The role of dietary polyunsaturated fatty acids in inflammation
Uloga polinezasićenih masnih kiselina u inflamaciji
Apstrakt
Low-grade systemic inflammation is at the base of the most chronic non-communicable diseases, which are reaching epidemic proportions worldwide. Key players in the regulation of inflammation are n-6 and n-3 polyunsaturated fatty acids (PUFAs), in particular arachidonic acid (n-6) and eicosapentaenoic acid (n-3). They are precursors of eicosanoids - signaling molecules involved in modulating the intensity and duration of inflammatory responses. Eicosanoids derived from n-6 PUFAs have proinflammatory actions, while those derived from n-3 PUFAs act anti-inflammatory. Therefore, dietary intake of n-6 and n-3 PUFAs, as well as their ratio, could markedly affect the pathogenesis and manifestation of many chronic diseases associated with low-grade inflammation. This review will focus on the relationship between dietary PUFAs and inflammation, with reference to PUFAs status in plasma phospholipids in Serbian population.
U osnovi većine hroničnih nezaraznih bolesti, koje širom sveta dostižu epidemijske razmere, leži 'tiha' inflamacija. Ključni igrač u regulaciji inflamacije su polinezasićene masne kiseline (PNMK) n-6 i n-3 familije, posebno arahidonska (n-6) i eikozapentaenska kiselina (n-3). One su prekursori eikozanoida - signalnih molekula koji su uključeni u intenzitet i trajanje inflamatornog odgovora. Eikozanoidi poreklom od n-6 PNMK deluju proinflamatorno, dok oni poreklom od n-3 PNMK imaju anti-inflamatorno dejstvo. Zbog toga dijetarni unos n-6 i n-3 PNMK, kao i njihov odnos, može značajno da utiče na patogenezu i manifestaciju mnogih hroničnih oboljenja koja su povezana sa 'tihom' inflamacijom. Ovaj pregledni rad se bavi vezom između unosa PNMK i inflamacije, sa osvrtom na status n-3 i n-6 masnih kiselina u fosfolipidima plazme u populaciji u Srbiji.
Ključne reči:
polyunsaturated fatty acids / inflammation / arachidonic acid / eicosapentaenoic acid / eicosanoids / cytokines / polinezasićene masne kiseline / inflamacija / arahidonska kiselina / eiokozapentaenska kiselina / eikozanoidi / citokiniIzvor:
Serbian Journal of Experimental & Clinical Research, 2013, 14, 3, 93-99Izdavač:
- Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
Finansiranje / projekti:
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Vučić, Vesna M. PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/512 AB - Low-grade systemic inflammation is at the base of the most chronic non-communicable diseases, which are reaching epidemic proportions worldwide. Key players in the regulation of inflammation are n-6 and n-3 polyunsaturated fatty acids (PUFAs), in particular arachidonic acid (n-6) and eicosapentaenoic acid (n-3). They are precursors of eicosanoids - signaling molecules involved in modulating the intensity and duration of inflammatory responses. Eicosanoids derived from n-6 PUFAs have proinflammatory actions, while those derived from n-3 PUFAs act anti-inflammatory. Therefore, dietary intake of n-6 and n-3 PUFAs, as well as their ratio, could markedly affect the pathogenesis and manifestation of many chronic diseases associated with low-grade inflammation. This review will focus on the relationship between dietary PUFAs and inflammation, with reference to PUFAs status in plasma phospholipids in Serbian population. AB - U osnovi većine hroničnih nezaraznih bolesti, koje širom sveta dostižu epidemijske razmere, leži 'tiha' inflamacija. Ključni igrač u regulaciji inflamacije su polinezasićene masne kiseline (PNMK) n-6 i n-3 familije, posebno arahidonska (n-6) i eikozapentaenska kiselina (n-3). One su prekursori