Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent m...anner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.
Keywords:
antiproliferative effect / breast cancer / colon cancer / dietary supplement GE132+Natural / prostate cancer
Source:
Journal of BUON, 2013, 18, 2, 504-510
Publisher:
Balkan Union of Oncology (B.U.ON.)
Funding / projects:
International Health Corporation, Belgrade, Serbia
TY - JOUR
AU - Okić-Đorđević, Ivana
AU - Trivanović, Drenka
AU - Krstić, Jelena
AU - Jauković, Aleksandra
AU - Mojsilović, S.
AU - Santibanez, Juan
AU - Terzić, Milan
AU - Vesović, D.
AU - Bugarski, Diana
PY - 2013
UR - http://rimi.imi.bg.ac.rs/handle/123456789/491
AB - Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.
PB - Balkan Union of Oncology (B.U.ON.)
T2 - Journal of BUON
T1 - GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells
EP - 510
IS - 2
SP - 504
VL - 18
UR - https://hdl.handle.net/21.15107/rcub_rimi_491
ER -
@article{
author = "Okić-Đorđević, Ivana and Trivanović, Drenka and Krstić, Jelena and Jauković, Aleksandra and Mojsilović, S. and Santibanez, Juan and Terzić, Milan and Vesović, D. and Bugarski, Diana",
year = "2013",
abstract = "Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells",
pages = "510-504",
number = "2",
volume = "18",
url = "https://hdl.handle.net/21.15107/rcub_rimi_491"
}
Okić-Đorđević, I., Trivanović, D., Krstić, J., Jauković, A., Mojsilović, S., Santibanez, J., Terzić, M., Vesović, D.,& Bugarski, D.. (2013). GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 18(2), 504-510.
https://hdl.handle.net/21.15107/rcub_rimi_491
Okić-Đorđević I, Trivanović D, Krstić J, Jauković A, Mojsilović S, Santibanez J, Terzić M, Vesović D, Bugarski D. GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. in Journal of BUON. 2013;18(2):504-510.
https://hdl.handle.net/21.15107/rcub_rimi_491 .
Okić-Đorđević, Ivana, Trivanović, Drenka, Krstić, Jelena, Jauković, Aleksandra, Mojsilović, S., Santibanez, Juan, Terzić, Milan, Vesović, D., Bugarski, Diana, "GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells" in Journal of BUON, 18, no. 2 (2013):504-510,
https://hdl.handle.net/21.15107/rcub_rimi_491 .
