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dc.creatorTodorović, Vera
dc.creatorKoko, Vesna
dc.creatorPetakov, Marijana
dc.creatorJovčić, Gordana
dc.creatorStojanović, N.
dc.creatorBugarski, Diana
dc.creatorPerić, P
dc.date.accessioned2021-04-20T12:04:54Z
dc.date.available2021-04-20T12:04:54Z
dc.date.issued1999
dc.identifier.issn0971-5916
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/52
dc.description.abstractThe specific influence of malnutrition on the pathophysiologic changes induced by chronic alcoholism is controversial. In an attempt to determine and demarcate the effects of protein malnutrition from those produced by alcoholism and to evaluate the precise effect of alcohol per se on cytochemical and ultrastructural properties of rat polymorphonuclear neutrophil (PMN) granules, we investigated the influence of chronic protein malnutrition or chronic alcoholism alone and in combination, in rats, After a 4 month experimental period various PMN properties, such as cytochemical, morphometrical and ultrastructural, as well, as neutrophil functions were studied. It was found that the degree of damage of PMNs induced either by ethanol or protein malnutrition alone was similar whereas their combination led to worsening of all markers of PMN functional ability. Ultrastructural changes of neutrophil granules including reduction, redistribution and atypical accumulation as well as appearance of autophagic vacuoles, confirmed their alteration which was emphasised by the additive pathophysiological interaction of alcoholism and chronic hypoprotein malnutrition.en
dc.publisherWolters Kluwer Medknow Publications, Mumbai
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceIndian Journal of Medical Research
dc.subjectalcoholismen
dc.subjectpolymorphonuclear neutrophilen
dc.subjectprotein malnutritionen
dc.subjectultrastructural changesen
dc.titleCytochemical & ultrastructural alteration of cytoplasmic granules of rat peripheral blood neutrophils induced by chronic alcoholism & malnutritionen
dc.typearticle
dc.rights.licenseBY-NC-SA
dc.citation.epage114
dc.citation.other109: 105-114
dc.citation.rankM23
dc.citation.spage105
dc.citation.volume109
dc.identifier.pmid10489746
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_rimi_52
dc.identifier.wos000079780800006
dc.type.versionpublishedVersion


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