Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension
Samo za registrovane korisnike
2013
Autori
Mihailović-Stanojević, NevenaBelscak-Cvitanović, Ana
Grujić-Milanović, Jelica
Ivanov, Milan
Jovović, Đurđica
Bugarski, Diana
Miloradović, Zoran
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The low incidence of cardiovascular disease in Mediterranean countries leads to an increased interest of the scientific community for the Mediterranean diet. Our aim was to evaluate total phenol and flavonoid contents, antioxidant capacity, free radical scavenging activity and potential antihypertensive effect of aqueous extract obtained from Thymus serpyllum L. (wild thyme, TE), an aromatic herb from the Lamiaceae family (highly present in Mediterranean diet), in spontaneously hypertensive rats (SHR) and in normotensive Wistar rats. Total phenol content of TE was 2008.33 +/- 10.6 mg/L GAE, and rosmarinic and caffeic acids were predominant phenolic compounds. The ferric reducing/antioxidant power and antioxidant capacity analysis revealed strong antioxidative properties of TE. In vitro nitric oxide-scavenging activity of 1 mg/l TE was 63.43 % with the IC50 value of 122.36 mu g/ml. Bolus injection of TE (100 mg/kg body weight i.v.) induced significant decrease of systolic and diastolic ...blood pressure and total peripheral resistance in SHR, without effects on these parameters in normotensive Wistar rats. Cardiac index remained unchanged after TE treatment in all experimental rats. Given dose of TE did not show significant nitric oxide-scavenging activity in vivo. Our results indicate that TE may protect against hypertension in experimental model of essential hypertension.
Ključne reči:
Wild thyme / Antioxidant / Hypertension / Mediterranean diet / Blood pressure / Peripheral resistance / Nitric oxide / Spontaneously hypertensive rats / Rosmarinic acidIzvor:
Plant Foods for Human Nutrition, 2013, 68, 3, 235-240Izdavač:
- Springer, Dordrecht
Finansiranje / projekti:
- Razvoj novih inkapsulacionih i enzimskih tehnologija za proizvodnju biokatalizatora i biološki aktivnih komponenata hrane u cilju povećanja njene konkurentnosti, kvaliteta i bezbednosti (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
- Ministry of Science, Education and Sports, Republic of Croatia [058-0000000-3470]
- Croatia-Serbia Bilateral agreement [69-00-49/2010-02]
DOI: 10.1007/s11130-013-0368-7
ISSN: 0921-9668
PubMed: 23828496
WoS: 000323667000004
Scopus: 2-s2.0-84883296822
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Mihailović-Stanojević, Nevena AU - Belscak-Cvitanović, Ana AU - Grujić-Milanović, Jelica AU - Ivanov, Milan AU - Jovović, Đurđica AU - Bugarski, Diana AU - Miloradović, Zoran PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/497 AB - The low incidence of cardiovascular disease in Mediterranean countries leads to an increased interest of the scientific community for the Mediterranean diet. Our aim was to evaluate total phenol and flavonoid contents, antioxidant capacity, free radical scavenging activity and potential antihypertensive effect of aqueous extract obtained from Thymus serpyllum L. (wild thyme, TE), an aromatic herb from the Lamiaceae family (highly present in Mediterranean diet), in spontaneously hypertensive rats (SHR) and in normotensive Wistar rats. Total phenol content of TE was 2008.33 +/- 10.6 mg/L GAE, and rosmarinic and caffeic acids were predominant phenolic compounds. The ferric reducing/antioxidant power and antioxidant capacity analysis revealed strong antioxidative properties of TE. In vitro nitric oxide-scavenging activity of 1 mg/l TE was 63.43 % with the IC50 value of 122.36 mu g/ml. Bolus injection of TE (100 mg/kg body weight i.v.) induced significant decrease of systolic and diastolic blood pressure and total peripheral resistance in SHR, without effects on these parameters in normotensive Wistar rats. Cardiac index remained unchanged after TE treatment in all experimental rats. Given dose of TE did not show significant nitric oxide-scavenging activity in vivo. Our results indicate that TE may protect against hypertension in experimental model of essential hypertension. PB - Springer, Dordrecht T2 - Plant Foods for Human Nutrition T1 - Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension EP - 240 IS - 3 SP - 235 VL - 68 DO - 10.1007/s11130-013-0368-7 ER -
@article{ author = "Mihailović-Stanojević, Nevena and Belscak-Cvitanović, Ana and Grujić-Milanović, Jelica and Ivanov, Milan and Jovović, Đurđica and Bugarski, Diana and Miloradović, Zoran", year = "2013", abstract = "The low incidence of cardiovascular disease in Mediterranean countries leads to an increased interest of the scientific community for the Mediterranean diet. Our aim was to evaluate total phenol and flavonoid contents, antioxidant capacity, free radical scavenging activity and potential antihypertensive effect of aqueous extract obtained from Thymus serpyllum L. (wild thyme, TE), an aromatic herb from the Lamiaceae family (highly present in Mediterranean diet), in spontaneously hypertensive rats (SHR) and in normotensive Wistar rats. Total phenol content of TE was 2008.33 +/- 10.6 mg/L GAE, and rosmarinic and caffeic acids were predominant phenolic compounds. The ferric reducing/antioxidant power and antioxidant capacity analysis revealed strong antioxidative properties of TE. In vitro nitric oxide-scavenging activity of 1 mg/l TE was 63.43 % with the IC50 value of 122.36 mu g/ml. Bolus injection of TE (100 mg/kg body weight i.v.) induced significant decrease of systolic and diastolic blood pressure and total peripheral resistance in SHR, without effects on these parameters in normotensive Wistar rats. Cardiac index remained unchanged after TE treatment in all experimental rats. Given dose of TE did not show significant nitric oxide-scavenging activity in vivo. Our results indicate that TE may protect against hypertension in experimental model of essential hypertension.", publisher = "Springer, Dordrecht", journal = "Plant Foods for Human Nutrition", title = "Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension", pages = "240-235", number = "3", volume = "68", doi = "10.1007/s11130-013-0368-7" }
Mihailović-Stanojević, N., Belscak-Cvitanović, A., Grujić-Milanović, J., Ivanov, M., Jovović, Đ., Bugarski, D.,& Miloradović, Z.. (2013). Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension. in Plant Foods for Human Nutrition Springer, Dordrecht., 68(3), 235-240. https://doi.org/10.1007/s11130-013-0368-7
Mihailović-Stanojević N, Belscak-Cvitanović A, Grujić-Milanović J, Ivanov M, Jovović Đ, Bugarski D, Miloradović Z. Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension. in Plant Foods for Human Nutrition. 2013;68(3):235-240. doi:10.1007/s11130-013-0368-7 .
Mihailović-Stanojević, Nevena, Belscak-Cvitanović, Ana, Grujić-Milanović, Jelica, Ivanov, Milan, Jovović, Đurđica, Bugarski, Diana, Miloradović, Zoran, "Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension" in Plant Foods for Human Nutrition, 68, no. 3 (2013):235-240, https://doi.org/10.1007/s11130-013-0368-7 . .