examined chromogranin-A and ghrelin cells in duodenum, and GHS-R1a and GHS-R1b expressionin stomach and duodenum by immunohistochemistry in embryos, fetuses, and infants. Chromogranin-A and ghrelin cells were identified in the duodenum at weeks 10 and 11 of gestation. Ghrelin cells were detected individually or clustered within the base of duodenal crypts and villi during the first trimester, while they were presented separately within the basal and apical parts of crypts and villi during the second and third trimesters. Ghrelin cells were the most numerous during the first (similar to 11%) and third(similar to 10%) trimesters of gestation development. GHS-R1a and GHS-R1b were detected at 11 and 16 weeks of gestation, showed the highest level of expression in Brunner's gland and in lower parts of duodenal crypts and villi during the second trimester in antrum, and during the third trimester in corpus and duodenum. Our findings demonstrated for the first time abundant duodenal expression of ghrelin cells and ghrelin receptors during human prenatal development indicating a role of ghrelin in the regulation of growth and differentiation of human gastrointestinal tract.
PB - Elsevier Science Inc, New York
T2 - Peptides
T1 - Ghrelin receptors in human gastrointestinal tract during prenatal and early postnatal development
EP - 11
SP - 1
VL - 57
DO - 10.1016/j.peptides.2014.04.010
UR - conv_3277
ER -
@article{
author = "Mitrović, Olivera and Čokić, Vladan and Đikić, Dragoslava and Budeč, Mirela and Vignjević, Sanja and Subotički, Tijana and Diklić, Miloš and Ajtić, Rastko",
year = "2014",
abstract = "The aim of our study was to investigate the appearance, density and distribution of ghrelin cells and GHS-R1a and GHS-R1b in the human stomach and duodenum during prenatal and early postnatal development. We examined chromogranin-A and ghrelin cells in duodenum, and GHS-R1a and GHS-R1b expressionin stomach and duodenum by immunohistochemistry in embryos, fetuses, and infants. Chromogranin-A and ghrelin cells were identified in the duodenum at weeks 10 and 11 of gestation. Ghrelin cells were detected individually or clustered within the base of duodenal crypts and villi during the first trimester, while they were presented separately within the basal and apical parts of crypts and villi during the second and third trimesters. Ghrelin cells were the most numerous during the first (similar to 11%) and third(similar to 10%) trimesters of gestation development. GHS-R1a and GHS-R1b were detected at 11 and 16 weeks of gestation, showed the highest level of expression in Brunner's gland and in lower parts of duodenal crypts and villi during the second trimester in antrum, and during the third trimester in corpus and duodenum. Our findings demonstrated for the first time abundant duodenal expression of ghrelin cells and ghrelin receptors during human prenatal development indicating a role of ghrelin in the regulation of growth and differentiation of human gastrointestinal tract.",
publisher = "Elsevier Science Inc, New York",
journal = "Peptides",
title = "Ghrelin receptors in human gastrointestinal tract during prenatal and early postnatal development",
pages = "11-1",
volume = "57",
doi = "10.1016/j.peptides.2014.04.010",
url = "conv_3277"
}
Mitrović, O., Čokić, V., Đikić, D., Budeč, M., Vignjević, S., Subotički, T., Diklić, M.,& Ajtić, R.. (2014). Ghrelin receptors in human gastrointestinal tract during prenatal and early postnatal development. in Peptides
Elsevier Science Inc, New York., 57, 1-11.
https://doi.org/10.1016/j.peptides.2014.04.010
conv_3277
Mitrović O, Čokić V, Đikić D, Budeč M, Vignjević S, Subotički T, Diklić M, Ajtić R. Ghrelin receptors in human gastrointestinal tract during prenatal and early postnatal development. in Peptides. 2014;57:1-11.
doi:10.1016/j.peptides.2014.04.010
conv_3277 .
Mitrović, Olivera, Čokić, Vladan, Đikić, Dragoslava, Budeč, Mirela, Vignjević, Sanja, Subotički, Tijana, Diklić, Miloš, Ajtić, Rastko, "Ghrelin receptors in human gastrointestinal tract during prenatal and early postnatal development" in Peptides, 57 (2014):1-11,
https://doi.org/10.1016/j.peptides.2014.04.010 .,
conv_3277 .
