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Correlation between ER, PR, HER-2, Bcl-2, p53, proliferative and apoptotic indexes with HER-2 gene amplification and TOP2A gene amplification and deletion in four molecular subtypes of breast cancer
dc.creator | Mitrović, Olivera | |
dc.creator | Čokić, Vladan | |
dc.creator | Đikić, Dragoslava | |
dc.creator | Budeč, Mirela | |
dc.creator | Vignjević, Sanja | |
dc.creator | Subotički, Tijana | |
dc.creator | Gulan, Maja | |
dc.creator | Radović, Snežana | |
dc.creator | Furtula, Snežana | |
dc.date.accessioned | 2021-04-20T12:36:53Z | |
dc.date.available | 2021-04-20T12:36:53Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1776-2596 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/533 | |
dc.description.abstract | The aim of our study was to investigate HER-2 and TOP2A gene status and their correlation with Bcl-2, p53, Ki67, ssDNA, and clinicopathological parameters in four molecular subtypes of breast cancer. Seventy-four paraffin-embedded samples are immunohistochemically studied for the expression of estrogen receptor (ER), progesterone receptor (PR), HER-2, p53, Bcl-2, ssDNA, and Ki67, while HER-2 and TOP2A gene status by fluorescence in situ hybridization was investigated in 60 samples. Luminal A and B subtypes were characterized with small tumor size, intermediate histological grade, negative lymph node, and metastatic status, while triple negative and HER-2 positive subtypes were associated with larger tumor size, poorly differentiated tumors, and positive lymph node status. p53, Ki67, and ssDNA expression was higher in triple negative and HER-2 positive than in luminal subtypes, while ER, PR, and Bcl-2 dominated in luminal subtypes. HER-2 gene status was higher in luminal B and HER-2 positive than in luminal A and triple negative subtypes, while TOP2A gene status was similar. HER-2 gene status positively correlated with TOP2A gene status, HER-2 receptor, and histological grade, while negative correlation characterized relationship between HER-2 gene status and ER, PR, and Bcl-2. The shortened overall survival period characterized patients from triple negative breast cancer subtype (18.7 months). HER-2 and TOP2A gene amplification showed a tendency to be associated with larger tumor size, positive lymph node status, high level of apoptotic and proliferative indexes, and low level of p53 and Bcl-2 expression, which all together indicate group of patients with similar outcome during the progression of the disease. | en |
dc.publisher | Springer, Dordrecht | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175053/RS// | |
dc.rights | restrictedAccess | |
dc.source | Targeted Oncology | |
dc.subject | HER-2 | en |
dc.subject | TOP2A | en |
dc.subject | FISH | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Apoptosis | en |
dc.subject | Molecular subtypes of breast cancer | en |
dc.title | Correlation between ER, PR, HER-2, Bcl-2, p53, proliferative and apoptotic indexes with HER-2 gene amplification and TOP2A gene amplification and deletion in four molecular subtypes of breast cancer | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 379 | |
dc.citation.issue | 4 | |
dc.citation.other | 9(4): 367-379 | |
dc.citation.rank | M21 | |
dc.citation.spage | 367 | |
dc.citation.volume | 9 | |
dc.identifier.doi | 10.1007/s11523-013-0297-2 | |
dc.identifier.pmid | 24272208 | |
dc.identifier.scopus | 2-s2.0-84919482981 | |
dc.identifier.wos | 000347086400009 | |
dc.type.version | publishedVersion |