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dc.creatorKonić-Ristić, Aleksandra
dc.creatorSrdić-Rajić, Tatjana
dc.creatorKardum, Nevena Đ.
dc.creatorGlibetić, Marija
dc.date.accessioned2021-04-20T12:32:46Z
dc.date.available2021-04-20T12:32:46Z
dc.date.issued2013
dc.identifier.issn0352-5139
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/469
dc.description.abstractThe beneficial effects of black chokeberry fruits and juices in health promotion and prevention of chronic diseases shown in both epidemiological and dietary intervention studies are often connected with their antioxidant activity. The aim of this study was to investigate the total phenolics and anthocyanins content, chemical antioxidant activity (DPPH-assay), antioxidant protection in erythrocytes and anti-platelet activity in vitro of three different chokeberry products: commercial and fresh pure chokeberry juice and a crude lyophilized water-ethanol extract of chokeberry fruits, as part of their pre-clinical evaluation. The obtained results indicated differences in chemical composition and antioxidant activity of the investigated products. Cellular effects, including both in vitro anti-platelet and antioxidant effects, were not directly correlated with the chemical antioxidant activity and the results obtained in vitro for antiplatelet effects were only partially consistent with the results obtained in vivo, in a pilot intervention trial. In conclusion, chemical analyses and in vitro experiments on foods and their bioactive substances are a valuable pre-screening tool for the evaluation of their biological activity. However, extrapolation of the obtained results to the in vivo settings is often limited and influenced by the bioavailability and metabolism of native dietary compounds or interactions with differrent molecules within the human body.en
dc.publisherSrpsko hemijsko društvo, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41030/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectchokeberryen
dc.subjecterythrocytesen
dc.subjectplateletsen
dc.subjectDPPH assayen
dc.subjectflow cytometryen
dc.titleBiological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study designen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage443
dc.citation.issue3
dc.citation.other78(3): 429-443
dc.citation.rankM23
dc.citation.spage429
dc.citation.volume78
dc.identifier.doi10.2298/JSC121213020K
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/357/466.pdf
dc.identifier.scopus2-s2.0-84875858883
dc.identifier.wos000317160500011
dc.type.versionpublishedVersion


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Приказ основних података о документу