Effect of iron intervention on growth during gestation, infancy, childhood, and adolescence: a systematic review with meta-analysis
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2013
Authors
Vučić, Vesna M.Berti, Cristiana
Vollhardt, Christiane
Fekete, Katalin
Cetin, Irene
Koletzko, Berthold
Gurinović, Mirjana
van't Veer, Pieter
Article (Published version)
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Show full item recordAbstract
To evaluate the effect of iron intervention on physical growth in fetuses, infants, children, and adolescents up to 18 years of age, a systematic review with meta-analysis of randomized controlled trials (RCTs) was conducted. Structured electronic searches were conducted to February 2010 using MEDLINE, Embase, and the Cochrane Library databases. RCTs that included iron-fortified foods, iron-fortified formula, or iron supplements and in which height, weight, mid-arm circumference (MAC), head circumference, birth weight, or length of gestation was evaluated were analyzed for inclusion. In total, 21 RCTs in infants, children, and adolescents and 7 studies in pregnant women met the inclusion criteria. The overall pooled result (random-effects model) showed no significant effects of iron intervention on any of the parameters measured. To accommodate wide heterogeneity, studies were stratified according to dose of iron, duration of intervention, age, and baseline iron status. However, only d...oses of 40-66mg of supplemental iron and intervention in children 6 years of age showed a slight but significant association with weight and MAC.
Keywords:
adolescents / children / EURRECA / infants / iron / physical growth / pregnancySource:
Nutrition Reviews, 2013, 71, 6, 386-401Publisher:
- Oxford Univ Press Inc, Cary
Funding / projects:
- Commission of the European Communities, specific RTD Programme "Quality of Life and Management of Living Resources," 6th Framework Programme [FP6-036196-2]
- Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-41030)
DOI: 10.1111/nure.12037
ISSN: 0029-6643
PubMed: 23731448
WoS: 000319878700006
Scopus: 2-s2.0-84878701873
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Vučić, Vesna M. AU - Berti, Cristiana AU - Vollhardt, Christiane AU - Fekete, Katalin AU - Cetin, Irene AU - Koletzko, Berthold AU - Gurinović, Mirjana AU - van't Veer, Pieter PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/471 AB - To evaluate the effect of iron intervention on physical growth in fetuses, infants, children, and adolescents up to 18 years of age, a systematic review with meta-analysis of randomized controlled trials (RCTs) was conducted. Structured electronic searches were conducted to February 2010 using MEDLINE, Embase, and the Cochrane Library databases. RCTs that included iron-fortified foods, iron-fortified formula, or iron supplements and in which height, weight, mid-arm circumference (MAC), head circumference, birth weight, or length of gestation was evaluated were analyzed for inclusion. In total, 21 RCTs in infants, children, and adolescents and 7 studies in pregnant women met the inclusion criteria. The overall pooled result (random-effects model) showed no significant effects of iron intervention on any of the parameters measured. To accommodate wide heterogeneity, studies were stratified according to dose of iron, duration of intervention, age, and baseline iron status. However, only doses of 40-66mg of supplemental iron and intervention in children 6 years of age showed a slight but significant association with weight and MAC. PB - Oxford Univ Press Inc, Cary T2 - Nutrition Reviews T1 - Effect of iron intervention on growth during gestation, infancy, childhood, and adolescence: a systematic review with meta-analysis EP - 401 IS - 6 SP - 386 VL - 71 DO - 10.1111/nure.12037 ER -
@article{ author = "Vučić, Vesna M. and Berti, Cristiana and Vollhardt, Christiane and Fekete, Katalin and Cetin, Irene and Koletzko, Berthold and Gurinović, Mirjana and van't Veer, Pieter", year = "2013", abstract = "To evaluate the effect of iron intervention on physical growth in fetuses, infants, children, and adolescents up to 18 years of age, a systematic review with meta-analysis of randomized controlled trials (RCTs) was conducted. Structured electronic searches were conducted to February 2010 using MEDLINE, Embase, and the Cochrane Library databases. RCTs that included iron-fortified foods, iron-fortified formula, or iron supplements and in which height, weight, mid-arm circumference (MAC), head circumference, birth weight, or length of gestation was evaluated were analyzed for inclusion. In total, 21 RCTs in infants, children, and adolescents and 7 studies in pregnant women met the inclusion criteria. The overall pooled result (random-effects model) showed no significant effects of iron intervention on any of the parameters measured. To accommodate wide heterogeneity, studies were stratified according to dose of iron, duration of intervention, age, and baseline iron status. However, only doses of 40-66mg of supplemental iron and intervention in children 6 years of age showed a slight but significant association with weight and MAC.", publisher = "Oxford Univ Press Inc, Cary", journal = "Nutrition Reviews", title = "Effect of iron intervention on growth during gestation, infancy, childhood, and adolescence: a systematic review with meta-analysis", pages = "401-386", number = "6", volume = "71", doi = "10.1111/nure.12037" }
Vučić, V. M., Berti, C., Vollhardt, C., Fekete, K., Cetin, I., Koletzko, B., Gurinović, M.,& van't Veer, P.. (2013). Effect of iron intervention on growth during gestation, infancy, childhood, and adolescence: a systematic review with meta-analysis. in Nutrition Reviews Oxford Univ Press Inc, Cary., 71(6), 386-401. https://doi.org/10.1111/nure.12037
Vučić VM, Berti C, Vollhardt C, Fekete K, Cetin I, Koletzko B, Gurinović M, van't Veer P. Effect of iron intervention on growth during gestation, infancy, childhood, and adolescence: a systematic review with meta-analysis. in Nutrition Reviews. 2013;71(6):386-401. doi:10.1111/nure.12037 .
Vučić, Vesna M., Berti, Cristiana, Vollhardt, Christiane, Fekete, Katalin, Cetin, Irene, Koletzko, Berthold, Gurinović, Mirjana, van't Veer, Pieter, "Effect of iron intervention on growth during gestation, infancy, childhood, and adolescence: a systematic review with meta-analysis" in Nutrition Reviews, 71, no. 6 (2013):386-401, https://doi.org/10.1111/nure.12037 . .