Polyunsaturated fatty acids in health and disease
Polinezasićene masne kiseline u zdravlju i bolesti
Апстракт
Polyunsaturated fatty acids (PUFAs) are necessary for overall health. Two PUFAs families, n-6 and n-3 fatty acids, are physiologically and metabolically distinct. The proportion of PUFAs in serum and erythrocyte phospholipids, which depends on endogenous metabolism controlled by genetic polymorphisms and dietary intake, is an important determinant of both health and disease. Both n-3 and n-6 PUFAs are processed to powerful promoters of eicosanoids synthesis at the cyclooxygenase and lipoxygenase level. Evidence from observational and intervention studies suggest that n-3 PUFAs are cardio-protective, perhaps through their anti-inflammatory, anti-arrhythmic, lipid-lowering and antihypertensive effects. In contrast, dietary n-6 PUFAs have pro-inflammatory effects. Low n-3 and elevated n-6 PUFAs levels were found in patients with cancer on different sites. The present review focuses on current knowledge related to PUFAs intake and status in health and disease, with reference to the Serbia...n population.
Polinezasićene masne kiseline (PMK) su neophodne za normalno funkcionisanje organizma. Dve PMK familije, n-6 i n-3 masne kiseline se fiziološki i metabolički razlikuju. Udeo PMK u fosfolipidima seruma i eritrocita je važan pokazatelj zdravlja i bolesti, i zavisi od endogenog metabolizma, koji je kontrolisan genetskim polimorfizmom, i unosa hrane. I n-6 i n-3 PMK su prekursori za sintezu eikozanoida na ciklooksigenaznom i lipooksigenaznom nivou. Opservacione i interventne studije ukazuju da n-3 PMK imaju kardioprotektivni efekat, delujući anti-inflamatorno, anti-aritmogeno, hipolipidemično i antihipertenzivno. Nasuprot tome, smatra se da n-6 PMK imaju pro-inflamatorno dejstvo. Nizak nivo n-3 i povišen udeo n-6 PMK je pokazan kod pacijenata sa različitim tipovima maligniteta. U okviru ovog rada dat je pregled najnovijih saznanja o dijetarnom unosu i biomarkerima statusa PMK u promociji zdravlja i prevenciji bolesti, sa posebnim osvrtom na rezultate u našoj populaciji.
Кључне речи:
n-3 / n-6 / PUFA / inflammation / cardiovascular disease / chronic diseasesИзвор:
Journal of the Serbian Chemical Society, 2013, 78, 9, 1269-1289Издавач:
- Srpsko hemijsko društvo, Beograd
Финансирање / пројекти:
- Биолошки механизми, нутритивни унос и статус полинезасићених масних киселина и фолата: Унапређење исхране у Србији (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
DOI: 10.2298/JSC130402040R
ISSN: 0352-5139
WoS: 000326199200001
Scopus: 2-s2.0-84885168109
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Ristić-Medić, Danijela AU - Vučić, Vesna M. AU - Takić, Marija AU - Karadžić, Ivana AU - Glibetić, Marija PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/483 AB - Polyunsaturated fatty acids (PUFAs) are necessary for overall health. Two PUFAs families, n-6 and n-3 fatty acids, are physiologically and metabolically distinct. The proportion of PUFAs in serum and erythrocyte phospholipids, which depends on endogenous metabolism controlled by genetic polymorphisms and dietary intake, is an important determinant of both health and disease. Both n-3 and n-6 PUFAs are processed to powerful promoters of eicosanoids synthesis at the cyclooxygenase and lipoxygenase level. Evidence from observational and intervention studies suggest that n-3 PUFAs are cardio-protective, perhaps through their anti-inflammatory, anti-arrhythmic, lipid-lowering and antihypertensive effects. In contrast, dietary n-6 PUFAs have pro-inflammatory effects. Low n-3 and elevated n-6 PUFAs levels were found in patients with cancer on different sites. The present review focuses on current knowledge related to PUFAs intake and status in health and disease, with reference to the Serbian population. AB - Polinezasićene masne kiseline (PMK) su neophodne za normalno funkcionisanje organizma. Dve PMK familije, n-6 i n-3 masne kiseline se fiziološki i metabolički razlikuju. Udeo PMK u fosfolipidima seruma i eritrocita je važan