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The role of dietary polyunsaturated fatty acids in inflammation

Uloga polinezasićenih masnih kiselina u inflamaciji

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2013
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Authors
Vučić, Vesna M.
Article (Published version)
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Abstract
Low-grade systemic inflammation is at the base of the most chronic non-communicable diseases, which are reaching epidemic proportions worldwide. Key players in the regulation of inflammation are n-6 and n-3 polyunsaturated fatty acids (PUFAs), in particular arachidonic acid (n-6) and eicosapentaenoic acid (n-3). They are precursors of eicosanoids - signaling molecules involved in modulating the intensity and duration of inflammatory responses. Eicosanoids derived from n-6 PUFAs have proinflammatory actions, while those derived from n-3 PUFAs act anti-inflammatory. Therefore, dietary intake of n-6 and n-3 PUFAs, as well as their ratio, could markedly affect the pathogenesis and manifestation of many chronic diseases associated with low-grade inflammation. This review will focus on the relationship between dietary PUFAs and inflammation, with reference to PUFAs status in plasma phospholipids in Serbian population.
U osnovi većine hroničnih nezaraznih bolesti, koje širom sveta dostižu epidemijske razmere, leži 'tiha' inflamacija. Ključni igrač u regulaciji inflamacije su polinezasićene masne kiseline (PNMK) n-6 i n-3 familije, posebno arahidonska (n-6) i eikozapentaenska kiselina (n-3). One su prekursori eikozanoida - signalnih molekula koji su uključeni u intenzitet i trajanje inflamatornog odgovora. Eikozanoidi poreklom od n-6 PNMK deluju proinflamatorno, dok oni poreklom od n-3 PNMK imaju anti-inflamatorno dejstvo. Zbog toga dijetarni unos n-6 i n-3 PNMK, kao i njihov odnos, može značajno da utiče na patogenezu i manifestaciju mnogih hroničnih oboljenja koja su povezana sa 'tihom' inflamacijom. Ovaj pregledni rad se bavi vezom između unosa PNMK i inflamacije, sa osvrtom na status n-3 i n-6 masnih kiselina u fosfolipidima plazme u populaciji u Srbiji.
Keywords:
polyunsaturated fatty acids / inflammation / arachidonic acid / eicosapentaenoic acid / eicosanoids / cytokines / polinezasićene masne kiseline / inflamacija / arahidonska kiselina / eiokozapentaenska kiselina / eikozanoidi / citokini
Source:
Serbian Journal of Experimental & Clinical Research, 2013, 14, 3, 93-99
Publisher:
  • Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
Funding / projects:
  • Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-41030)

