Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries
2014
Autori
Petrović, SnježanaTakić, Marija
Arsić, Aleksandra
Vučić, Vesna M.
Drakulić, Dunja
Milošević, Maja
Glibetić, Marija
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The effects of 8-days treatment with 17 alpha-estradiol (33.3 mu g/kg) and progesterone (1.7 mg/kg) on plasma lipids and fatty acid composition of plasma phospholipids were examined in intact (INT) and bilaterally common carotid arteries occluded (BCO) male Wistar rats. Significant decrease of triglyceride level was found in BCO rats after the estradiol treatment. Both hormones elevated proportion of 18:1n-7 fatty acid in INT, but they failed to have such an effect in BCO. Estradiol increased 22:5n-3 and total n-3 polyunsaturated fatty acids (PUFA) in intact, and decreased 18:2n-6 in BCO rats. Significantly lower level of total n-3 was found in progesterone-treated than in estradiol-treated BCO rats. Given that n-3 PUFA have many beneficial effects on cell and tissue function, while n-6 PUFA have mostly the opposite effects, estradiol, rather than progesterone, was seen to improve plasma lipids and phospholipids FA profiles in INT and BCO animals. Estradiol significantly elevated the e...stimated activity of Delta 9-desaturases and progesterone of Delta 5-desaturase in BCO group, with no effects in INT rats.
Ključne reči:
Estradiol / Progesterone / Male rats / Plasma lipids / Fatty acidsIzvor:
Physiological Research, 2014, 63, 3, 331-339Izdavač:
- Acad Sciences Czech Republic, Inst Physiology, Prague 4
Finansiranje / projekti:
- Biološki mehanizmi, nutritivni unos i status polinezasićenih masnih kiselina i folata: Unapređenje ishrane u Srbiji (RS-41030)
- Molekularni mehanizmi patofizioloških promena u ćelijama centralnog nervnog sistema i perifernog tkiva kod sisara (RS-173044)
DOI: 10.33549/physiolres.932590
ISSN: 0862-8408
PubMed: 24564600
WoS: 000339879900006
[ Google Scholar ]Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Petrović, Snježana AU - Takić, Marija AU - Arsić, Aleksandra AU - Vučić, Vesna M. AU - Drakulić, Dunja AU - Milošević, Maja AU - Glibetić, Marija PY - 2014 UR - http://rimi.imi.bg.ac.rs/handle/123456789/572 AB - The effects of 8-days treatment with 17 alpha-estradiol (33.3 mu g/kg) and progesterone (1.7 mg/kg) on plasma lipids and fatty acid composition of plasma phospholipids were examined in intact (INT) and bilaterally common carotid arteries occluded (BCO) male Wistar rats. Significant decrease of triglyceride level was found in BCO rats after the estradiol treatment. Both hormones elevated proportion of 18:1n-7 fatty acid in INT, but they failed to have such an effect in BCO. Estradiol increased 22:5n-3 and total n-3 polyunsaturated fatty acids (PUFA) in intact, and decreased 18:2n-6 in BCO rats. Significantly lower level of total n-3 was found in progesterone-treated than in estradiol-treated BCO rats. Given that n-3 PUFA have many beneficial effects on cell and tissue function, while n-6 PUFA have mostly the opposite effects, estradiol, rather than progesterone, was seen to improve plasma lipids and phospholipids FA profiles in INT and BCO animals. Estradiol significantly elevated the estimated activity of Delta 9-desaturases and progesterone of Delta 5-desaturase in BCO group, with no effects in INT rats. PB - Acad Sciences Czech Republic, Inst Physiology, Prague 4 T2 - Physiological Research T1 - Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries EP - 339 IS - 3 SP - 331 VL - 63 DO - 10.33549/physiolres.932590 ER -
@article{ author = "Petrović, Snježana and Takić, Marija and Arsić, Aleksandra and Vučić, Vesna M. and Drakulić, Dunja and Milošević, Maja and Glibetić, Marija", year = "2014", abstract = "The effects of 8-days treatment with 17 alpha-estradiol (33.3 mu g/kg) and progesterone (1.7 mg/kg) on plasma lipids and fatty acid composition of plasma phospholipids were examined in intact (INT) and bilaterally common carotid arteries occluded (BCO) male Wistar rats. Significant decrease of triglyceride level was found in BCO rats after the estradiol treatment. Both hormones elevated proportion of 18:1n-7 fatty acid in INT, but they failed to have such an effect in BCO. Estradiol increased 22:5n-3 and total n-3 polyunsaturated fatty acids (PUFA) in intact, and decreased 18:2n-6 in BCO rats. Significantly lower level of total n-3 was found in progesterone-treated than in estradiol-treated BCO rats. Given that n-3 PUFA have many beneficial effects on cell and tissue function, while n-6 PUFA have mostly the opposite effects, estradiol, rather than progesterone, was seen to improve plasma lipids and phospholipids FA profiles in INT and BCO animals. Estradiol significantly elevated the estimated activity of Delta 9-desaturases and progesterone of Delta 5-desaturase in BCO group, with no effects in INT rats.", publisher = "Acad Sciences Czech Republic, Inst Physiology, Prague 4", journal = "Physiological Research", title = "Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries", pages = "339-331", number = "3", volume = "63", doi = "10.33549/physiolres.932590" }
Petrović, S., Takić, M., Arsić, A., Vučić, V. M., Drakulić, D., Milošević, M.,& Glibetić, M.. (2014). Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries. in Physiological Research Acad Sciences Czech Republic, Inst Physiology, Prague 4., 63(3), 331-339. https://doi.org/10.33549/physiolres.932590
Petrović S, Takić M, Arsić A, Vučić VM, Drakulić D, Milošević M, Glibetić M. Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries. in Physiological Research. 2014;63(3):331-339. doi:10.33549/physiolres.932590 .
Petrović, Snježana, Takić, Marija, Arsić, Aleksandra, Vučić, Vesna M., Drakulić, Dunja, Milošević, Maja, Glibetić, Marija, "Effect of Sex Hormones on Plasma Phospholipid Fatty Acid Composition in Intact Rats and Rats With Bilaterally Occluded Carotid Arteries" in Physiological Research, 63, no. 3 (2014):331-339, https://doi.org/10.33549/physiolres.932590 . .