The low incidence of cardiovascular disease in Mediterranean countries leads to an increased interest of the scientific community for the Mediterranean diet. Our aim was to evaluate total phenol and flavonoid contents, antioxidant capacity, free radical scavenging activity and potential antihypertensive effect of aqueous extract obtained from Thymus serpyllum L. (wild thyme, TE), an aromatic herb from the Lamiaceae family (highly present in Mediterranean diet), in spontaneously hypertensive rats (SHR) and in normotensive Wistar rats. Total phenol content of TE was 2008.33 +/- 10.6 mg/L GAE, and rosmarinic and caffeic acids were predominant phenolic compounds. The ferric reducing/antioxidant power and antioxidant capacity analysis revealed strong antioxidative properties of TE. In vitro nitric oxide-scavenging activity of 1 mg/l TE was 63.43 % with the IC50 value of 122.36 mu g/ml. Bolus injection of TE (100 mg/kg body weight i.v.) induced significant decrease of systolic and diastolic ...blood pressure and total peripheral resistance in SHR, without effects on these parameters in normotensive Wistar rats. Cardiac index remained unchanged after TE treatment in all experimental rats. Given dose of TE did not show significant nitric oxide-scavenging activity in vivo. Our results indicate that TE may protect against hypertension in experimental model of essential hypertension.
TY - JOUR
AU - Mihailović-Stanojević, Nevena
AU - Belscak-Cvitanović, Ana
AU - Grujić-Milanović, Jelica
AU - Ivanov, Milan
AU - Jovović, Đurđica
AU - Bugarski, Diana
AU - Miloradović, Zoran
PY - 2013
UR - http://rimi.imi.bg.ac.rs/handle/123456789/497
AB - The low incidence of cardiovascular disease in Mediterranean countries leads to an increased interest of the scientific community for the Mediterranean diet. Our aim was to evaluate total phenol and flavonoid contents, antioxidant capacity, free radical scavenging activity and potential antihypertensive effect of aqueous extract obtained from Thymus serpyllum L. (wild thyme, TE), an aromatic herb from the Lamiaceae family (highly present in Mediterranean diet), in spontaneously hypertensive rats (SHR) and in normotensive Wistar rats. Total phenol content of TE was 2008.33 +/- 10.6 mg/L GAE, and rosmarinic and caffeic acids were predominant phenolic compounds. The ferric reducing/antioxidant power and antioxidant capacity analysis revealed strong antioxidative properties of TE. In vitro nitric oxide-scavenging activity of 1 mg/l TE was 63.43 % with the IC50 value of 122.36 mu g/ml. Bolus injection of TE (100 mg/kg body weight i.v.) induced significant decrease of systolic and diastolic blood pressure and total peripheral resistance in SHR, without effects on these parameters in normotensive Wistar rats. Cardiac index remained unchanged after TE treatment in all experimental rats. Given dose of TE did not show significant nitric oxide-scavenging activity in vivo. Our results indicate that TE may protect against hypertension in experimental model of essential hypertension.
PB - Springer, Dordrecht
T2 - Plant Foods for Human Nutrition
T1 - Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension
EP - 240
IS - 3
SP - 235
VL - 68
DO - 10.1007/s11130-013-0368-7
ER -
@article{
author = "Mihailović-Stanojević, Nevena and Belscak-Cvitanović, Ana and Grujić-Milanović, Jelica and Ivanov, Milan and Jovović, Đurđica and Bugarski, Diana and Miloradović, Zoran",
year = "2013",
abstract = "The low incidence of cardiovascular disease in Mediterranean countries leads to an increased interest of the scientific community for the Mediterranean diet. Our aim was to evaluate total phenol and flavonoid contents, antioxidant capacity, free radical scavenging activity and potential antihypertensive effect of aqueous extract obtained from Thymus serpyllum L. (wild thyme, TE), an aromatic herb from the Lamiaceae family (highly present in Mediterranean diet), in spontaneously hypertensive rats (SHR) and in normotensive Wistar rats. Total phenol content of TE was 2008.33 +/- 10.6 mg/L GAE, and rosmarinic and caffeic acids were predominant phenolic compounds. The ferric reducing/antioxidant power and antioxidant capacity analysis revealed strong antioxidative properties of TE. In vitro nitric oxide-scavenging activity of 1 mg/l TE was 63.43 % with the IC50 value of 122.36 mu g/ml. Bolus injection of TE (100 mg/kg body weight i.v.) induced significant decrease of systolic and diastolic blood pressure and total peripheral resistance in SHR, without effects on these parameters in normotensive Wistar rats. Cardiac index remained unchanged after TE treatment in all experimental rats. Given dose of TE did not show significant nitric oxide-scavenging activity in vivo. Our results indicate that TE may protect against hypertension in experimental model of essential hypertension.",
publisher = "Springer, Dordrecht",
journal = "Plant Foods for Human Nutrition",
title = "Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension",
pages = "240-235",
number = "3",
volume = "68",
doi = "10.1007/s11130-013-0368-7"
}
Mihailović-Stanojević, N., Belscak-Cvitanović, A., Grujić-Milanović, J., Ivanov, M., Jovović, Đ., Bugarski, D.,& Miloradović, Z.. (2013). Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension. in Plant Foods for Human Nutrition
Springer, Dordrecht., 68(3), 235-240.
https://doi.org/10.1007/s11130-013-0368-7
conv_3044
Mihailović-Stanojević N, Belscak-Cvitanović A, Grujić-Milanović J, Ivanov M, Jovović Đ, Bugarski D, Miloradović Z. Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension. in Plant Foods for Human Nutrition. 2013;68(3):235-240.
doi:10.1007/s11130-013-0368-7
conv_3044 .
Mihailović-Stanojević, Nevena, Belscak-Cvitanović, Ana, Grujić-Milanović, Jelica, Ivanov, Milan, Jovović, Đurđica, Bugarski, Diana, Miloradović, Zoran, "Antioxidant and Antihypertensive Activity of Extract from Thymus serpyllum L. in Experimental Hypertension" in Plant Foods for Human Nutrition, 68, no. 3 (2013):235-240,
https://doi.org/10.1007/s11130-013-0368-7 .,
conv_3044 .
