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dc.creatorĆirković, Ivana
dc.creatorPavlović, Ljiljana
dc.creatorKonstantinović, Neda M.
dc.creatorKostić, Katarina
dc.creatorJovanović, Snežana
dc.creatorĐukić, Slobodanka
dc.date.accessioned2021-04-20T12:37:43Z
dc.date.available2021-04-20T12:37:43Z
dc.date.issued2014
dc.identifier.issn0370-8179
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/546
dc.description.abstractIntroduction Beta-lactam antibiotics are the most commonly used antibacterial drugs. However, many bacteria have developed resistance to these antibiotics, and the most common form of resistance. is the production of beta-lactamase enzymes. Many members of the Enterobacteriaceae family produce different types of these enzymes. Objective The aim of this study was to perform phenotypic detection of production and identification of beta-lactamase type in Enterobacteriaceae isolated from different clinical specimens from patients hospitalized in the Clinical Center of Serbia. Methods The strains of Enterobacteriaceae were collected between November 2011 and January 2012 in the laboratory of the Clinical Center of Serbia. The isolates were identified according to the standard microbiology procedures and confirmed by the Vitek2 automated system. Antimicrobial susceptibility testing was performed by the disk diffusion method, and the phenotypic detection of production and identification of beta-lactamases was performed according to previously described methodologies. Results In this study, a total of 172 Enterobacteriaceae strains were isolated. Further testing was performed on 54/145 (37.2%) strains showing decreased susceptibility to beta-lactam antibiotics: 13/85 (15.3%) Escherichia coli, 31/46 (67.4%) Klebsiella pneumoniae and 10/14(71.4%) Proteus mirabilis. Among them, 40/145 (27.6%) strains produced extended spectrum beta-lactamases (ESBLs), 9/145 (6.2%) - AmpC, 1/145 (0.7%) - K1 beta-lactamase and 4/145 (2.8%) - carbapenemases. Carbapenemases were predominantly detected in K. pneumoniae (75%). Conclusion Enterobacteriaceae produce different types of beta-lactamases, and the most common type in our study was ESBLs. Production of carbapenemases detected in Enterobacteriaceae is also an associated problem.en
dc.publisherSrpsko lekarsko društvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175039/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceSrpski arhiv za celokupno lekarstvo
dc.subjectbeta-lactamasesen
dc.subjectenterobacteriaen
dc.subjectresistanceen
dc.titlePhenotypic Detection of Beta-Lactamases Production in Enterobacteriaceaeen
dc.typearticle
dc.rights.licenseBY-NC
dc.citation.epage463
dc.citation.issue7-8
dc.citation.other142(7-8): 457-463
dc.citation.rankM23
dc.citation.spage457
dc.citation.volume142
dc.identifier.doi10.2298/SARH1408457C
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/417/543.pdf
dc.identifier.pmid25233691
dc.identifier.scopus2-s2.0-84922622956
dc.identifier.wos000341069800009
dc.type.versionpublishedVersion


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