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The Effect of Paraprotein on Platelet Aggregation

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2014
563.pdf (361.2Kb)
Authors
Đunić, Irena
Elezović, Ivo
Ilić, Vesna
Milošević-Jovčić, Nadežda
Bila, Jelena
Suvajdžić-Vuković, Nada
Antić, Darko
Vidović, Ana
Tomin, Dragica
Article (Published version)
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Abstract
Background Some patients with paraproteinemia have platelet aggregation disorders and the aim of this study was to examine disturbance of platelet aggregation in healthy blood donors by isolated paraprotein in vitro. Methods Using Rivanol, paraprotein was separated from the serum of ten patients with paraproteinemia, who had decreased platelet aggregation with several inducers. Platelet aggregation in ten healthy donors was measured with and without addition of the isolated induced paraprotein. The test was repeated with added human immunoglobulins for intravenous use. Results Average of maximal levels of platelet aggregation has been significantly decreased in plasma rich in platelets (PRP) of healthy donors after addition of paraprotein when inducers are used: adenosine diphosphate (ADP) (P = 0.007), collagen (COL) (P = 0.008), ristocetin (RIS) (P = 0.001), and epinephrine (EPI) (P = 0.002). Average of latent time of platelet aggregation was significantly prolonged in healthy donors ...after addition of paraprotein with inducers: COL (P = 0.008), RIS (P = 0.008) and EPI (P = 0.006) while addition of human immunoglobulins caused no change in platelet aggregation. In comparison, when human immunoglobulins were added, maximal platelet aggregation and latent time did not change significantly. Paraprotein isolated from patients with paraproteinamia, who had decrease platelet aggregation, had significantly decreased platelet aggregation when added to PRP of healthy donors, in vitro. Conclusion Platelet aggregation was not significantly changed was confirmed with addition of human immunoglobulins.

Keywords:
paraproteinemia / role of paraprotein / platelet aggregation
Source:
Journal of Clinical Laboratory Analysis, 2014, 28, 2, 141-146
Publisher:
  • John Wiley & Sons Inc, Hoboken