eikozanoida - signalnih molekula koji su uključeni u intenzitet i trajanje inflamatornog odgovora. Eikozanoidi poreklom od n-6 PNMK deluju proinflamatorno, dok oni poreklom od n-3 PNMK imaju anti-inflamatorno dejstvo. Zbog toga dijetarni unos n-6 i n-3 PNMK, kao i njihov odnos, može značajno da utiče na patogenezu i manifestaciju mnogih hroničnih oboljenja koja su povezana sa 'tihom' inflamacijom. Ovaj pregledni rad se bavi vezom između unosa PNMK i inflamacije, sa osvrtom na status n-3 i n-6 masnih kiselina u fosfolipidima plazme u populaciji u Srbiji. PB - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac T2 - Serbian Journal of Experimental & Clinical Research T1 - The role of dietary polyunsaturated fatty acids in inflammation T1 - Uloga polinezasićenih masnih kiselina u inflamaciji EP - 99 IS - 3 SP - 93 VL - 14 DO - 10.5937/sjecr14-4774 ER -
@article{ author = "Vučić, Vesna M.", year = "2013", abstract = "Low-grade systemic inflammation is at the base of the most chronic non-communicable diseases, which are reaching epidemic proportions worldwide. Key players in the regulation of inflammation are n-6 and n-3 polyunsaturated fatty acids (PUFAs), in particular arachidonic acid (n-6) and eicosapentaenoic acid (n-3). They are precursors of eicosanoids - signaling molecules involved in modulating the intensity and duration of inflammatory responses. Eicosanoids derived from n-6 PUFAs have proinflammatory actions, while those derived from n-3 PUFAs act anti-inflammatory. Therefore, dietary intake of n-6 and n-3 PUFAs, as well as their ratio, could markedly affect the pathogenesis and manifestation of many chronic diseases associated with low-grade inflammation. This review will focus on the relationship between dietary PUFAs and inflammation, with reference to PUFAs status in plasma phospholipids in Serbian population., U osnovi većine hroničnih nezaraznih bolesti, koje širom sveta dostižu epidemijske razmere, leži 'tiha' inflamacija. Ključni igrač u regulaciji inflamacije su polinezasićene masne kiseline (PNMK) n-6 i n-3 familije, posebno arahidonska (n-6) i eikozapentaenska kiselina (n-3). One su prekursori eikozanoida - signalnih molekula koji su uključeni u intenzitet i trajanje inflamatornog odgovora. Eikozanoidi poreklom od n-6 PNMK deluju proinflamatorno, dok oni poreklom od n-3 PNMK imaju anti-inflamatorno dejstvo. Zbog toga dijetarni unos n-6 i n-3 PNMK, kao i njihov odnos, može značajno da utiče na patogenezu i manifestaciju mnogih hroničnih oboljenja koja su povezana sa 'tihom' inflamacijom. Ovaj pregledni rad se bavi vezom između unosa PNMK i inflamacije, sa osvrtom na status n-3 i n-6 masnih kiselina u fosfolipidima plazme u populaciji u Srbiji.", publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac", journal = "Serbian Journal of Experimental & Clinical Research", title = "The role of dietary polyunsaturated fatty acids in inflammation, Uloga polinezasićenih masnih kiselina u inflamaciji", pages = "99-93", number = "3", volume = "14", doi = "10.5937/sjecr14-4774" }
Vučić, V. M.. (2013). The role of dietary polyunsaturated fatty acids in inflammation. in Serbian Journal of Experimental & Clinical Research Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 14(3), 93-99. https://doi.org/10.5937/sjecr14-4774
Vučić VM. The role of dietary polyunsaturated fatty acids in inflammation. in Serbian Journal of Experimental & Clinical Research. 2013;14(3):93-99. doi:10.5937/sjecr14-4774 .
Vučić, Vesna M., "The role of dietary polyunsaturated fatty acids in inflammation" in Serbian Journal of Experimental & Clinical Research, 14, no. 3 (2013):93-99, https://doi.org/10.5937/sjecr14-4774 . .