GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells
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Okić Đorđević, IvanaTrivanović, Drenka
Krstić, Jelena
Jauković, Aleksandra
Mojsilović, S.
Santibanez, Juan F.
Terzić, Milan
Vesović, D.
Bugarski, Diana
Article (Published version)
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Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent m...anner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.
Keywords:
antiproliferative effect / breast cancer / colon cancer / dietary supplement GE132+Natural / prostate cancerSource:
Journal of BUON, 2013, 18, 2, 504-510Publisher:
- Balkan Union of Oncology (B.U.ON.)
Funding / projects:
- International Health Corporation, Belgrade, Serbia
- Regenerative and modulatory potential of adult stem cells (RS-MESTD-Basic Research (BR or ON)-175062)
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Institut za medicinska istraživanjaTY - JOUR AU - Okić Đorđević, Ivana AU - Trivanović, Drenka AU - Krstić, Jelena AU - Jauković, Aleksandra AU - Mojsilović, S. AU - Santibanez, Juan F. AU - Terzić, Milan AU - Vesović, D. AU - Bugarski, Diana PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/491 AB - Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals. PB - Balkan Union of Oncology (B.U.ON.) T2 - Journal of BUON T1 - GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells EP - 510 IS - 2 SP - 504 VL - 18 UR - https://hdl.handle.net/21.15107/rcub_rimi_491 ER -
@article{ author = "Okić Đorđević, Ivana and Trivanović, Drenka and Krstić, Jelena and Jauković, Aleksandra and Mojsilović, S. and Santibanez, Juan F. and Terzić, Milan and Vesović, D. and Bugarski, Diana", year = "2013", abstract = "Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.", publisher = "Balkan Union of Oncology (B.U.ON.)", journal = "Journal of BUON", title = "GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells", pages = "510-504", number = "2", volume = "18", url = "https://hdl.handle.net/21.15107/rcub_rimi_491" }
Okić Đorđević, I., Trivanović, D., Krstić, J., Jauković, A., Mojsilović, S., Santibanez, J. F., Terzić, M., Vesović, D.,& Bugarski, D.. (2013). GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. in Journal of BUON Balkan Union of Oncology (B.U.ON.)., 18(2), 504-510. https://hdl.handle.net/21.15107/rcub_rimi_491
Okić Đorđević I, Trivanović D, Krstić J, Jauković A, Mojsilović S, Santibanez JF, Terzić M, Vesović D, Bugarski D. GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. in Journal of BUON. 2013;18(2):504-510. https://hdl.handle.net/21.15107/rcub_rimi_491 .
Okić Đorđević, Ivana, Trivanović, Drenka, Krstić, Jelena, Jauković, Aleksandra, Mojsilović, S., Santibanez, Juan F., Terzić, Milan, Vesović, D., Bugarski, Diana, "GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells" in Journal of BUON, 18, no. 2 (2013):504-510, https://hdl.handle.net/21.15107/rcub_rimi_491 .