History of exposure to dopaminergic medication does not affect motor cortex plasticity and excitability in Parkinson's disease
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2013
Authors
Kačar, AleksandraFilipović, Saša

Kresojević, Nikola D.

Milanović, Slađan

Ljubisavljević, Miloš

Kostić, Vladimir S.

Rothwell, John C.

Article (Published version)

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Objective: Little is known whether and how chronic exposure to dopaminergic treatment alters physiological mechanisms in Parkinson's disease (PD). Methods: Two clinically similar groups of PD patients, one consisting of drug-naive patients and another of patients already on chronic dopaminergic medication (when off medication), were compared to each other and to a control group. Plasticity and excitability of the hand primary motor cortex of the more affected side were evaluated using transcranial magnetic stimulation (TMS) techniques. Results: There was little difference between two patient groups, and both groups showed similar differences in comparison to controls: decreased facilitatory sensory-motor plasticity (as measured by paired associative stimulation [PAS] protocol), impaired short-interval intracortical inhibition (SICI), and diminished slope of input-output curves at higher TMS intensities. The exception was that 30 min after PAS, intracortical facilitation (ICF) was signi...ficantly reduced in drug-naive patients, whereas it changed much less in other two groups. Conclusions: Chronic exposure to dopaminergic drugs does not affect substantially the features of motor cortex excitability and plasticity in PD. There is little interaction between plasticity and excitability features of motor cortex in PD. Significance: Reduced response to facilitatory PAS protocol, reduced SICI, and reduced slope of the input-output curve at higher TMS pulse intensities, seem to be physiological markers for the presence of the pathological disease process in PD. Long term treatment does not seem to change the underlying physiology of the disease.
Keywords:
Parkinson's disease / Transcranial magnetic stimulation / Drug-naive / Plasticity / Excitability / Inhibition / Dopaminergic medicationSource:
Clinical Neurophysiology, 2013, 124, 4, 697-707Publisher:
- Elsevier Ireland Ltd, Clare
Funding / projects:
- Noninvasive modulation of cortical excitability and plasticity - Noninvasive neuromodulation of the CNS in the study of physiological mechanisms, diagnosis and treatment (RS-175012)
- Motor and non-motor symptoms and signs in parkinsonism: clinical, morphological and molecular-genetic correlates (RS-175090)
DOI: 10.1016/j.clinph.2012.09.016
ISSN: 1388-2457
PubMed: 23085389
WoS: 000316789200012
Scopus: 2-s2.0-84875065641
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Institut za medicinska istraživanjaTY - JOUR AU - Kačar, Aleksandra AU - Filipović, Saša AU - Kresojević, Nikola D. AU - Milanović, Slađan AU - Ljubisavljević, Miloš AU - Kostić, Vladimir S. AU - Rothwell, John C. PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/467 AB - Objective: Little is known whether and how chronic exposure to dopaminergic treatment alters physiological mechanisms in Parkinson's disease (PD). Methods: Two clinically similar groups of PD patients, one consisting of drug-naive patients and another of patients already on chronic dopaminergic medication (when off medication), were compared to each other and to a control group. Plasticity and excitability of the hand primary motor cortex of the more affected side were evaluated using transcranial magnetic stimulation (TMS) techniques. Results: There was little difference between two patient groups, and both groups showed similar differences in comparison to controls: decreased facilitatory sensory-motor plasticity (as measured by paired associative stimulation [PAS] protocol), impaired short-interval intracortical inhibition (SICI), and diminished slope of input-output curves at higher TMS intensities. The exception was that 30 min after PAS, intracortical facilitation (ICF) was significantly reduced in drug-naive patients, whereas it changed much less in other two groups. Conclusions: Chronic exposure to dopaminergic drugs does not affect substantially the features of motor cortex excitability and plasticity in PD. There is little interaction between plasticity and excitability features of motor cortex in PD. Significance: Reduced response to facilitatory PAS protocol, reduced SICI, and reduced slope of the input-output curve at higher TMS pulse intensities, seem to be physiological markers for the presence of the pathological disease process in PD. Long term treatment does not seem to change the underlying physiology of the disease. PB - Elsevier Ireland Ltd, Clare T2 - Clinical Neurophysiology T1 - History of exposure to dopaminergic medication does not affect motor cortex plasticity and excitability in Parkinson's disease EP - 707 IS - 4 SP - 697 VL - 124 DO - 10.1016/j.clinph.2012.09.016 ER -
@article{ author = "Kačar, Aleksandra and Filipović, Saša and Kresojević, Nikola D. and Milanović, Slađan and Ljubisavljević, Miloš and Kostić, Vladimir S. and Rothwell, John C.", year = "2013", abstract = "Objective: Little is known whether and how chronic exposure to dopaminergic treatment alters physiological mechanisms in Parkinson's disease (PD). Methods: Two clinically similar groups of PD patients, one consisting of drug-naive patients and another of patients already on chronic dopaminergic medication (when off medication), were compared to each other and to a control group. Plasticity and excitability of the hand primary motor cortex of the more affected side were evaluated using transcranial magnetic stimulation (TMS) techniques. Results: There was little difference between two patient groups, and both groups showed similar differences in comparison to controls: decreased facilitatory sensory-motor plasticity (as measured by paired associative stimulation [PAS] protocol), impaired short-interval intracortical inhibition (SICI), and diminished slope of input-output curves at higher TMS intensities. The exception was that 30 min after PAS, intracortical facilitation (ICF) was significantly reduced in drug-naive patients, whereas it changed much less in other two groups. Conclusions: Chronic exposure to dopaminergic drugs does not affect substantially the features of motor cortex excitability and plasticity in PD. There is little interaction between plasticity and excitability features of motor cortex in PD. Significance: Reduced response to facilitatory PAS protocol, reduced SICI, and reduced slope of the input-output curve at higher TMS pulse intensities, seem to be physiological markers for the presence of the pathological disease process in PD. Long term treatment does not seem to change the underlying physiology of the disease.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Clinical Neurophysiology", title = "History of exposure to dopaminergic medication does not affect motor cortex plasticity and excitability in Parkinson's disease", pages = "707-697", number = "4", volume = "124", doi = "10.1016/j.clinph.2012.09.016" }
Kačar, A., Filipović, S., Kresojević, N. D., Milanović, S., Ljubisavljević, M., Kostić, V. S.,& Rothwell, J. C.. (2013). History of exposure to dopaminergic medication does not affect motor cortex plasticity and excitability in Parkinson's disease. in Clinical Neurophysiology Elsevier Ireland Ltd, Clare., 124(4), 697-707. https://doi.org/10.1016/j.clinph.2012.09.016
Kačar A, Filipović S, Kresojević ND, Milanović S, Ljubisavljević M, Kostić VS, Rothwell JC. History of exposure to dopaminergic medication does not affect motor cortex plasticity and excitability in Parkinson's disease. in Clinical Neurophysiology. 2013;124(4):697-707. doi:10.1016/j.clinph.2012.09.016 .
Kačar, Aleksandra, Filipović, Saša, Kresojević, Nikola D., Milanović, Slađan, Ljubisavljević, Miloš, Kostić, Vladimir S., Rothwell, John C., "History of exposure to dopaminergic medication does not affect motor cortex plasticity and excitability in Parkinson's disease" in Clinical Neurophysiology, 124, no. 4 (2013):697-707, https://doi.org/10.1016/j.clinph.2012.09.016 . .