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dc.creatorOkić Đorđević, Ivana
dc.creatorTrivanović, Drenka
dc.creatorJovanović, Miloš
dc.creatorIgnjatović, Marija
dc.creatorSecerov, Bojana
dc.creatorMojović, Miloš
dc.creatorBugarski, Diana
dc.creatorBacić, Goran
dc.creatorAnđus, Pavle R.
dc.date.accessioned2021-04-20T12:40:33Z
dc.date.available2021-04-20T12:40:33Z
dc.date.issued2014
dc.identifier.issn0353-9504
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/592
dc.description.abstractAim To investigate the survival of laboratory rats after irradiation and to study the cellularity of their bone marrow and the multipotential mesenchymal stem cells (BM-MSCs) in groups treated with or without a new thiol-based radioprotector (GM2011) Methods Animals were irradiated by a Cobalt gamma source at 6.7 Gy. Treated animals were given i.p. GM2011 30 minutes before and 3 and 7 hours after irradiation. Controls consisted of sham irradiated animals without treatment and animals treated without irradiation. After 30 days post-irradiation, animals were sacrificed and bone marrow cells were prepared from isolated femurs. A colony forming unit-fibroblast (CFU-F) assay was performed to obtain the number of BM-MSCs. Results In the treated group, 87% of animals survived, compared to only 30% in the non-treated irradiated group. Irradiation induced significant changes in the bone marrow of the treated rats (total bone marrow cellularity was reduced by similar to 60% - from 63 to 28 cells x10(6)/femur and the frequency of the CFU-F per femur by similar to 70% - from 357 to 97), however GL2011 almost completely prevented the suppressive effect observed on day 30 post-irradiation (71 cells x 10(6)/femur and 230 CFU-F/femur). Conclusion Although the irradiation dosage was relatively high, GL2011 acted as a very effective new radioprotector. The recovery of the BN-MSCs and their counts support the effectiveness of the studied radioprotector.en
dc.publisherMedicinska Naklada, Zagreb
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41005/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceCroatian Medical Journal
dc.titleIncreased survival after irradiation followed by regeneration of bone marrow stromal cells with a novel thiol-based radioprotectoren
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage49
dc.citation.issue1
dc.citation.other55(1): 45-49
dc.citation.rankM22
dc.citation.spage45
dc.citation.volume55
dc.identifier.doi10.3325/cmj.2014.55.45
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/453/589.pdf
dc.identifier.pmid24577826
dc.identifier.scopus2-s2.0-84895791458
dc.identifier.wos000333666400008
dc.type.versionpublishedVersion


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