RIMI - Repository of the Institute for Medical Research
Institute for Medical Research
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   RIMI
  • Institut za medicinska istraživanja
  • Radovi istraživača / Researchers' publications
  • View Item
  •   RIMI
  • Institut za medicinska istraživanja
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis

Authorized Users Only
2021
Authors
Karanović, Danijela
Mihailović-Stanojević, Nevena
Miloradović, Zoran
Ivanov, Milan
Vajić, Una-Jovana
Grujić-Milanović, Jelica
Marković-Lipkovski, Jasmina
Dekanski, Dragana
Jovović, Đurđica
Article (Published version)
Metadata
Show full item record
Abstract
Olive (Olea europaea L.) leaf extract (OLE) possesses powerful antioxidant, antihyperlipidemic, and anti-inflammatory properties. The aim was to investigated the effects of OLE on the hyperlipidemia, antioxidant defense, heme oxygenase/biliverdin reductase (HO/BVR) pathway, inflammation, and fibrosis in spontaneously hypertensive rats with focal segmental glomerulosclerosis (FSGS, a progressive form of chronic kidney disease) induced by adriamycin (2 mg/kg, i.v., twice in a 21-day period). Daily treatment of OLE (80 mg/kg, p.o.) for 6 weeks suppressed protein oxidation and lipid peroxidation (p lt .01 and p lt .001, respectively), significantly increased antioxidant enzymes activities and normalized antioxidant capacity, leading to the improvement of antioxidant defense independently of the HO/BVR pathway. Furthermore, the values of triglycerides (p lt .01), total, and low-density lipoprotein cholesterol (p lt .05, both) were improved by OLE. OLE strongly prevented glomeruloscl...erosis, interstitial inflammation, and fibrosis (renal injury score, FSGS: 8 +/- 0.45 vs. FSGS+OLE: 4.20 +/- 1.07; p lt .01), as evidenced by normalized fibronectin content (p lt .001), suppressed interstitial inflammatory cells infiltration and collagen deposition, without changing cytokines expressions. OLE decreased blood pressure with a tendency to reduce urine albumin loss. These data suggest that OLE may be effective in slowing down the progression of FSGS.

Keywords:
adriamycin nephropathy / fibronectin / hyperlipidemia / hypertension / olive leaf / oxidative stress
Source:
Phytotherapy Research, 2021, 35, 3, 1534-1545
Publisher:
  • Wiley, Hoboken
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)

