Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis
Само за регистроване кориснике
2021
Аутори
Karanović, Danijela
Mihailović-Stanojević, Nevena

Miloradović, Zoran

Ivanov, Milan

Vajić, Una-Jovana

Grujić-Milanović, Jelica

Marković-Lipkovski, Jasmina

Dekanski, Dragana

Jovović, Đurđica
Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
Olive (Olea europaea L.) leaf extract (OLE) possesses powerful antioxidant, antihyperlipidemic, and anti-inflammatory properties. The aim was to investigated the effects of OLE on the hyperlipidemia, antioxidant defense, heme oxygenase/biliverdin reductase (HO/BVR) pathway, inflammation, and fibrosis in spontaneously hypertensive rats with focal segmental glomerulosclerosis (FSGS, a progressive form of chronic kidney disease) induced by adriamycin (2 mg/kg, i.v., twice in a 21-day period). Daily treatment of OLE (80 mg/kg, p.o.) for 6 weeks suppressed protein oxidation and lipid peroxidation (p lt .01 and p lt .001, respectively), significantly increased antioxidant enzymes activities and normalized antioxidant capacity, leading to the improvement of antioxidant defense independently of the HO/BVR pathway. Furthermore, the values of triglycerides (p lt .01), total, and low-density lipoprotein cholesterol (p lt .05, both) were improved by OLE. OLE strongly prevented glomeruloscl...erosis, interstitial inflammation, and fibrosis (renal injury score, FSGS: 8 +/- 0.45 vs. FSGS+OLE: 4.20 +/- 1.07; p lt .01), as evidenced by normalized fibronectin content (p lt .001), suppressed interstitial inflammatory cells infiltration and collagen deposition, without changing cytokines expressions. OLE decreased blood pressure with a tendency to reduce urine albumin loss. These data suggest that OLE may be effective in slowing down the progression of FSGS.
Кључне речи:
adriamycin nephropathy / fibronectin / hyperlipidemia / hypertension / olive leaf / oxidative stressИзвор:
Phytotherapy Research, 2021, 35, 3, 1534-1545Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
DOI: 10.1002/ptr.6920
ISSN: 0951-418X
PubMed: 33098170
WoS: 000581577200001
Scopus: 2-s2.0-85093499173
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Karanović, Danijela AU - Mihailović-Stanojević, Nevena AU - Miloradović, Zoran AU - Ivanov, Milan AU - Vajić, Una-Jovana AU - Grujić-Milanović, Jelica AU - Marković-Lipkovski, Jasmina AU - Dekanski, Dragana AU - Jovović, Đurđica PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/5 AB - Olive (Olea europaea L.) leaf extract (OLE) possesses powerful antioxidant, antihyperlipidemic, and anti-inflammatory properties. The aim was to investigated the effects of OLE on the hyperlipidemia, antioxidant defense, heme oxygenase/biliverdin reductase (HO/BVR) pathway, inflammation, and fibrosis in spontaneously hypertensive rats with focal segmental glomerulosclerosis (FSGS, a progressive form of chronic kidney disease) induced by adriamycin (2 mg/kg, i.v., twice in a 21-day period). Daily treatment of OLE (80 mg/kg, p.o.) for 6 weeks suppressed protein oxidation and lipid peroxidation (p lt .01 and p lt .001, respectively), significantly increased antioxidant enzymes activities and normalized antioxidant capacity, leading to the improvement of antioxidant defense independently of the HO/BVR pathway. Furthermore, the values of triglycerides (p lt .01), total, and low-density lipoprotein cholesterol (p lt .05, both) were improved by OLE. OLE strongly prevented glomerulosclerosis, interstitial inflammation, and fibrosis (renal injury score, FSGS: 8 +/- 0.45 vs. FSGS+OLE: 4.20 +/- 1.07; p lt .01), as evidenced by normalized fibronectin content (p lt .001), suppressed interstitial inflammatory cells infiltration and collagen deposition, without changing cytokines expressions. OLE decreased blood pressure with a tendency to reduce urine albumin loss. These data suggest that OLE may be effective in slowing down the progression of FSGS. PB - Wiley, Hoboken T2 - Phytotherapy Research T1 - Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis EP - 1545 IS - 3 SP - 1534 VL - 35 DO - 10.1002/ptr.6920 ER -
@article{ author = "Karanović, Danijela and Mihailović-Stanojević, Nevena and Miloradović, Zoran and Ivanov, Milan and Vajić, Una-Jovana and Grujić-Milanović, Jelica and Marković-Lipkovski, Jasmina and Dekanski, Dragana and Jovović, Đurđica", year = "2021", abstract = "Olive (Olea europaea L.) leaf extract (OLE) possesses powerful antioxidant, antihyperlipidemic, and anti-inflammatory properties. The aim was to investigated the effects of OLE on the hyperlipidemia, antioxidant defense, heme oxygenase/biliverdin reductase (HO/BVR) pathway, inflammation, and fibrosis in spontaneously hypertensive rats with focal segmental glomerulosclerosis (FSGS, a progressive form of chronic kidney disease) induced by adriamycin (2 mg/kg, i.v., twice in a 21-day period). Daily treatment of OLE (80 mg/kg, p.o.) for 6 weeks suppressed protein oxidation and lipid peroxidation (p lt .01 and p lt .001, respectively), significantly increased antioxidant enzymes activities and normalized antioxidant capacity, leading to the improvement of antioxidant defense independently of the HO/BVR pathway. Furthermore, the values of triglycerides (p lt .01), total, and low-density lipoprotein cholesterol (p lt .05, both) were improved by OLE. OLE strongly prevented glomerulosclerosis, interstitial inflammation, and fibrosis (renal injury score, FSGS: 8 +/- 0.45 vs. FSGS+OLE: 4.20 +/- 1.07; p lt .01), as evidenced by normalized fibronectin content (p lt .001), suppressed interstitial inflammatory cells infiltration and collagen deposition, without changing cytokines expressions. OLE decreased blood pressure with a tendency to reduce urine albumin loss. These data suggest that OLE may be effective in slowing down the progression of FSGS.", publisher = "Wiley, Hoboken", journal = "Phytotherapy Research", title = "Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis", pages = "1545-1534", number = "3", volume = "35", doi = "10.1002/ptr.6920" }
Karanović, D., Mihailović-Stanojević, N., Miloradović, Z., Ivanov, M., Vajić, U., Grujić-Milanović, J., Marković-Lipkovski, J., Dekanski, D.,& Jovović, Đ.. (2021). Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis. in Phytotherapy Research Wiley, Hoboken., 35(3), 1534-1545. https://doi.org/10.1002/ptr.6920
Karanović D, Mihailović-Stanojević N, Miloradović Z, Ivanov M, Vajić U, Grujić-Milanović J, Marković-Lipkovski J, Dekanski D, Jovović Đ. Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis. in Phytotherapy Research. 2021;35(3):1534-1545. doi:10.1002/ptr.6920 .
Karanović, Danijela, Mihailović-Stanojević, Nevena, Miloradović, Zoran, Ivanov, Milan, Vajić, Una-Jovana, Grujić-Milanović, Jelica, Marković-Lipkovski, Jasmina, Dekanski, Dragana, Jovović, Đurđica, "Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis" in Phytotherapy Research, 35, no. 3 (2021):1534-1545, https://doi.org/10.1002/ptr.6920 . .