DOI: 10.1002/jcla.21658

ISSN: 0887-8013

PubMed: 24395751

WoS: 000332840500011

Scopus: 2-s2.0-84896120163
[ Google Scholar ]
6
3
URI
http://rimi.imi.bg.ac.rs/handle/123456789/566
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Đunić, Irena
AU  - Elezović, Ivo
AU  - Ilić, Vesna
AU  - Milošević-Jovčić, Nadežda
AU  - Bila, Jelena
AU  - Suvajdžić-Vuković, Nada
AU  - Antić, Darko
AU  - Vidović, Ana
AU  - Tomin, Dragica
PY  - 2014
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/566
AB  - Background Some patients with paraproteinemia have platelet aggregation disorders and the aim of this study was to examine disturbance of platelet aggregation in healthy blood donors by isolated paraprotein in vitro. Methods Using Rivanol, paraprotein was separated from the serum of ten patients with paraproteinemia, who had decreased platelet aggregation with several inducers. Platelet aggregation in ten healthy donors was measured with and without addition of the isolated induced paraprotein. The test was repeated with added human immunoglobulins for intravenous use. Results Average of maximal levels of platelet aggregation has been significantly decreased in plasma rich in platelets (PRP) of healthy donors after addition of paraprotein when inducers are used: adenosine diphosphate (ADP) (P = 0.007), collagen (COL) (P = 0.008), ristocetin (RIS) (P = 0.001), and epinephrine (EPI) (P = 0.002). Average of latent time of platelet aggregation was significantly prolonged in healthy donors after addition of paraprotein with inducers: COL (P = 0.008), RIS (P = 0.008) and EPI (P = 0.006) while addition of human immunoglobulins caused no change in platelet aggregation. In comparison, when human immunoglobulins were added, maximal platelet aggregation and latent time did not change significantly. Paraprotein isolated from patients with paraproteinamia, who had decrease platelet aggregation, had significantly decreased platelet aggregation when added to PRP of healthy donors, in vitro. Conclusion Platelet aggregation was not significantly changed was confirmed with addition of human immunoglobulins.
PB  - John Wiley & Sons Inc, Hoboken
T2  - Journal of Clinical Laboratory Analysis
T1  - The Effect of Paraprotein on Platelet Aggregation
EP  - 146
IS  - 2
SP  - 141
VL  - 28
DO  - 10.1002/jcla.21658
UR  - conv_3196
ER  - 
@article{
author = "Đunić, Irena and Elezović, Ivo and Ilić, Vesna and Milošević-Jovčić, Nadežda and Bila, Jelena and Suvajdžić-Vuković, Nada and Antić, Darko and Vidović, Ana and Tomin, Dragica",
year = "2014",
abstract = "Background Some patients with paraproteinemia have platelet aggregation disorders and the aim of this study was to examine disturbance of platelet aggregation in healthy blood donors by isolated paraprotein in vitro. Methods Using Rivanol, paraprotein was separated from the serum of ten patients with paraproteinemia, who had decreased platelet aggregation with several inducers. Platelet aggregation in ten healthy donors was measured with and without addition of the isolated induced paraprotein. The test was repeated with added human immunoglobulins for intravenous use. Results Average of maximal levels of platelet aggregation has been significantly decreased in plasma rich in platelets (PRP) of healthy donors after addition of paraprotein when inducers are used: adenosine diphosphate (ADP) (P = 0.007), collagen (COL) (P = 0.008), ristocetin (RIS) (P = 0.001), and epinephrine (EPI) (P = 0.002). Average of latent time of platelet aggregation was significantly prolonged in healthy donors after addition of paraprotein with inducers: COL (P = 0.008), RIS (P = 0.008) and EPI (P = 0.006) while addition of human immunoglobulins caused no change in platelet aggregation. In comparison, when human immunoglobulins were added, maximal platelet aggregation and latent time did not change significantly. Paraprotein isolated from patients with paraproteinamia, who had decrease platelet aggregation, had significantly decreased platelet aggregation when added to PRP of healthy donors, in vitro. Conclusion Platelet aggregation was not significantly changed was confirmed with addition of human immunoglobulins.",
publisher = "John Wiley & Sons Inc, Hoboken",
journal = "Journal of Clinical Laboratory Analysis",
title = "The Effect of Paraprotein on Platelet Aggregation",
pages = "146-141",
number = "2",
volume = "28",
doi = "10.1002/jcla.21658",
url = "conv_3196"
}
Đunić, I., Elezović, I., Ilić, V., Milošević-Jovčić, N., Bila, J., Suvajdžić-Vuković, N., Antić, D., Vidović, A.,& Tomin, D.. (2014). The Effect of Paraprotein on Platelet Aggregation. in Journal of Clinical Laboratory Analysis
John Wiley & Sons Inc, Hoboken., 28(2), 141-146.
https://doi.org/10.1002/jcla.21658
conv_3196
Đunić I, Elezović I, Ilić V, Milošević-Jovčić N, Bila J, Suvajdžić-Vuković N, Antić D, Vidović A, Tomin D. The Effect of Paraprotein on Platelet Aggregation. in Journal of Clinical Laboratory Analysis. 2014;28(2):141-146.
doi:10.1002/jcla.21658
conv_3196 .
Đunić, Irena, Elezović, Ivo, Ilić, Vesna, Milošević-Jovčić, Nadežda, Bila, Jelena, Suvajdžić-Vuković, Nada, Antić, Darko, Vidović, Ana, Tomin, Dragica, "The Effect of Paraprotein on Platelet Aggregation" in Journal of Clinical Laboratory Analysis, 28, no. 2 (2014):141-146,
https://doi.org/10.1002/jcla.21658 .,
conv_3196 .

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