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Effects of high dose olive leaf extract on the hemodynamic and oxidative stress parameters in normotensive and spontaneously hypertensive rats

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2014
549.pdf (417.7Kb)
Authors
Dekanski, Dragana
Mihailović-Stanojević, Nevena
Grujić-Milanović, Jelica
Jovović, Đurđica
Miloradović, Zoran
Article (Published version)
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Abstract
The antihypertensive activity of olive leaf extract (OLE), a natural antioxidant is recognized, but its influence on the cardiovascular system when administered in a high dose has not yet been investigated. The aim of the present study was to determine the acute effects of excessive intake of standardized OLE on blood pressure, heart rate and oxidative status in both spontaneously hypertensive rats and normotensive Wistar rats. The systolic arterial pressure and heart rate were measured using a tail-cuff and pneumatic pulse detector before and 60 and 120 min after intragastric OLE administration. The activities of catalase, glutathione peroxidase, superoxide dismutase (SOD) and glutathione reductase in erythrocytes, as well as lipid peroxidation in plasma (pTBARS) were measured spectrophotometrically at the same time points. A high-dose of OLE did not influence blood pressure, heart rate or pTBARS in normotensive rats, while the SOD, catalase and glutathione reductase activities were s...ignificantly increased. The same dose significantly decreased blood pressure in hypertensive rats, but increased the pTBARS and SOD activity. Excessive oral intake of OLE induced moderate hypotensive effects only in spontaneously hypertensive rats, suggesting the absence of harmful hemodynamic effects after an oral overdose in both rat strains. However, its pro-oxidative role when given in a high dose in hypertensive organisms should not be neglected.

Keywords:
Olea europaea L. / hypertension / acute oral toxicity / spontaneously hypertensive rat / oxidative stress
Source:
Journal of the Serbian Chemical Society, 2014, 79, 9, 1085-1097
Publisher:
  • Srpsko hemijsko društvo, Beograd
Funding / projects:
  • Investigation of antihypertensiv? and renoprotectiv? potential of natural and synthetic compounds in the experimental models of cardiovascular and renal diseases (RS-175096)

DOI: 10.2298/JSC140218030D

ISSN: 0352-5139

WoS: 000342524500004

Scopus: 2-s2.0-84918544417
[ Google Scholar ]
11
8
URI
http://rimi.imi.bg.ac.rs/handle/123456789/552
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Dekanski, Dragana
AU  - Mihailović-Stanojević, Nevena
AU  - Grujić-Milanović, Jelica
AU  - Jovović, Đurđica
AU  - Miloradović, Zoran
PY  - 2014
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/552
AB  - The antihypertensive activity of olive leaf extract (OLE), a natural antioxidant is recognized, but its influence on the cardiovascular system when administered in a high dose has not yet been investigated. The aim of the present study was to determine the acute effects of excessive intake of standardized OLE on blood pressure, heart rate and oxidative status in both spontaneously hypertensive rats and normotensive Wistar rats. The systolic arterial pressure and heart rate were measured using a tail-cuff and pneumatic pulse detector before and 60 and 120 min after intragastric OLE administration. The activities of catalase, glutathione peroxidase, superoxide dismutase (SOD) and glutathione reductase in erythrocytes, as well as lipid peroxidation in plasma (pTBARS) were measured spectrophotometrically at the same time points. A high-dose of OLE did not influence blood pressure, heart rate or pTBARS in normotensive rats, while the SOD, catalase and glutathione reductase activities were significantly increased. The same dose significantly decreased blood pressure in hypertensive rats, but increased the pTBARS and SOD activity. Excessive oral intake of OLE induced moderate hypotensive effects only in spontaneously hypertensive rats, suggesting the absence of harmful hemodynamic effects after an oral overdose in both rat strains. However, its pro-oxidative role when given in a high dose in hypertensive organisms should not be neglected.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Effects of high dose olive leaf extract on the hemodynamic and oxidative stress parameters in normotensive and spontaneously hypertensive rats
EP  - 1097
IS  - 9
SP  - 1085
VL  - 79
DO  - 10.2298/JSC140218030D
ER  - 
@article{
author = "Dekanski, Dragana and Mihailović-Stanojević, Nevena and Grujić-Milanović, Jelica and Jovović, Đurđica and Miloradović, Zoran",
year = "2014",
abstract = "The antihypertensive activity of olive leaf extract (OLE), a natural antioxidant is recognized, but its influence on the cardiovascular system when administered in a high dose has not yet been investigated. The aim of the present study was to determine the acute effects of excessive intake of standardized OLE on blood pressure, heart rate and oxidative status in both spontaneously hypertensive rats and normotensive Wistar rats. The systolic arterial pressure and heart rate were measured using a tail-cuff and pneumatic pulse detector before and 60 and 120 min after intragastric OLE administration. The activities of catalase, glutathione peroxidase, superoxide dismutase (SOD) and glutathione reductase in erythrocytes, as well as lipid peroxidation in plasma (pTBARS) were measured spectrophotometrically at the same time points. A high-dose of OLE did not influence blood pressure, heart rate or pTBARS in normotensive rats, while the SOD, catalase and glutathione reductase activities were significantly increased. The same dose significantly decreased blood pressure in hypertensive rats, but increased the pTBARS and SOD activity. Excessive oral intake of OLE induced moderate hypotensive effects only in spontaneously hypertensive rats, suggesting the absence of harmful hemodynamic effects after an oral overdose in both rat strains. However, its pro-oxidative role when given in a high dose in hypertensive organisms should not be neglected.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Effects of high dose olive leaf extract on the hemodynamic and oxidative stress parameters in normotensive and spontaneously hypertensive rats",
pages = "1097-1085",
number = "9",
volume = "79",
doi = "10.2298/JSC140218030D"
}
Dekanski, D., Mihailović-Stanojević, N., Grujić-Milanović, J., Jovović, Đ.,& Miloradović, Z.. (2014). Effects of high dose olive leaf extract on the hemodynamic and oxidative stress parameters in normotensive and spontaneously hypertensive rats. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 79(9), 1085-1097.
https://doi.org/10.2298/JSC140218030D
conv_3342
Dekanski D, Mihailović-Stanojević N, Grujić-Milanović J, Jovović Đ, Miloradović Z. Effects of high dose olive leaf extract on the hemodynamic and oxidative stress parameters in normotensive and spontaneously hypertensive rats. in Journal of the Serbian Chemical Society. 2014;79(9):1085-1097.
doi:10.2298/JSC140218030D
conv_3342 .
Dekanski, Dragana, Mihailović-Stanojević, Nevena, Grujić-Milanović, Jelica, Jovović, Đurđica, Miloradović, Zoran, "Effects of high dose olive leaf extract on the hemodynamic and oxidative stress parameters in normotensive and spontaneously hypertensive rats" in Journal of the Serbian Chemical Society, 79, no. 9 (2014):1085-1097,
https://doi.org/10.2298/JSC140218030D .,
conv_3342 .

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