Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice

2013
Authors
Ljujić, BiljanaMilovanović, Marija

Volarević, Vladislav
Murray, Bridgid
Bugarski, Diana

Przyborski, Stefan
Arsenijević, Nebojša

Lukić, Miodrag L.

Stojković, Miodrag
Article (Published version)
Metadata
Show full item recordAbstract
Human mesenchymal stem cells (hMSC) can home to tumor sites and promote tumor growth. The effects of hMSC on tumor growth are controversial and involvement of hMSC in tumor immunology has not been adequately addressed. Therefore, we investigated whether injection of hMSC affects tumor appearance, growth and metastasis, and anti-tumor immunity in an experimental animal model of metastatic breast cancer. Injection of hMSC in BALB/c mice bearing mammary carcinoma promoted tumor growth and metastasis, which was accompanied by lower cytotoxic activity of splenocytes, NK cells and CD8(+)T cells in vitro. Tumor-bearing mice that received hMSC had significantly lower percentages of CD3(+)NKp46(+) NKT-like, higher percentages of CD4(+)Foxp3(+) T cells, increased serum levels of Th2 and decreased serum levels of Th1 cytokines, and significantly higher number of CD4(+) cells expressing IL-10. These results demonstrate that immunosuppressive environment created by hMSC promoted breast tumor growth... and metastasis in mice.
Source:
Scientific Reports, 2013, 3Publisher:
- Nature Publishing Group, London
Funding / projects:
- Faculty of Medicine, University of Kragujevac, Serbia [JP 15/10]
- Developing infrastructure for priority research fields (RS-175103)
- Molecular determinants of innate immunity in autoimmunity and tumorogenesis (RS-175069)
DOI: 10.1038/srep02298
ISSN: 2045-2322
PubMed: 23892388
WoS: 000322359600002
Scopus: 2-s2.0-84881188594
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Ljujić, Biljana AU - Milovanović, Marija AU - Volarević, Vladislav AU - Murray, Bridgid AU - Bugarski, Diana AU - Przyborski, Stefan AU - Arsenijević, Nebojša AU - Lukić, Miodrag L. AU - Stojković, Miodrag PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/458 AB - Human mesenchymal stem cells (hMSC) can home to tumor sites and promote tumor growth. The effects of hMSC on tumor growth are controversial and involvement of hMSC in tumor immunology has not been adequately addressed. Therefore, we investigated whether injection of hMSC affects tumor appearance, growth and metastasis, and anti-tumor immunity in an experimental animal model of metastatic breast cancer. Injection of hMSC in BALB/c mice bearing mammary carcinoma promoted tumor growth and metastasis, which was accompanied by lower cytotoxic activity of splenocytes, NK cells and CD8(+)T cells in vitro. Tumor-bearing mice that received hMSC had significantly lower percentages of CD3(+)NKp46(+) NKT-like, higher percentages of CD4(+)Foxp3(+) T cells, increased serum levels of Th2 and decreased serum levels of Th1 cytokines, and significantly higher number of CD4(+) cells expressing IL-10. These results demonstrate that immunosuppressive environment created by hMSC promoted breast tumor growth and metastasis in mice. PB - Nature Publishing Group, London T2 - Scientific Reports T1 - Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice VL - 3 DO - 10.1038/srep02298 UR - conv_3018 ER -
@article{ author = "Ljujić, Biljana and Milovanović, Marija and Volarević, Vladislav and Murray, Bridgid and Bugarski, Diana and Przyborski, Stefan and Arsenijević, Nebojša and Lukić, Miodrag L. and Stojković, Miodrag", year = "2013", abstract = "Human mesenchymal stem cells (hMSC) can home to tumor sites and promote tumor growth. The effects of hMSC on tumor growth are controversial and involvement of hMSC in tumor immunology has not been adequately addressed. Therefore, we investigated whether injection of hMSC affects tumor appearance, growth and metastasis, and anti-tumor immunity in an experimental animal model of metastatic breast cancer. Injection of hMSC in BALB/c mice bearing mammary carcinoma promoted tumor growth and metastasis, which was accompanied by lower cytotoxic activity of splenocytes, NK cells and CD8(+)T cells in vitro. Tumor-bearing mice that received hMSC had significantly lower percentages of CD3(+)NKp46(+) NKT-like, higher percentages of CD4(+)Foxp3(+) T cells, increased serum levels of Th2 and decreased serum levels of Th1 cytokines, and significantly higher number of CD4(+) cells expressing IL-10. These results demonstrate that immunosuppressive environment created by hMSC promoted breast tumor growth and metastasis in mice.", publisher = "Nature Publishing Group, London", journal = "Scientific Reports", title = "Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice", volume = "3", doi = "10.1038/srep02298", url = "conv_3018" }
Ljujić, B., Milovanović, M., Volarević, V., Murray, B., Bugarski, D., Przyborski, S., Arsenijević, N., Lukić, M. L.,& Stojković, M.. (2013). Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice. in Scientific Reports Nature Publishing Group, London., 3. https://doi.org/10.1038/srep02298 conv_3018
Ljujić B, Milovanović M, Volarević V, Murray B, Bugarski D, Przyborski S, Arsenijević N, Lukić ML, Stojković M. Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice. in Scientific Reports. 2013;3. doi:10.1038/srep02298 conv_3018 .
Ljujić, Biljana, Milovanović, Marija, Volarević, Vladislav, Murray, Bridgid, Bugarski, Diana, Przyborski, Stefan, Arsenijević, Nebojša, Lukić, Miodrag L., Stojković, Miodrag, "Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice" in Scientific Reports, 3 (2013), https://doi.org/10.1038/srep02298 ., conv_3018 .