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Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function

Authorized Users Only
2013
Authors
Hollands, Wendy J.
Saha, Shikha
Hayran, Osman
Boyko, Nadiya
Glibetić, Marija
Konić-Ristić, Aleksandra
Jorjadze, Mariam
Kroon, Paul A.
Article (Published version)
Metadata
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Abstract
BACKGROUNDThe health benefits of fruit and vegetable-rich diets may be partly due to modulation of platelet activity by bioactive phytochemicals. The aim of this study was to investigate the effects of bioactive-rich plant extracts and isolated bioactive metabolites on platelet function. Blood samples (n =15 subjects) were treated with extracts of bioactive-rich plants consumed as traditional foods in the Black Sea region, or with human metabolites of the bioactives quercetin and sulforaphane. Platelet function was assessed using the PFA-100. RESULTSNone of the extracts containing various flavonoids, glucosinolates and other bioactives, or isolated bioactive metabolites of quercetin or sulforaphane, caused significant changes in PFA-100 closure time (CT). In contrast, the positive controls (aspirin and Abciximab) consistently caused significant increases in CT for the platelet agonists epinephrine and ADP, respectively. CONCLUSIONThese data do not support the notion that these plant bi...oactives can improve human platelet function.

Keywords:
polyphenols / flavonoids / platelets / in vitro / PFA-100
Source:
Journal of the Science of Food & Agriculture, 2013, 93, 14, 3588-3594
Publisher:
  • Wiley, Hoboken
Funding / projects:
  • Sustainable exploitation of bioactive components from the Black Sea Area traditional foods (EU-227118)
  • project BaSeFood
  • UK Research & Innovation (UKRI) Biotechnology and Biological Sciences Research Council (BBSRC) [BB/J004545/1]
  • UK Research & Innovation (UKRI) Biotechnology and Biological Sciences Research Council (BBSRC) [BBS/E/F/00044434]

DOI: 10.1002/jsfa.6213

ISSN: 0022-5142

PubMed: 23649552

WoS: 000328279500022

Scopus: 2-s2.0-84885857171
[ Google Scholar ]
9
7
URI
http://rimi.imi.bg.ac.rs/handle/123456789/478
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Hollands, Wendy J.
AU  - Saha, Shikha
AU  - Hayran, Osman
AU  - Boyko, Nadiya
AU  - Glibetić, Marija
AU  - Konić-Ristić, Aleksandra
AU  - Jorjadze, Mariam
AU  - Kroon, Paul A.
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/478
AB  - BACKGROUNDThe health benefits of fruit and vegetable-rich diets may be partly due to modulation of platelet activity by bioactive phytochemicals. The aim of this study was to investigate the effects of bioactive-rich plant extracts and isolated bioactive metabolites on platelet function. Blood samples (n =15 subjects) were treated with extracts of bioactive-rich plants consumed as traditional foods in the Black Sea region, or with human metabolites of the bioactives quercetin and sulforaphane. Platelet function was assessed using the PFA-100. RESULTSNone of the extracts containing various flavonoids, glucosinolates and other bioactives, or isolated bioactive metabolites of quercetin or sulforaphane, caused significant changes in PFA-100 closure time (CT). In contrast, the positive controls (aspirin and Abciximab) consistently caused significant increases in CT for the platelet agonists epinephrine and ADP, respectively. CONCLUSIONThese data do not support the notion that these plant bioactives can improve human platelet function.
PB  - Wiley, Hoboken
T2  - Journal of the Science of Food & Agriculture
T1  - Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function
EP  - 3594
IS  - 14
SP  - 3588
VL  - 93
DO  - 10.1002/jsfa.6213
ER  - 
@article{
author = "Hollands, Wendy J. and Saha, Shikha and Hayran, Osman and Boyko, Nadiya and Glibetić, Marija and Konić-Ristić, Aleksandra and Jorjadze, Mariam and Kroon, Paul A.",
year = "2013",
abstract = "BACKGROUNDThe health benefits of fruit and vegetable-rich diets may be partly due to modulation of platelet activity by bioactive phytochemicals. The aim of this study was to investigate the effects of bioactive-rich plant extracts and isolated bioactive metabolites on platelet function. Blood samples (n =15 subjects) were treated with extracts of bioactive-rich plants consumed as traditional foods in the Black Sea region, or with human metabolites of the bioactives quercetin and sulforaphane. Platelet function was assessed using the PFA-100. RESULTSNone of the extracts containing various flavonoids, glucosinolates and other bioactives, or isolated bioactive metabolites of quercetin or sulforaphane, caused significant changes in PFA-100 closure time (CT). In contrast, the positive controls (aspirin and Abciximab) consistently caused significant increases in CT for the platelet agonists epinephrine and ADP, respectively. CONCLUSIONThese data do not support the notion that these plant bioactives can improve human platelet function.",
publisher = "Wiley, Hoboken",
journal = "Journal of the Science of Food & Agriculture",
title = "Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function",
pages = "3594-3588",
number = "14",
volume = "93",
doi = "10.1002/jsfa.6213"
}
Hollands, W. J., Saha, S., Hayran, O., Boyko, N., Glibetić, M., Konić-Ristić, A., Jorjadze, M.,& Kroon, P. A.. (2013). Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function. in Journal of the Science of Food & Agriculture
Wiley, Hoboken., 93(14), 3588-3594.
https://doi.org/10.1002/jsfa.6213
conv_3123
Hollands WJ, Saha S, Hayran O, Boyko N, Glibetić M, Konić-Ristić A, Jorjadze M, Kroon PA. Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function. in Journal of the Science of Food & Agriculture. 2013;93(14):3588-3594.
doi:10.1002/jsfa.6213
conv_3123 .
Hollands, Wendy J., Saha, Shikha, Hayran, Osman, Boyko, Nadiya, Glibetić, Marija, Konić-Ristić, Aleksandra, Jorjadze, Mariam, Kroon, Paul A., "Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function" in Journal of the Science of Food & Agriculture, 93, no. 14 (2013):3588-3594,
https://doi.org/10.1002/jsfa.6213 .,
conv_3123 .

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