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dc.creatorOkić Đorđević, Ivana
dc.creatorTrivanović, Drenka
dc.creatorKrstić, Jelena
dc.creatorJauković, Aleksandra
dc.creatorMojsilović, S.
dc.creatorSantibanez, Juan F.
dc.creatorTerzić, Milan
dc.creatorVesović, D.
dc.creatorBugarski, Diana
dc.description.abstractPurpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.en
dc.publisherBalkan Union of Oncology (B.U.ON.)
dc.relationInternational Health Corporation, Belgrade, Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS//
dc.sourceJournal of BUON
dc.subjectantiproliferative effecten
dc.subjectbreast canceren
dc.subjectcolon canceren
dc.subjectdietary supplement GE132+Naturalen
dc.subjectprostate canceren
dc.titleGE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cellsen
dc.citation.other18(2): 504-510

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