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The emergence of non-secretory multiple myeloma during the non-cytotoxic treatment of essential thrombocythemia: A case report

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2013
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Authors
Leković, Danijela
Gotić, Mirjana
Mitrović, Olivera
Radojković, M.
Bila, J.
Dencic-Fekete, Marija
Kraguljac-Kurtović, Nada
Peruničić-Jovanović, Maja
Čokić, Vladan
Article (Published version)
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Abstract
Introduction. The emergence of multiple myeloma as a second malignancy in patients with essential thrombocythemia is extremely rare. Several cases have been published so far, pointing out the impact of a cytotoxic effect during treatment of essential thrombocythemia on the development of multiple myeloma. Case presentation. We report the case of a 52-year-old Caucasian man who presented to our hospital because of leukocytosis, a slightly decreased hemoglobin level and thrombocytosis. After a complete hematological work-up, essential thrombocythemia was diagnosed. The patient was included in a multicenter clinical study, treated with anagrelide and his platelet counts were maintained in the normal range for more than 3 years. A sudden drop in his hemoglobin level with normal leukocyte and platelet count occurred at the same time as a back pain. Magnetic resonance imaging of his spine revealed the existence of a pathological fracture of Th4, the collapse of the upper edge of Th7 and oste...olytic lesions of multiple thoracic vertebrae. Repeated hematological examinations, including bone biopsy with immunohistochemistry, disclosed diagnosis of multiple myeloma of the non-secretory type. Conclusions: To the best of our knowledge this is the first published case in which multiple myeloma developed during the treatment of essential thrombocythemia with the non-cytotoxic drug anagrelide. Our attempts to find a common origin for the coexistence of multiple myeloma and essential thrombocythemia have not confirmed the genetic basis of their appearance. Further studies are needed to determine the biological impact of this coexistence.

Keywords:
Angiogenesis / Essential thrombocythemia / Multiple myeloma
Source:
Journal of Medical Case Reports, 2013, 7

DOI: 10.1186/1752-1947-7-224

ISSN: 1752-1947

Scopus: 2-s2.0-84883671634
[ Google Scholar ]
1
URI
http://rimi.imi.bg.ac.rs/handle/123456789/511
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Leković, Danijela
AU  - Gotić, Mirjana
AU  - Mitrović, Olivera
AU  - Radojković, M.
AU  - Bila, J.
AU  - Dencic-Fekete, Marija
AU  - Kraguljac-Kurtović, Nada
AU  - Peruničić-Jovanović, Maja
AU  - Čokić, Vladan
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/511
AB  - Introduction. The emergence of multiple myeloma as a second malignancy in patients with essential thrombocythemia is extremely rare. Several cases have been published so far, pointing out the impact of a cytotoxic effect during treatment of essential thrombocythemia on the development of multiple myeloma. Case presentation. We report the case of a 52-year-old Caucasian man who presented to our hospital because of leukocytosis, a slightly decreased hemoglobin level and thrombocytosis. After a complete hematological work-up, essential thrombocythemia was diagnosed. The patient was included in a multicenter clinical study, treated with anagrelide and his platelet counts were maintained in the normal range for more than 3 years. A sudden drop in his hemoglobin level with normal leukocyte and platelet count occurred at the same time as a back pain. Magnetic resonance imaging of his spine revealed the existence of a pathological fracture of Th4, the collapse of the upper edge of Th7 and osteolytic lesions of multiple thoracic vertebrae. Repeated hematological examinations, including bone biopsy with immunohistochemistry, disclosed diagnosis of multiple myeloma of the non-secretory type. Conclusions: To the best of our knowledge this is the first published case in which multiple myeloma developed during the treatment of essential thrombocythemia with the non-cytotoxic drug anagrelide. Our attempts to find a common origin for the coexistence of multiple myeloma and essential thrombocythemia have not confirmed the genetic basis of their appearance. Further studies are needed to determine the biological impact of this coexistence.
T2  - Journal of Medical Case Reports
T1  - The emergence of non-secretory multiple myeloma during the non-cytotoxic treatment of essential thrombocythemia: A case report
VL  - 7
DO  - 10.1186/1752-1947-7-224
UR  - conv_5204
ER  - 
@article{
author = "Leković, Danijela and Gotić, Mirjana and Mitrović, Olivera and Radojković, M. and Bila, J. and Dencic-Fekete, Marija and Kraguljac-Kurtović, Nada and Peruničić-Jovanović, Maja and Čokić, Vladan",
year = "2013",
abstract = "Introduction. The emergence of multiple myeloma as a second malignancy in patients with essential thrombocythemia is extremely rare. Several cases have been published so far, pointing out the impact of a cytotoxic effect during treatment of essential thrombocythemia on the development of multiple myeloma. Case presentation. We report the case of a 52-year-old Caucasian man who presented to our hospital because of leukocytosis, a slightly decreased hemoglobin level and thrombocytosis. After a complete hematological work-up, essential thrombocythemia was diagnosed. The patient was included in a multicenter clinical study, treated with anagrelide and his platelet counts were maintained in the normal range for more than 3 years. A sudden drop in his hemoglobin level with normal leukocyte and platelet count occurred at the same time as a back pain. Magnetic resonance imaging of his spine revealed the existence of a pathological fracture of Th4, the collapse of the upper edge of Th7 and osteolytic lesions of multiple thoracic vertebrae. Repeated hematological examinations, including bone biopsy with immunohistochemistry, disclosed diagnosis of multiple myeloma of the non-secretory type. Conclusions: To the best of our knowledge this is the first published case in which multiple myeloma developed during the treatment of essential thrombocythemia with the non-cytotoxic drug anagrelide. Our attempts to find a common origin for the coexistence of multiple myeloma and essential thrombocythemia have not confirmed the genetic basis of their appearance. Further studies are needed to determine the biological impact of this coexistence.",
journal = "Journal of Medical Case Reports",
title = "The emergence of non-secretory multiple myeloma during the non-cytotoxic treatment of essential thrombocythemia: A case report",
volume = "7",
doi = "10.1186/1752-1947-7-224",
url = "conv_5204"
}
Leković, D., Gotić, M., Mitrović, O., Radojković, M., Bila, J., Dencic-Fekete, M., Kraguljac-Kurtović, N., Peruničić-Jovanović, M.,& Čokić, V.. (2013). The emergence of non-secretory multiple myeloma during the non-cytotoxic treatment of essential thrombocythemia: A case report. in Journal of Medical Case Reports, 7.
https://doi.org/10.1186/1752-1947-7-224
conv_5204
Leković D, Gotić M, Mitrović O, Radojković M, Bila J, Dencic-Fekete M, Kraguljac-Kurtović N, Peruničić-Jovanović M, Čokić V. The emergence of non-secretory multiple myeloma during the non-cytotoxic treatment of essential thrombocythemia: A case report. in Journal of Medical Case Reports. 2013;7.
doi:10.1186/1752-1947-7-224
conv_5204 .
Leković, Danijela, Gotić, Mirjana, Mitrović, Olivera, Radojković, M., Bila, J., Dencic-Fekete, Marija, Kraguljac-Kurtović, Nada, Peruničić-Jovanović, Maja, Čokić, Vladan, "The emergence of non-secretory multiple myeloma during the non-cytotoxic treatment of essential thrombocythemia: A case report" in Journal of Medical Case Reports, 7 (2013),
https://doi.org/10.1186/1752-1947-7-224 .,
conv_5204 .

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