DOI: 10.1002/ptr.6920

ISSN: 0951-418X

PubMed: 33098170

WoS: 000581577200001

Scopus: 2-s2.0-85093499173
[ Google Scholar ]
6
4
URI
http://rimi.imi.bg.ac.rs/handle/123456789/5
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Karanović, Danijela
AU  - Mihailović-Stanojević, Nevena
AU  - Miloradović, Zoran
AU  - Ivanov, Milan
AU  - Vajić, Una-Jovana
AU  - Grujić-Milanović, Jelica
AU  - Marković-Lipkovski, Jasmina
AU  - Dekanski, Dragana
AU  - Jovović, Đurđica
PY  - 2021
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/5
AB  - Olive (Olea europaea L.) leaf extract (OLE) possesses powerful antioxidant, antihyperlipidemic, and anti-inflammatory properties. The aim was to investigated the effects of OLE on the hyperlipidemia, antioxidant defense, heme oxygenase/biliverdin reductase (HO/BVR) pathway, inflammation, and fibrosis in spontaneously hypertensive rats with focal segmental glomerulosclerosis (FSGS, a progressive form of chronic kidney disease) induced by adriamycin (2 mg/kg, i.v., twice in a 21-day period). Daily treatment of OLE (80 mg/kg, p.o.) for 6 weeks suppressed protein oxidation and lipid peroxidation (p  lt  .01 and p  lt  .001, respectively), significantly increased antioxidant enzymes activities and normalized antioxidant capacity, leading to the improvement of antioxidant defense independently of the HO/BVR pathway. Furthermore, the values of triglycerides (p  lt  .01), total, and low-density lipoprotein cholesterol (p  lt  .05, both) were improved by OLE. OLE strongly prevented glomerulosclerosis, interstitial inflammation, and fibrosis (renal injury score, FSGS: 8 +/- 0.45 vs. FSGS+OLE: 4.20 +/- 1.07; p  lt  .01), as evidenced by normalized fibronectin content (p  lt  .001), suppressed interstitial inflammatory cells infiltration and collagen deposition, without changing cytokines expressions. OLE decreased blood pressure with a tendency to reduce urine albumin loss. These data suggest that OLE may be effective in slowing down the progression of FSGS.
PB  - Wiley, Hoboken
T2  - Phytotherapy Research
T1  - Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis
EP  - 1545
IS  - 3
SP  - 1534
VL  - 35
DO  - 10.1002/ptr.6920
UR  - conv_4887
ER  - 
@article{
author = "Karanović, Danijela and Mihailović-Stanojević, Nevena and Miloradović, Zoran and Ivanov, Milan and Vajić, Una-Jovana and Grujić-Milanović, Jelica and Marković-Lipkovski, Jasmina and Dekanski, Dragana and Jovović, Đurđica",
year = "2021",
abstract = "Olive (Olea europaea L.) leaf extract (OLE) possesses powerful antioxidant, antihyperlipidemic, and anti-inflammatory properties. The aim was to investigated the effects of OLE on the hyperlipidemia, antioxidant defense, heme oxygenase/biliverdin reductase (HO/BVR) pathway, inflammation, and fibrosis in spontaneously hypertensive rats with focal segmental glomerulosclerosis (FSGS, a progressive form of chronic kidney disease) induced by adriamycin (2 mg/kg, i.v., twice in a 21-day period). Daily treatment of OLE (80 mg/kg, p.o.) for 6 weeks suppressed protein oxidation and lipid peroxidation (p  lt  .01 and p  lt  .001, respectively), significantly increased antioxidant enzymes activities and normalized antioxidant capacity, leading to the improvement of antioxidant defense independently of the HO/BVR pathway. Furthermore, the values of triglycerides (p  lt  .01), total, and low-density lipoprotein cholesterol (p  lt  .05, both) were improved by OLE. OLE strongly prevented glomerulosclerosis, interstitial inflammation, and fibrosis (renal injury score, FSGS: 8 +/- 0.45 vs. FSGS+OLE: 4.20 +/- 1.07; p  lt  .01), as evidenced by normalized fibronectin content (p  lt  .001), suppressed interstitial inflammatory cells infiltration and collagen deposition, without changing cytokines expressions. OLE decreased blood pressure with a tendency to reduce urine albumin loss. These data suggest that OLE may be effective in slowing down the progression of FSGS.",
publisher = "Wiley, Hoboken",
journal = "Phytotherapy Research",
title = "Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis",
pages = "1545-1534",
number = "3",
volume = "35",
doi = "10.1002/ptr.6920",
url = "conv_4887"
}
Karanović, D., Mihailović-Stanojević, N., Miloradović, Z., Ivanov, M., Vajić, U., Grujić-Milanović, J., Marković-Lipkovski, J., Dekanski, D.,& Jovović, Đ.. (2021). Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis. in Phytotherapy Research
Wiley, Hoboken., 35(3), 1534-1545.
https://doi.org/10.1002/ptr.6920
conv_4887
Karanović D, Mihailović-Stanojević N, Miloradović Z, Ivanov M, Vajić U, Grujić-Milanović J, Marković-Lipkovski J, Dekanski D, Jovović Đ. Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis. in Phytotherapy Research. 2021;35(3):1534-1545.
doi:10.1002/ptr.6920
conv_4887 .
Karanović, Danijela, Mihailović-Stanojević, Nevena, Miloradović, Zoran, Ivanov, Milan, Vajić, Una-Jovana, Grujić-Milanović, Jelica, Marković-Lipkovski, Jasmina, Dekanski, Dragana, Jovović, Đurđica, "Olive leaf extract attenuates adriamycin-induced focal segmental glomerulosclerosis in spontaneously hypertensive rats via suppression of oxidative stress, hyperlipidemia, and fibrosis" in Phytotherapy Research, 35, no. 3 (2021):1534-1545,
https://doi.org/10.1002/ptr.6920 .,
conv_4887 .

DSpace software copyright © 2002-2015  DuraSpace
About RIMI | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About RIMI | Send Feedback

OpenAIRERCUB