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dc.creatorLjujić, Biljana
dc.creatorMilovanović, Marija
dc.creatorVolarević, Vladislav
dc.creatorMurray, Bridgid
dc.creatorBugarski, Diana
dc.creatorPrzyborski, Stefan
dc.creatorArsenijević, Nebojša
dc.creatorLukić, Miodrag L.
dc.creatorStojković, Miodrag
dc.date.accessioned2021-04-20T12:32:03Z
dc.date.available2021-04-20T12:32:03Z
dc.date.issued2013
dc.identifier.issn2045-2322
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/458
dc.description.abstractHuman mesenchymal stem cells (hMSC) can home to tumor sites and promote tumor growth. The effects of hMSC on tumor growth are controversial and involvement of hMSC in tumor immunology has not been adequately addressed. Therefore, we investigated whether injection of hMSC affects tumor appearance, growth and metastasis, and anti-tumor immunity in an experimental animal model of metastatic breast cancer. Injection of hMSC in BALB/c mice bearing mammary carcinoma promoted tumor growth and metastasis, which was accompanied by lower cytotoxic activity of splenocytes, NK cells and CD8(+)T cells in vitro. Tumor-bearing mice that received hMSC had significantly lower percentages of CD3(+)NKp46(+) NKT-like, higher percentages of CD4(+)Foxp3(+) T cells, increased serum levels of Th2 and decreased serum levels of Th1 cytokines, and significantly higher number of CD4(+) cells expressing IL-10. These results demonstrate that immunosuppressive environment created by hMSC promoted breast tumor growth and metastasis in mice.en
dc.publisherNature Publishing Group, London
dc.relationFaculty of Medicine, University of Kragujevac, Serbia [JP 15/10]
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175103/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175069/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScientific Reports
dc.titleHuman mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in miceen
dc.typearticle
dc.rights.licenseBY
dc.citation.other3: -
dc.citation.rankaM21
dc.citation.volume3
dc.identifier.doi10.1038/srep02298
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/348/455.pdf
dc.identifier.pmid23892388
dc.identifier.scopus2-s2.0-84881188594
dc.identifier.wos000322359600002
dc.type.versionpublishedVersion


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