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Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells

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Authors
Miletić, Maja
Mojsilović, S.
Okić-Đorđević, Ivana
Maletić, Dejan
Puač, Nevena
Lazović, Saša
Malović, Gordana
Milenković, P.
Petrović, Zoran Lj.
Bugarski, Diana
Article (Published version)
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Abstract
Here we investigate the influences of non-thermal atmospheric plasma on human mesenchymal stem cells isolated from periodontal ligament (hPDL-MSCs). A specially redesigned plasma needle was used as the source of low-temperature plasma and its effects on different hPDL-MSC functions were investigated. Cell cultures were obtained from extracted normal impacted third molars and characterized for their phenotype and multi-potential differentiation. The hPDL-MSCs possessed all the typical MSC properties, including clonogenic ability, high proliferation rate, specific phenotype and multilineage differentiation. The data regarding the interaction of plasma with hPDL-MSCs demonstrated that plasma treatment inhibited the migration of hPDL-MSCs and induced some detachment, while not affecting their viability. Additionally, plasma significantly attenuated hPDL-MSCs' proliferation, but promoted their osteogenic differentiation. The results of this study indicated that a non-thermal plasma offers s...pecific activity with non-destructive properties that can be advantageous for future dental applications.

Source:
Journal of Physics D-Applied Physics, 2013, 46, 34
Publisher:
  • Iop Publishing Ltd, Bristol
Funding / projects:
  • Regenerative and modulatory potential of adult stem cells (RS-175062)
  • Fundamental processes and applications of particle transport in non-equilibrium plasmas, traps and nanostructures (RS-171037)
  • Application of low temperature plasmas in biomedicine, environmental protection and nanotechnologies (RS-41011)

DOI: 10.1088/0022-3727/46/34/345401

ISSN: 0022-3727

WoS: 000323062400017

Scopus: 2-s2.0-84882360715
[ Google Scholar ]
39
33
URI
http://rimi.imi.bg.ac.rs/handle/123456789/487
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Miletić, Maja
AU  - Mojsilović, S.
AU  - Okić-Đorđević, Ivana
AU  - Maletić, Dejan
AU  - Puač, Nevena
AU  - Lazović, Saša
AU  - Malović, Gordana
AU  - Milenković, P.
AU  - Petrović, Zoran Lj.
AU  - Bugarski, Diana
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/487
AB  - Here we investigate the influences of non-thermal atmospheric plasma on human mesenchymal stem cells isolated from periodontal ligament (hPDL-MSCs). A specially redesigned plasma needle was used as the source of low-temperature plasma and its effects on different hPDL-MSC functions were investigated. Cell cultures were obtained from extracted normal impacted third molars and characterized for their phenotype and multi-potential differentiation. The hPDL-MSCs possessed all the typical MSC properties, including clonogenic ability, high proliferation rate, specific phenotype and multilineage differentiation. The data regarding the interaction of plasma with hPDL-MSCs demonstrated that plasma treatment inhibited the migration of hPDL-MSCs and induced some detachment, while not affecting their viability. Additionally, plasma significantly attenuated hPDL-MSCs' proliferation, but promoted their osteogenic differentiation. The results of this study indicated that a non-thermal plasma offers specific activity with non-destructive properties that can be advantageous for future dental applications.
PB  - Iop Publishing Ltd, Bristol
T2  - Journal of Physics D-Applied Physics
T1  - Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells
IS  - 34
VL  - 46
DO  - 10.1088/0022-3727/46/34/345401
UR  - conv_3031
ER  - 
@article{
author = "Miletić, Maja and Mojsilović, S. and Okić-Đorđević, Ivana and Maletić, Dejan and Puač, Nevena and Lazović, Saša and Malović, Gordana and Milenković, P. and Petrović, Zoran Lj. and Bugarski, Diana",
year = "2013",
abstract = "Here we investigate the influences of non-thermal atmospheric plasma on human mesenchymal stem cells isolated from periodontal ligament (hPDL-MSCs). A specially redesigned plasma needle was used as the source of low-temperature plasma and its effects on different hPDL-MSC functions were investigated. Cell cultures were obtained from extracted normal impacted third molars and characterized for their phenotype and multi-potential differentiation. The hPDL-MSCs possessed all the typical MSC properties, including clonogenic ability, high proliferation rate, specific phenotype and multilineage differentiation. The data regarding the interaction of plasma with hPDL-MSCs demonstrated that plasma treatment inhibited the migration of hPDL-MSCs and induced some detachment, while not affecting their viability. Additionally, plasma significantly attenuated hPDL-MSCs' proliferation, but promoted their osteogenic differentiation. The results of this study indicated that a non-thermal plasma offers specific activity with non-destructive properties that can be advantageous for future dental applications.",
publisher = "Iop Publishing Ltd, Bristol",
journal = "Journal of Physics D-Applied Physics",
title = "Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells",
number = "34",
volume = "46",
doi = "10.1088/0022-3727/46/34/345401",
url = "conv_3031"
}
Miletić, M., Mojsilović, S., Okić-Đorđević, I., Maletić, D., Puač, N., Lazović, S., Malović, G., Milenković, P., Petrović, Z. Lj.,& Bugarski, D.. (2013). Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells. in Journal of Physics D-Applied Physics
Iop Publishing Ltd, Bristol., 46(34).
https://doi.org/10.1088/0022-3727/46/34/345401
conv_3031
Miletić M, Mojsilović S, Okić-Đorđević I, Maletić D, Puač N, Lazović S, Malović G, Milenković P, Petrović ZL, Bugarski D. Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells. in Journal of Physics D-Applied Physics. 2013;46(34).
doi:10.1088/0022-3727/46/34/345401
conv_3031 .
Miletić, Maja, Mojsilović, S., Okić-Đorđević, Ivana, Maletić, Dejan, Puač, Nevena, Lazović, Saša, Malović, Gordana, Milenković, P., Petrović, Zoran Lj., Bugarski, Diana, "Effects of non-thermal atmospheric plasma on human periodontal ligament mesenchymal stem cells" in Journal of Physics D-Applied Physics, 46, no. 34 (2013),
https://doi.org/10.1088/0022-3727/46/34/345401 .,
conv_3031 .

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