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GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells
dc.creator | Okić Đorđević, Ivana | |
dc.creator | Trivanović, Drenka | |
dc.creator | Krstić, Jelena | |
dc.creator | Jauković, Aleksandra | |
dc.creator | Mojsilović, S. | |
dc.creator | Santibanez, Juan F. | |
dc.creator | Terzić, Milan | |
dc.creator | Vesović, D. | |
dc.creator | Bugarski, Diana | |
dc.date.accessioned | 2021-04-20T12:34:13Z | |
dc.date.available | 2021-04-20T12:34:13Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1107-0625 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/491 | |
dc.description.abstract | Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals. | en |
dc.publisher | Balkan Union of Oncology (B.U.ON.) | |
dc.relation | International Health Corporation, Belgrade, Serbia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of BUON | |
dc.subject | antiproliferative effect | en |
dc.subject | breast cancer | en |
dc.subject | colon cancer | en |
dc.subject | dietary supplement GE132+Natural | en |
dc.subject | prostate cancer | en |
dc.title | GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 510 | |
dc.citation.issue | 2 | |
dc.citation.other | 18(2): 504-510 | |
dc.citation.rank | M23 | |
dc.citation.spage | 504 | |
dc.citation.volume | 18 | |
dc.identifier.pmid | 23818369 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_rimi_491 | |
dc.identifier.wos | 000322750700031 | |
dc.type.version | publishedVersion |
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