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Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design

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2013
466.pdf (700.0Kb)
Authors
Konić-Ristić, Aleksandra
Srdić-Rajić, Tatjana
Kardum, Nevena Đ.
Glibetić, Marija
Article (Published version)
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Abstract
The beneficial effects of black chokeberry fruits and juices in health promotion and prevention of chronic diseases shown in both epidemiological and dietary intervention studies are often connected with their antioxidant activity. The aim of this study was to investigate the total phenolics and anthocyanins content, chemical antioxidant activity (DPPH-assay), antioxidant protection in erythrocytes and anti-platelet activity in vitro of three different chokeberry products: commercial and fresh pure chokeberry juice and a crude lyophilized water-ethanol extract of chokeberry fruits, as part of their pre-clinical evaluation. The obtained results indicated differences in chemical composition and antioxidant activity of the investigated products. Cellular effects, including both in vitro anti-platelet and antioxidant effects, were not directly correlated with the chemical antioxidant activity and the results obtained in vitro for antiplatelet effects were only partially consistent with the... results obtained in vivo, in a pilot intervention trial. In conclusion, chemical analyses and in vitro experiments on foods and their bioactive substances are a valuable pre-screening tool for the evaluation of their biological activity. However, extrapolation of the obtained results to the in vivo settings is often limited and influenced by the bioavailability and metabolism of native dietary compounds or interactions with differrent molecules within the human body.

Keywords:
chokeberry / erythrocytes / platelets / DPPH assay / flow cytometry
Source:
Journal of the Serbian Chemical Society, 2013, 78, 3, 429-443
Publisher:
  • Srpsko hemijsko društvo, Beograd
Funding / projects:
  • Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-41030)

DOI: 10.2298/JSC121213020K

ISSN: 0352-5139

WoS: 000317160500011

Scopus: 2-s2.0-84875858883
[ Google Scholar ]
5
4
URI
http://rimi.imi.bg.ac.rs/handle/123456789/469
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Konić-Ristić, Aleksandra
AU  - Srdić-Rajić, Tatjana
AU  - Kardum, Nevena Đ.
AU  - Glibetić, Marija
PY  - 2013
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/469
AB  - The beneficial effects of black chokeberry fruits and juices in health promotion and prevention of chronic diseases shown in both epidemiological and dietary intervention studies are often connected with their antioxidant activity. The aim of this study was to investigate the total phenolics and anthocyanins content, chemical antioxidant activity (DPPH-assay), antioxidant protection in erythrocytes and anti-platelet activity in vitro of three different chokeberry products: commercial and fresh pure chokeberry juice and a crude lyophilized water-ethanol extract of chokeberry fruits, as part of their pre-clinical evaluation. The obtained results indicated differences in chemical composition and antioxidant activity of the investigated products. Cellular effects, including both in vitro anti-platelet and antioxidant effects, were not directly correlated with the chemical antioxidant activity and the results obtained in vitro for antiplatelet effects were only partially consistent with the results obtained in vivo, in a pilot intervention trial. In conclusion, chemical analyses and in vitro experiments on foods and their bioactive substances are a valuable pre-screening tool for the evaluation of their biological activity. However, extrapolation of the obtained results to the in vivo settings is often limited and influenced by the bioavailability and metabolism of native dietary compounds or interactions with differrent molecules within the human body.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design
EP  - 443
IS  - 3
SP  - 429
VL  - 78
DO  - 10.2298/JSC121213020K
ER  - 
@article{
author = "Konić-Ristić, Aleksandra and Srdić-Rajić, Tatjana and Kardum, Nevena Đ. and Glibetić, Marija",
year = "2013",
abstract = "The beneficial effects of black chokeberry fruits and juices in health promotion and prevention of chronic diseases shown in both epidemiological and dietary intervention studies are often connected with their antioxidant activity. The aim of this study was to investigate the total phenolics and anthocyanins content, chemical antioxidant activity (DPPH-assay), antioxidant protection in erythrocytes and anti-platelet activity in vitro of three different chokeberry products: commercial and fresh pure chokeberry juice and a crude lyophilized water-ethanol extract of chokeberry fruits, as part of their pre-clinical evaluation. The obtained results indicated differences in chemical composition and antioxidant activity of the investigated products. Cellular effects, including both in vitro anti-platelet and antioxidant effects, were not directly correlated with the chemical antioxidant activity and the results obtained in vitro for antiplatelet effects were only partially consistent with the results obtained in vivo, in a pilot intervention trial. In conclusion, chemical analyses and in vitro experiments on foods and their bioactive substances are a valuable pre-screening tool for the evaluation of their biological activity. However, extrapolation of the obtained results to the in vivo settings is often limited and influenced by the bioavailability and metabolism of native dietary compounds or interactions with differrent molecules within the human body.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design",
pages = "443-429",
number = "3",
volume = "78",
doi = "10.2298/JSC121213020K"
}
Konić-Ristić, A., Srdić-Rajić, T., Kardum, N. Đ.,& Glibetić, M.. (2013). Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 78(3), 429-443.
https://doi.org/10.2298/JSC121213020K
conv_2948
Konić-Ristić A, Srdić-Rajić T, Kardum NĐ, Glibetić M. Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design. in Journal of the Serbian Chemical Society. 2013;78(3):429-443.
doi:10.2298/JSC121213020K
conv_2948 .
Konić-Ristić, Aleksandra, Srdić-Rajić, Tatjana, Kardum, Nevena Đ., Glibetić, Marija, "Biological activity of Aronia melanocarpa antioxidants pre-screening in an intervention study design" in Journal of the Serbian Chemical Society, 78, no. 3 (2013):429-443,
https://doi.org/10.2298/JSC121213020K .,
conv_2948 .

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