DOI: 10.5937/sjecr14-4774

ISSN: 1820-8665

Scopus: 2-s2.0-84888984565
[ Google Scholar ]
14
URI
http://rimi.imi.bg.ac.rs/handle/123456789/512
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Vučić, Vesna M.
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/512
AB  - Low-grade systemic inflammation is at the base of the most chronic non-communicable diseases, which are reaching epidemic proportions worldwide. Key players in the regulation of inflammation are n-6 and n-3 polyunsaturated fatty acids (PUFAs), in particular arachidonic acid (n-6) and eicosapentaenoic acid (n-3). They are precursors of eicosanoids - signaling molecules involved in modulating the intensity and duration of inflammatory responses. Eicosanoids derived from n-6 PUFAs have proinflammatory actions, while those derived from n-3 PUFAs act anti-inflammatory. Therefore, dietary intake of n-6 and n-3 PUFAs, as well as their ratio, could markedly affect the pathogenesis and manifestation of many chronic diseases associated with low-grade inflammation. This review will focus on the relationship between dietary PUFAs and inflammation, with reference to PUFAs status in plasma phospholipids in Serbian population.
AB  - U osnovi većine hroničnih nezaraznih bolesti, koje širom sveta dostižu epidemijske razmere, leži 'tiha' inflamacija. Ključni igrač u regulaciji inflamacije su polinezasićene masne kiseline (PNMK) n-6 i n-3 familije, posebno arahidonska (n-6) i eikozapentaenska kiselina (n-3). One su prekursori eikozanoida - signalnih molekula koji su uključeni u intenzitet i trajanje inflamatornog odgovora. Eikozanoidi poreklom od n-6 PNMK deluju proinflamatorno, dok oni poreklom od n-3 PNMK imaju anti-inflamatorno dejstvo. Zbog toga dijetarni unos n-6 i n-3 PNMK, kao i njihov odnos, može značajno da utiče na patogenezu i manifestaciju mnogih hroničnih oboljenja koja su povezana sa 'tihom' inflamacijom. Ovaj pregledni rad se bavi vezom između unosa PNMK i inflamacije, sa osvrtom na status n-3 i n-6 masnih kiselina u fosfolipidima plazme u populaciji u Srbiji.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Serbian Journal of Experimental & Clinical Research
T1  - The role of dietary polyunsaturated fatty acids in inflammation
T1  - Uloga polinezasićenih masnih kiselina u inflamaciji
EP  - 99
IS  - 3
SP  - 93
VL  - 14
DO  - 10.5937/sjecr14-4774
UR  - conv_1225
ER  - 
@article{
author = "Vučić, Vesna M.",
year = "2013",
abstract = "Low-grade systemic inflammation is at the base of the most chronic non-communicable diseases, which are reaching epidemic proportions worldwide. Key players in the regulation of inflammation are n-6 and n-3 polyunsaturated fatty acids (PUFAs), in particular arachidonic acid (n-6) and eicosapentaenoic acid (n-3). They are precursors of eicosanoids - signaling molecules involved in modulating the intensity and duration of inflammatory responses. Eicosanoids derived from n-6 PUFAs have proinflammatory actions, while those derived from n-3 PUFAs act anti-inflammatory. Therefore, dietary intake of n-6 and n-3 PUFAs, as well as their ratio, could markedly affect the pathogenesis and manifestation of many chronic diseases associated with low-grade inflammation. This review will focus on the relationship between dietary PUFAs and inflammation, with reference to PUFAs status in plasma phospholipids in Serbian population., U osnovi većine hroničnih nezaraznih bolesti, koje širom sveta dostižu epidemijske razmere, leži 'tiha' inflamacija. Ključni igrač u regulaciji inflamacije su polinezasićene masne kiseline (PNMK) n-6 i n-3 familije, posebno arahidonska (n-6) i eikozapentaenska kiselina (n-3). One su prekursori eikozanoida - signalnih molekula koji su uključeni u intenzitet i trajanje inflamatornog odgovora. Eikozanoidi poreklom od n-6 PNMK deluju proinflamatorno, dok oni poreklom od n-3 PNMK imaju anti-inflamatorno dejstvo. Zbog toga dijetarni unos n-6 i n-3 PNMK, kao i njihov odnos, može značajno da utiče na patogenezu i manifestaciju mnogih hroničnih oboljenja koja su povezana sa 'tihom' inflamacijom. Ovaj pregledni rad se bavi vezom između unosa PNMK i inflamacije, sa osvrtom na status n-3 i n-6 masnih kiselina u fosfolipidima plazme u populaciji u Srbiji.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Serbian Journal of Experimental & Clinical Research",
title = "The role of dietary polyunsaturated fatty acids in inflammation, Uloga polinezasićenih masnih kiselina u inflamaciji",
pages = "99-93",
number = "3",
volume = "14",
doi = "10.5937/sjecr14-4774",
url = "conv_1225"
}
Vučić, V. M.. (2013). The role of dietary polyunsaturated fatty acids in inflammation. in Serbian Journal of Experimental & Clinical Research
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 14(3), 93-99.
https://doi.org/10.5937/sjecr14-4774
conv_1225
Vučić VM. The role of dietary polyunsaturated fatty acids in inflammation. in Serbian Journal of Experimental & Clinical Research. 2013;14(3):93-99.
doi:10.5937/sjecr14-4774
conv_1225 .
Vučić, Vesna M., "The role of dietary polyunsaturated fatty acids in inflammation" in Serbian Journal of Experimental & Clinical Research, 14, no. 3 (2013):93-99,
https://doi.org/10.5937/sjecr14-4774 .,
conv_1225 .

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