The importance of cardiovascular risk factors for thrombosis prediction in patients with essential thrombocythemia
Само за регистроване кориснике
2014
Аутори
Leković, DanijelaGotić, Mirjana
Milić, Nataša
Miljić, Predrag
Mitrović, Mirjana
Čokić, Vladan
Elezović, Ivo
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The current widely accepted stratification defined by age and previous thrombosis in patients with essential thrombocythemia (ET) probably deserves deeper analysis. The aim of our study was to identify additional factors at the time of diagnosis, which have an impact on the thrombosis prediction. We conducted a study of 244 consecutive ET patients with median follow-up of 83 months. We analyzed the influence of age, gender, laboratory parameters, history of previous thrombosis, spleen size, JAK2 mutation as well as cardiovascular (CV) risk factors including arterial hypertension, diabetes, active tobacco use and hyperlipidemia in the terms of thrombosis. The most important predictors of thrombosis in multivariate Cox regression model were the presence of CV risk factors (p = 0.004) and previous thrombosis (p = 0.038). Accordingly, we assigned risk scores based on multivariable analysis-derived hazard ratios (HR) to the presence of 1 CV risk factor (HR = 3.5; 1 point), gt 1 CV risk fac...tors (HR = 8.3; 2 points) and previous thrombosis (HR = 2.0; 1 point). A final three-tiered prognostic model for thrombosis prediction was developed as low (score 0), intermediate (score 1 or 2) and high risk (score 3) (p lt 0.001). The hazard of thrombosis was 3.8 % in low-risk group, 16.7 % in the intermediate-risk group and 60 % in the high-risk group (p lt 0.001). Patients with thrombotic complications during the follow-up had a significantly shorter survival (p = 0.018). The new score based on CV risk factors and previous thrombotic events allows a better patient selection within prognostic-risk groups and improved identification of the high-risk patients for thrombosis.
Кључне речи:
Thrombosis / Prediction / Essential thrombocythemia / Cardiovascular factors / Myeloproliferative neoplasmsИзвор:
Medical Oncology, 2014, 31, 10Издавач:
- Humana Press Inc, Totowa
Финансирање / пројекти:
- Испитивање патогенезе хематолошких малигнитета (RS-MESTD-Basic Research (BR or ON)-175053)
DOI: 10.1007/s12032-014-0231-1
ISSN: 1357-0560
PubMed: 25223529
WoS: 000342079600046
Scopus: 2-s2.0-84919921026
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Leković, Danijela AU - Gotić, Mirjana AU - Milić, Nataša AU - Miljić, Predrag AU - Mitrović, Mirjana AU - Čokić, Vladan AU - Elezović, Ivo PY - 2014 UR - http://rimi.imi.bg.ac.rs/handle/123456789/550 AB - The current widely accepted stratification defined by age and previous thrombosis in patients with essential thrombocythemia (ET) probably deserves deeper analysis. The aim of our study was to identify additional factors at the time of diagnosis, which have an impact on the thrombosis prediction. We conducted a study of 244 consecutive ET patients with median follow-up of 83 months. We analyzed the influence of age, gender, laboratory parameters, history of previous thrombosis, spleen size, JAK2 mutation as well as cardiovascular (CV) risk factors including arterial hypertension, diabetes, active tobacco use and hyperlipidemia in the terms of thrombosis. The most important predictors of thrombosis in multivariate Cox regression model were the presence of CV risk factors (p = 0.004) and previous thrombosis (p = 0.038). Accordingly, we assigned risk scores based on multivariable analysis-derived hazard ratios (HR) to the presence of 1 CV risk factor (HR = 3.5; 1 point), gt 1 CV risk factors (HR = 8.3; 2 points) and previous thrombosis (HR = 2.0; 1 point). A final three-tiered prognostic model for thrombosis prediction was developed as low (score 0), intermediate (score 1 or 2) and high risk (score 3) (p lt 0.001). The hazard of thrombosis was 3.8 % in low-risk group, 16.7 % in the intermediate-risk group and 60 % in the high-risk group (p lt 0.001). Patients with thrombotic complications during the follow-up had a significantly shorter survival (p = 0.018). The new score based on CV risk factors and previous thrombotic events allows a better patient selection within prognostic-risk groups and improved identification of the high-risk patients for thrombosis. PB - Humana Press Inc, Totowa T2 - Medical Oncology T1 - The importance of cardiovascular risk factors for thrombosis prediction in patients with essential thrombocythemia IS - 10 VL - 31 DO - 10.1007/s12032-014-0231-1 ER -
@article{ author = "Leković, Danijela and Gotić, Mirjana and Milić, Nataša and Miljić, Predrag and Mitrović, Mirjana and Čokić, Vladan and Elezović, Ivo", year = "2014", abstract = "The current widely accepted stratification defined by age and previous thrombosis in patients with essential thrombocythemia (ET) probably deserves deeper analysis. The aim of our study was to identify additional factors at the time of diagnosis, which have an impact on the thrombosis prediction. We conducted a study of 244 consecutive ET patients with median follow-up of 83 months. We analyzed the influence of age, gender, laboratory parameters, history of previous thrombosis, spleen size, JAK2 mutation as well as cardiovascular (CV) risk factors including arterial hypertension, diabetes, active tobacco use and hyperlipidemia in the terms of thrombosis. The most important predictors of thrombosis in multivariate Cox regression model were the presence of CV risk factors (p = 0.004) and previous thrombosis (p = 0.038). Accordingly, we assigned risk scores based on multivariable analysis-derived hazard ratios (HR) to the presence of 1 CV risk factor (HR = 3.5; 1 point), gt 1 CV risk factors (HR = 8.3; 2 points) and previous thrombosis (HR = 2.0; 1 point). A final three-tiered prognostic model for thrombosis prediction was developed as low (score 0), intermediate (score 1 or 2) and high risk (score 3) (p lt 0.001). The hazard of thrombosis was 3.8 % in low-risk group, 16.7 % in the intermediate-risk group and 60 % in the high-risk group (p lt 0.001). Patients with thrombotic complications during the follow-up had a significantly shorter survival (p = 0.018). The new score based on CV risk factors and previous thrombotic events allows a better patient selection within prognostic-risk groups and improved identification of the high-risk patients for thrombosis.", publisher = "Humana Press Inc, Totowa", journal = "Medical Oncology", title = "The importance of cardiovascular risk factors for thrombosis prediction in patients with essential thrombocythemia", number = "10", volume = "31", doi = "10.1007/s12032-014-0231-1" }
Leković, D., Gotić, M., Milić, N., Miljić, P., Mitrović, M., Čokić, V.,& Elezović, I.. (2014). The importance of cardiovascular risk factors for thrombosis prediction in patients with essential thrombocythemia. in Medical Oncology Humana Press Inc, Totowa., 31(10). https://doi.org/10.1007/s12032-014-0231-1
Leković D, Gotić M, Milić N, Miljić P, Mitrović M, Čokić V, Elezović I. The importance of cardiovascular risk factors for thrombosis prediction in patients with essential thrombocythemia. in Medical Oncology. 2014;31(10). doi:10.1007/s12032-014-0231-1 .
Leković, Danijela, Gotić, Mirjana, Milić, Nataša, Miljić, Predrag, Mitrović, Mirjana, Čokić, Vladan, Elezović, Ivo, "The importance of cardiovascular risk factors for thrombosis prediction in patients with essential thrombocythemia" in Medical Oncology, 31, no. 10 (2014), https://doi.org/10.1007/s12032-014-0231-1 . .