The specific influence of malnutrition on the pathophysiologic changes induced by chronic alcoholism is controversial. In an attempt to determine and demarcate the effects of protein malnutrition from those produced by alcoholism and to evaluate the precise effect of alcohol per se on cytochemical and ultrastructural properties of rat polymorphonuclear neutrophil (PMN) granules, we investigated the influence of chronic protein malnutrition or chronic alcoholism alone and in combination, in rats, After a 4 month experimental period various PMN properties, such as cytochemical, morphometrical and ultrastructural, as well, as neutrophil functions were studied. It was found that the degree of damage of PMNs induced either by ethanol or protein malnutrition alone was similar whereas their combination led to worsening of all markers of PMN functional ability. Ultrastructural changes of neutrophil granules including reduction, redistribution and atypical accumulation as well as appearance of ...autophagic vacuoles, confirmed their alteration which was emphasised by the additive pathophysiological interaction of alcoholism and chronic hypoprotein malnutrition.
Keywords:
alcoholism / polymorphonuclear neutrophil / protein malnutrition / ultrastructural changes
Source:
Indian Journal of Medical Research, 1999, 109, 105-114
TY - JOUR
AU - Todorović, Vera
AU - Koko, Vesna
AU - Petakov, Marijana
AU - Jovčić, Gordana
AU - Stojanović, N.
AU - Bugarski, Diana
AU - Perić, P
PY - 1999
UR - http://rimi.imi.bg.ac.rs/handle/123456789/52
AB - The specific influence of malnutrition on the pathophysiologic changes induced by chronic alcoholism is controversial. In an attempt to determine and demarcate the effects of protein malnutrition from those produced by alcoholism and to evaluate the precise effect of alcohol per se on cytochemical and ultrastructural properties of rat polymorphonuclear neutrophil (PMN) granules, we investigated the influence of chronic protein malnutrition or chronic alcoholism alone and in combination, in rats, After a 4 month experimental period various PMN properties, such as cytochemical, morphometrical and ultrastructural, as well, as neutrophil functions were studied. It was found that the degree of damage of PMNs induced either by ethanol or protein malnutrition alone was similar whereas their combination led to worsening of all markers of PMN functional ability. Ultrastructural changes of neutrophil granules including reduction, redistribution and atypical accumulation as well as appearance of autophagic vacuoles, confirmed their alteration which was emphasised by the additive pathophysiological interaction of alcoholism and chronic hypoprotein malnutrition.
PB - Wolters Kluwer Medknow Publications, Mumbai
T2 - Indian Journal of Medical Research
T1 - Cytochemical & ultrastructural alteration of cytoplasmic granules of rat peripheral blood neutrophils induced by chronic alcoholism & malnutrition
EP - 114
SP - 105
VL - 109
UR - https://hdl.handle.net/21.15107/rcub_rimi_52
ER -
@article{
author = "Todorović, Vera and Koko, Vesna and Petakov, Marijana and Jovčić, Gordana and Stojanović, N. and Bugarski, Diana and Perić, P",
year = "1999",
abstract = "The specific influence of malnutrition on the pathophysiologic changes induced by chronic alcoholism is controversial. In an attempt to determine and demarcate the effects of protein malnutrition from those produced by alcoholism and to evaluate the precise effect of alcohol per se on cytochemical and ultrastructural properties of rat polymorphonuclear neutrophil (PMN) granules, we investigated the influence of chronic protein malnutrition or chronic alcoholism alone and in combination, in rats, After a 4 month experimental period various PMN properties, such as cytochemical, morphometrical and ultrastructural, as well, as neutrophil functions were studied. It was found that the degree of damage of PMNs induced either by ethanol or protein malnutrition alone was similar whereas their combination led to worsening of all markers of PMN functional ability. Ultrastructural changes of neutrophil granules including reduction, redistribution and atypical accumulation as well as appearance of autophagic vacuoles, confirmed their alteration which was emphasised by the additive pathophysiological interaction of alcoholism and chronic hypoprotein malnutrition.",
publisher = "Wolters Kluwer Medknow Publications, Mumbai",
journal = "Indian Journal of Medical Research",
title = "Cytochemical & ultrastructural alteration of cytoplasmic granules of rat peripheral blood neutrophils induced by chronic alcoholism & malnutrition",
pages = "114-105",
volume = "109",
url = "https://hdl.handle.net/21.15107/rcub_rimi_52"
}
Todorović, V., Koko, V., Petakov, M., Jovčić, G., Stojanović, N., Bugarski, D.,& Perić, P.. (1999). Cytochemical & ultrastructural alteration of cytoplasmic granules of rat peripheral blood neutrophils induced by chronic alcoholism & malnutrition. in Indian Journal of Medical Research
Wolters Kluwer Medknow Publications, Mumbai., 109, 105-114.
https://hdl.handle.net/21.15107/rcub_rimi_52
Todorović V, Koko V, Petakov M, Jovčić G, Stojanović N, Bugarski D, Perić P. Cytochemical & ultrastructural alteration of cytoplasmic granules of rat peripheral blood neutrophils induced by chronic alcoholism & malnutrition. in Indian Journal of Medical Research. 1999;109:105-114.
https://hdl.handle.net/21.15107/rcub_rimi_52 .
Todorović, Vera, Koko, Vesna, Petakov, Marijana, Jovčić, Gordana, Stojanović, N., Bugarski, Diana, Perić, P, "Cytochemical & ultrastructural alteration of cytoplasmic granules of rat peripheral blood neutrophils induced by chronic alcoholism & malnutrition" in Indian Journal of Medical Research, 109 (1999):105-114,
https://hdl.handle.net/21.15107/rcub_rimi_52 .
