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Hypolipidemic and antioxidant effects of buckwheat leaf and flower mixture in hyperlipidemic rats

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2013
497.pdf (486.6Kb)
Authors
Durendic-Brenesel, Maja
Popović, Tamara B.
Pilija, Vladimir
Arsić, Aleksandra Č.
Milić, Miljan
Kojić, Danijela
Jojić, Nikola
Milić, Nataša
Article (Published version)
Publisher's own license
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Abstract
As a source of biologically active compounds, buckwheat has beneficial effects in nutrition due to its high content of flavonoids, particularly rutin. Aim of our study was to examine effects of buckwheat on plasma lipid status and phospholipids fatty acids composition, histological and parameters of oxidative stress in Wistar rats fed a high-fat diet. This study showed that buckwheat leaf and flower (BLF) mixture supplementation significantly reduce weight gain, plasma lipid concentrations and atherogenic index in rats fed a high-fat diet. Treatment of the high-fat group of animals with buckwheat significantly increased percentage of n-6 fatty acids as well as eicosapentaenoic acid (EPA) and decreased percentage of saturated fatty acids (SPA) and oleic acid. Buckwheat antioxidant effects diminished negative influence of high-fat diet in hyperlipidemic rats, while pathohistological analysis of liver confirmed changes after high-fat consumption. Our results showed hypolipidemic, antiathe...rogenic and antioxidative features of buckwheat leaf and flower mixture, and these parts of the plant with the highest rutin content could be beneficial in prevention and curing of hyperlipidemia.

Keywords:
buckwheat / plasma lipids / plasma phospholipids fatty acids / oxidative stress / hypolipidemic effect
Source:
Bosnian Journal of Basic Medical Sciences, 2013, 13, 2, 100-108
Publisher:
  • Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa
Funding / projects:
  • Functional Cereal Based Products for People with Metabolic Disorder (RS-31029)

DOI: 10.17305/bjbms.2013.2389

ISSN: 1512-8601

PubMed: 23725506

WoS: 000330925000007

Scopus: 2-s2.0-84883795107
[ Google Scholar ]
21
18
URI
http://rimi.imi.bg.ac.rs/handle/123456789/500
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Durendic-Brenesel, Maja
AU  - Popović, Tamara B.
AU  - Pilija, Vladimir
AU  - Arsić, Aleksandra Č.
AU  - Milić, Miljan
AU  - Kojić, Danijela
AU  - Jojić, Nikola
AU  - Milić, Nataša
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/500
AB  - As a source of biologically active compounds, buckwheat has beneficial effects in nutrition due to its high content of flavonoids, particularly rutin. Aim of our study was to examine effects of buckwheat on plasma lipid status and phospholipids fatty acids composition, histological and parameters of oxidative stress in Wistar rats fed a high-fat diet. This study showed that buckwheat leaf and flower (BLF) mixture supplementation significantly reduce weight gain, plasma lipid concentrations and atherogenic index in rats fed a high-fat diet. Treatment of the high-fat group of animals with buckwheat significantly increased percentage of n-6 fatty acids as well as eicosapentaenoic acid (EPA) and decreased percentage of saturated fatty acids (SPA) and oleic acid. Buckwheat antioxidant effects diminished negative influence of high-fat diet in hyperlipidemic rats, while pathohistological analysis of liver confirmed changes after high-fat consumption. Our results showed hypolipidemic, antiatherogenic and antioxidative features of buckwheat leaf and flower mixture, and these parts of the plant with the highest rutin content could be beneficial in prevention and curing of hyperlipidemia.
PB  - Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa
T2  - Bosnian Journal of Basic Medical Sciences
T1  - Hypolipidemic and antioxidant effects of buckwheat leaf and flower mixture in hyperlipidemic rats
EP  - 108
IS  - 2
SP  - 100
VL  - 13
DO  - 10.17305/bjbms.2013.2389
UR  - conv_2848
ER  - 
@article{
author = "Durendic-Brenesel, Maja and Popović, Tamara B. and Pilija, Vladimir and Arsić, Aleksandra Č. and Milić, Miljan and Kojić, Danijela and Jojić, Nikola and Milić, Nataša",
year = "2013",
abstract = "As a source of biologically active compounds, buckwheat has beneficial effects in nutrition due to its high content of flavonoids, particularly rutin. Aim of our study was to examine effects of buckwheat on plasma lipid status and phospholipids fatty acids composition, histological and parameters of oxidative stress in Wistar rats fed a high-fat diet. This study showed that buckwheat leaf and flower (BLF) mixture supplementation significantly reduce weight gain, plasma lipid concentrations and atherogenic index in rats fed a high-fat diet. Treatment of the high-fat group of animals with buckwheat significantly increased percentage of n-6 fatty acids as well as eicosapentaenoic acid (EPA) and decreased percentage of saturated fatty acids (SPA) and oleic acid. Buckwheat antioxidant effects diminished negative influence of high-fat diet in hyperlipidemic rats, while pathohistological analysis of liver confirmed changes after high-fat consumption. Our results showed hypolipidemic, antiatherogenic and antioxidative features of buckwheat leaf and flower mixture, and these parts of the plant with the highest rutin content could be beneficial in prevention and curing of hyperlipidemia.",
publisher = "Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa",
journal = "Bosnian Journal of Basic Medical Sciences",
title = "Hypolipidemic and antioxidant effects of buckwheat leaf and flower mixture in hyperlipidemic rats",
pages = "108-100",
number = "2",
volume = "13",
doi = "10.17305/bjbms.2013.2389",
url = "conv_2848"
}
Durendic-Brenesel, M., Popović, T. B., Pilija, V., Arsić, A. Č., Milić, M., Kojić, D., Jojić, N.,& Milić, N.. (2013). Hypolipidemic and antioxidant effects of buckwheat leaf and flower mixture in hyperlipidemic rats. in Bosnian Journal of Basic Medical Sciences
Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa., 13(2), 100-108.
https://doi.org/10.17305/bjbms.2013.2389
conv_2848
Durendic-Brenesel M, Popović TB, Pilija V, Arsić AČ, Milić M, Kojić D, Jojić N, Milić N. Hypolipidemic and antioxidant effects of buckwheat leaf and flower mixture in hyperlipidemic rats. in Bosnian Journal of Basic Medical Sciences. 2013;13(2):100-108.
doi:10.17305/bjbms.2013.2389
conv_2848 .
Durendic-Brenesel, Maja, Popović, Tamara B., Pilija, Vladimir, Arsić, Aleksandra Č., Milić, Miljan, Kojić, Danijela, Jojić, Nikola, Milić, Nataša, "Hypolipidemic and antioxidant effects of buckwheat leaf and flower mixture in hyperlipidemic rats" in Bosnian Journal of Basic Medical Sciences, 13, no. 2 (2013):100-108,
https://doi.org/10.17305/bjbms.2013.2389 .,
conv_2848 .

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