pokazatelj zdravlja i bolesti, i zavisi od endogenog metabolizma, koji je kontrolisan genetskim polimorfizmom, i unosa hrane. I n-6 i n-3 PMK su prekursori za sintezu eikozanoida na ciklooksigenaznom i lipooksigenaznom nivou. Opservacione i interventne studije ukazuju da n-3 PMK imaju kardioprotektivni efekat, delujući anti-inflamatorno, anti-aritmogeno, hipolipidemično i antihipertenzivno. Nasuprot tome, smatra se da n-6 PMK imaju pro-inflamatorno dejstvo. Nizak nivo n-3 i povišen udeo n-6 PMK je pokazan kod pacijenata sa različitim tipovima maligniteta. U okviru ovog rada dat je pregled najnovijih saznanja o dijetarnom unosu i biomarkerima statusa PMK u promociji zdravlja i prevenciji bolesti, sa posebnim osvrtom na rezultate u našoj populaciji. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Polyunsaturated fatty acids in health and disease T1 - Polinezasićene masne kiseline u zdravlju i bolesti EP - 1289 IS - 9 SP - 1269 VL - 78 DO - 10.2298/JSC130402040R ER -
@article{ author = "Ristić-Medić, Danijela and Vučić, Vesna M. and Takić, Marija and Karadžić, Ivana and Glibetić, Marija", year = "2013", abstract = "Polyunsaturated fatty acids (PUFAs) are necessary for overall health. Two PUFAs families, n-6 and n-3 fatty acids, are physiologically and metabolically distinct. The proportion of PUFAs in serum and erythrocyte phospholipids, which depends on endogenous metabolism controlled by genetic polymorphisms and dietary intake, is an important determinant of both health and disease. Both n-3 and n-6 PUFAs are processed to powerful promoters of eicosanoids synthesis at the cyclooxygenase and lipoxygenase level. Evidence from observational and intervention studies suggest that n-3 PUFAs are cardio-protective, perhaps through their anti-inflammatory, anti-arrhythmic, lipid-lowering and antihypertensive effects. In contrast, dietary n-6 PUFAs have pro-inflammatory effects. Low n-3 and elevated n-6 PUFAs levels were found in patients with cancer on different sites. The present review focuses on current knowledge related to PUFAs intake and status in health and disease, with reference to the Serbian population., Polinezasićene masne kiseline (PMK) su neophodne za normalno funkcionisanje organizma. Dve PMK familije, n-6 i n-3 masne kiseline se fiziološki i metabolički razlikuju. Udeo PMK u fosfolipidima seruma i eritrocita je važan pokazatelj zdravlja i bolesti, i zavisi od endogenog metabolizma, koji je kontrolisan genetskim polimorfizmom, i unosa hrane. I n-6 i n-3 PMK su prekursori za sintezu eikozanoida na ciklooksigenaznom i lipooksigenaznom nivou. Opservacione i interventne studije ukazuju da n-3 PMK imaju kardioprotektivni efekat, delujući anti-inflamatorno, anti-aritmogeno, hipolipidemično i antihipertenzivno. Nasuprot tome, smatra se da n-6 PMK imaju pro-inflamatorno dejstvo. Nizak nivo n-3 i povišen udeo n-6 PMK je pokazan kod pacijenata sa različitim tipovima maligniteta. U okviru ovog rada dat je pregled najnovijih saznanja o dijetarnom unosu i biomarkerima statusa PMK u promociji zdravlja i prevenciji bolesti, sa posebnim osvrtom na rezultate u našoj populaciji.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Polyunsaturated fatty acids in health and disease, Polinezasićene masne kiseline u zdravlju i bolesti", pages = "1289-1269", number = "9", volume = "78", doi = "10.2298/JSC130402040R" }
Ristić-Medić, D., Vučić, V. M., Takić, M., Karadžić, I.,& Glibetić, M.. (2013). Polyunsaturated fatty acids in health and disease. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 78(9), 1269-1289. https://doi.org/10.2298/JSC130402040R
Ristić-Medić D, Vučić VM, Takić M, Karadžić I, Glibetić M. Polyunsaturated fatty acids in health and disease. in Journal of the Serbian Chemical Society. 2013;78(9):1269-1289. doi:10.2298/JSC130402040R .
Ristić-Medić, Danijela, Vučić, Vesna M., Takić, Marija, Karadžić, Ivana, Glibetić, Marija, "Polyunsaturated fatty acids in health and disease" in Journal of the Serbian Chemical Society, 78, no. 9 (2013):1269-1289, https://doi.org/10.2298/JSC130402040R . .